Desloratadine syrup for children. Instruction, price, reviews

Syrups are the most comfortable form of medicine for treating children. One such remedy represented by Desloratadine - the mixture restores breathing, eliminates irritation of the throat mucosa, and also fights hoarseness and other problems that accompany ENT diseases. The liquid is easily divided into milligrams, so it is convenient to dose it for the smallest patients. An additional plus is the pleasant taste of the medicine.

Composition and form of release

The active ingredient of the syrup is desloratadine - 1 ml contains 0.5 mg of this component.

The list of excipients that make up the mixture is as follows:

• propylene glycol is a colorless liquid with a sweetish taste, characteristic aroma and hygroscopic properties;
• hexahydric alcohol sorbitol;
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• citric acid monohydrate;
• sodium salt of citric acid with a salty-sour taste;
• hypromellose;
• intense thermostable sweetener derived from sugar - sucralose;
• flavoring "tutti frutti";
• purified water.

Desloratadine comes in the form of a clear, slightly yellowish or completely colorless liquid. The volume of each bottle, made of dark glass, is 100 ml. In the kit, along with the instructions, the manufacturer packs a dosage spoon, and the packages themselves are made of cardboard.

Terms of sale, price

Desloratadine belongs to the OTC group due to its wide therapeutic range, the presence of a short elimination period and the degree of binding to plasma proteins less than 90%. You can buy it at any pharmacy, the average cost of a 60 ml bottle is 350-400 rubles.

The shelf life of a medicine in liquid form is no more than 24 months. It must be stored in its original packaging in a room where the temperature does not exceed 30 ^OWITH. And in a place where children cannot find syrup.

Action

Desloratadine syrup for children plays the role of a powerful selective beta-blocker of peripheral H1-histamine receptors - membrane proteins associated with the G-protein. When the dose is increased, the patient is not disturbed by the hypnotic effect, excitement or irritability. After swallowing the syrup, the active substance becomes a blocker of integral membrane proteins. This is explained by the fact that the drug practically does not seep through the barrier between the central nervous system and the circulatory system.

In the course of numerous clinical trials, scientists have found that antihistamine activity is not the only property of Desloratadine.

It has an anti-allergic effect that relieves symptoms of inflammation, and also contributes to:

• the production of pro-inflammatory cytokines necessary for the implementation of the protective functions of innate immunity;
• the release of pro-inflammatory chemokines produced by endothelial cells after their activation;
• elimination of bronchospasm arising from allergies and accompanied by cough.

Desloratadine prevents the development of immunopathological processes, expressed by the hypersensitivity of the immune system upon contact with irritants. In the case of chronic forms of allergy, the substance reduces their course. Due to the antipruritic and antiexudative effect, the permeability of the blood vessels, the development of edema of muscle tissues and narrowing of the lumen in the bronchi with contraction muscles.

The maximum concentration of the active components that make up the syrup in the plasma is observed half an hour after swallowing. Polyunsaturated fatty acids and fruit juices do not interfere with the distribution of desloratadine. The rate of binding to plasma proteins, on average, is 85-87%. The metabolism of the drug occurs in the liver, and a small part of the oral dose is excreted by the kidneys.

Indications and contraindications for use

Doctors recommend taking Desloratadine in the treatment of seasonal or perennial allergic rhinitis. This condition is usually accompanied by itchy palate, cough, nasal congestion, and nasal discharge. Other indications with a brief symptomatic picture are summarized in the table below.

Disease	Manifestation
Idiopathic chronic urticaria	The manifestation of itchy blisters, formed due to pinpoint edema of the papillary layer of the epidermis. The borders of the blister can be bright pink or purple, of different sizes, but with well-defined borders. Typical localization is absent, the primary elements, if untreated, expand, become the cause of neurotic excoriation, secondary infection.
Itchy dermatitis	Exhausting, very violent judgment, accompanied by eruptions. Redness of the skin, blood filling of the capillaries at the site of interaction with the allergen, swelling. Often, the rash is localized in the groin area, on the elbows and on the face. At the stage of exudation, cracks / peeling of the skin are possible, abundant separation of its particles.
Allergic conjunctivitis	Lachrymation, burning under the eyelids, itchy eyes, swelling and redness of the mucous membrane of the eye. With a severe form of pathology, the patient develops photophobia, an involuntary contraction of the circular muscle of the eye. With allergic conjunctivitis, a person constantly rubs his eyes, which leads to a layer of infection and the appearance of purulent secretions in the corners of the organs of vision.
Allergic reactions to bites of blood-sucking and stinging insects	Difficulty breathing, a feeling of suffocation, shortness of breath. Hives that quickly spread from the site of the bite throughout the body. A sharp rush of blood to the face with a subsequent decrease in the number of red blood cells.

Desloratadine syrup for children is strictly forbidden to give to babies under the age of one year. And also with increased individual sensitivity to any of the active ingredients, included in the medicine, and a hereditary disease associated with metabolic disorders amino acids. As for adults, it is advisable not to take Desloratadine during pregnancy and lactation, since the drug can pass into breast milk.

Clinical and pharmacological tests have shown that taking the syrup to patients with a severe stage of the syndrome of impaired renal function should be carried out under the strict supervision of the attending physician. The mixture contains sorbitol, so it is undesirable for patients who cannot tolerate fructose from the moment of birth.

Despite the fact that there is no adverse effect on driving after taking Desloratadine noted that it is important to focus on the fact that the individual reaction to active substances in all different. During treatment, which includes this syrup, it is advisable to refrain from work that requires maximum concentration and concentration. Until the reaction to the drug has been determined, it is not recommended to drive a car and operate complex technical devices.

Method of administration and dosage for children of different ages

To determine the optimal dosage regimen, it is better to consult a doctor, and not to self-medicate. Especially when it comes to babies who have not yet developed and strengthened the immune system. The safety of using the medicine for children under one year old has not been established, therefore, it is impossible to prescribe it for the treatment of idiopathic dermatosis and allergic rhinitis for babies of this age.

In all other cases, the dosage regimen is as follows:

• children from one to 5 years: 2 ml of substance (1 ml of desloratadine) 1 time per day, half an hour before meals;
• from 5 to 10 years: 3 ml of the mixture (1.75 mg of desloratadine) 1 time every 24 hours;
• 10 years and older: 5 ml of liquid substance 1 time per day.

Adult patients, whose body weight exceeds 30 kg, need to drink 10 ml of syrup once a day until the symptoms disappear completely. If necessary, the duration of treatment will be adjusted by the attending pediatrician.

Desloratadine can cause a variety of side effects. This syrup for children sometimes causes headaches, fatigue, dry mouth. The risk that the child, after taking the medication, will encounter a deviation from the "normal" line of behavior in the form of psychomotor hyperactivity, manifested in the form of panic and aggression, is 4%. Rare adverse reactions include elevated bilirubin, muscle pain, nausea, and dysmenorrhea.

The active substance lacks the ability to penetrate the central nervous system. If the recommended dose of 5 ml is not exceeded, then the rates of hypersomnia will not increase. In addition, laboratory studies have shown that even with a single dose of 6.5 ml, the syrup does not have any negative effect on psychomotor activity.

Exceeding the daily dose is fraught with clumsiness, instability and other anticholinergic effects. In case of an overdose, the central nervous system is already inhibited, hallucinations, involuntary muscle contractions, accompanied by sharp and aching pain, restless sleep occur. Often, blood pressure is also reduced by more than 20 units from the initial or normal value.

Since there are currently no narrowly targeted antidotes against Desloratadine, supportive and symptomatic treatment should be started immediately in case of an overdose. If the patient is conscious, you need to give him an agent that induces vomiting, after which - a few tablets of activated charcoal. And make sure that the patient drinks as much water as possible. If this effective attempt to induce the gag reflex is unsuccessful, professional medical attention should be sought. In such situations, doctors usually lavage the stomach with a gastric tube.

Some analogues

Desloratadine syrup for children, for one reason or another, not every parent dares to buy to treat their own child. The baby may be allergic to active substances, or the cost of the drug may become an obstacle. Therefore, today there are analogues of this syrup, which in their chemical structure practically do not differ from the original.

To choose a high-quality and effective generic, you need to check the packaging for spelling errors, damage, poorly typed text. If the batch number, expiration date and manufacturer's address on the primary and secondary packaging do not match, then it is better to pass by such an analogue. It is important to carefully study the composition to make sure that there are no components in it that may be allergic. The following are several popular generics of Desloratadine with a brief description of them.

Lordes

An anti-allergic, antipruritic and anti-exudative agent is intended for treating seasonal polynosis, the symptoms of which are lacrimation, itching of the palate, cough, congestion nose. Lordes is one of the most effective analogues of Desloratadine, quickly eliminates or reduces the symptomatic picture of chronic idiopathic urticaria. The generic contains the same components as the original drug. The only difference is the presence of cornstarch, talc and polyvinyl alcohol in lordes.

The dosage regimen and dosage regimen are identical to the original. It is worth taking this mixture with caution in patients with severe renal failure, during pregnancy and lactation. The drug is contraindicated in children under 10 years of age. The average cost of a medicine is 430 rubles.

Desal

The solution for oral administration is sold in dark glass vials with a volume of 60, 100, 150 and 300 ml. Included in each carton is a syringe dispenser for more convenient use.

Thanks to Desal, anti-inflammatory cytokines and chemokines are released in the body, adhesion molecules are released, and the development of tissue edema and smooth muscle spasm is prevented.

With such hereditary diseases as fructose intolerance, lack of sucrose in plasma, Desal is strictly prohibited. For all other points, the syrup meets its original. The price of one 60 ml bottle is 261 rubles.

Eslotin

Desloratadine syrup for children has many analogues, and Eslotin is one of the most popular. The mixture is colored orange, and also has an orange aroma and a sweet taste. The advantage of the product is good absorption from the digestive tract. The maximum accumulation in plasma after oral administration of Eslotin is achieved after 3 hours, and the drug is excreted from the body within 24 hours.

Children under 6 months old should not be given this syrup, since its effectiveness and safety of use in such small patients has not been proven. It is prescribed with caution to people with diabetes mellitus (at any time, the dosage of the hypoglycemic agent may need to be adjusted). The average cost of one bottle of Eslotin is 205 rubles.

Alergomax

This analogue of Desloratadine is already available in the form of capsules. It is an antihistamine pharmaceutical agent with anti-inflammatory and anti-allergic properties. Demonstrated to be effective in combating urticaria, allergic rhinitis with symptoms such as rash, sneezing, coughing, redness of the eyes, and so on.

It is forbidden to give Alergomax to children under 12 years of age, as well as to women who are carrying a child. To completely eliminate the symptomatic picture of allergies for a day, you need to drink one tablet a day, regardless of food intake. In rare cases, side effects occur in the form of insomnia, tachycardia, hepatitis, severe abdominal pain. On the part of the psyche and nervous system, there is an unreasonable fear, involuntary muscle contractions of different localization, dizziness. One pack of Alergomax tablets will cost 110 rubles.

Erius

An antihistamine that blocks peripheral H1-histamine receptors.

In case of an inflammatory disease of the nasal mucosa or urticaria, the dosage regimen of the drug, which is available in the form of tablets or medicine, is as follows:

• capsules: adults and children over 12 years old - 1 tablet per day (before or after meals), without chewing or drinking water;
• liquid substance: children from 6 months to a year - 2 ml per day, from one to 5 years - 3 ml, from 5 to 12 years - 5 ml (you can drink it with ordinary tap water).

Side effects with a haphazard increase in the daily dose are manifested in the form of rapid fatigue, fever, diarrhea. Insomnia, xerostomia, bradycardia are also not excluded. Side effects, which are quite rare, include myalgia, an increase in the level of bilirubin in the blood, anaphylactic shock.

The cost of one bottle of Erius syrup is 650 rubles. A package of tablets costs 670 rubles.

Ezlor

This anti-allergic agent in capsules must be swallowed without chewing, and it is advisable to drink it with water for better absorption in the digestive tract. Adults and children from 10 years old - 1 capsule once a day, preferably in the morning. Contraindications, the list of side effects is no different from the original drug and its generics listed earlier.

You can buy a pack of Ezlor in Moscow drugstore chains, on average, for 209 rubles. There are 10 capsules in a pack, but there are also polymer cans, in which 40, 50 and even 100 tablets at once. This will already cost more.

Desloratadine is an effective remedy for the symptoms of allergic rhinitis and hives. Syrup for children can be replaced with no less effective generic drugs, which today can be found in any pharmacy.

Video about the drug Desloratadine

Instructions for the use of Desloratadine: