Treatment of non-insulin dependent forms of diabetes begin with lifestyle changes. If this does not produce the desired results, the doctor prescribes hypoglycemic agents. Endocrinologist determines in an individual case, which is better: Gliformin or Metformin. The drug is selected after laboratory diagnostics.
formulations of drugs
Medicinal properties of the active ingredients of medicines determined because the comparison and Metformin Gliformina starts with their compositions and dosage forms.
Metformin released in the form of tablets, the active ingredient metformin hydrochloride. One tablet of 0.5 grams, 0.85 and 1 g of active substance. Ten to twenty tablets a contour packs in a cardboard bundle by 3,4 and 6 of cellular packages.
Gliformin contains similar active substance - metformin hydrochloride. Each tablet Gliformina 0.25 g, 0.5 g, 0.75, and 1 g of active substance. Both drugs are sustained-release forms.
Auxiliary components Metformin: magnesium stearate, povidone, macrogol, hypromellose. In Gliformine shaping composition contains the glycerol, starch, macrogol, hypromellose, silicon dioxide.
In composition Gliformin is an analogue of Metformin. But Gliformina is a form of release with a reduced dose of the active substance that will adhere more convenient dosing regimen in the appointment of the minimum therapeutic dose.
medicinal properties
Metformin - a drug with a hypoglycemic action.
It has these effects:
- It makes receptors more sensitive to insulin;
- enhances cell recycling sugars;
- reduces the production of sugar in the liver;
- It slows down the absorption of sugars in the small intestine;
- It stimulates the synthesis of glycogen;
- increases the transport capacity of glucose transporters in cell membranes.
Unlike sulfonylureas, metformin does not increase insulin synthesis, because no effect on blood sugar levels in healthy people.
The drug is well affects the metabolic processes in adipose tissue. It reduces the concentration of bad cholesterol and its vectors in the blood. body weight in the treatment of weight loss is constant or gradually. Metformin is effective in the treatment and in the prevention of type II diabetes when lifestyle changes do not produce the desired results in the control of glucose levels.
Gliformin exerts similar effects due to the content of the same active ingredient. It affects the formation of fatty acids and lipid oxidation, inhibits glucose synthesis. Gliformin reduces the level of harmful cholesterol in the blood. Weighted exerts a similar effect. The difference between the metformin and Gliforminom of curative properties imperceptible.
Indications for
The manufacturer cites the following indications for the reception of Metformin:
- Diabetes Type II diabetes;
- monotherapy or combination with other medications when diet and activity level correction not allowed to control the level of sugar;
- children from ten years - the addition of insulin or diabetes monotherapy;
- prevention in prediabeticheskom condition;
- prevention in diabetes risk factors.
Gliformin has similar indications. Take Gliformin recommended as if diagnosed with diabetes and for the prevention of these conditions.
Contraindications
Take Metformin is prohibited under these conditions:
- intolerance of the composition components;
- coma or prekomatosnoe state ketoacidosis;
- severe renal disease;
- state, threatening renal dysfunction;
- disease that can cause tissue hypoxia: acute dysfunction or myocardial infarction, asphyxia, chronic heart dysfunction;
- state, under which shows the amplified reception insulin;
- serious diseases of the hepatobiliary system;
- abuse of alcohol, lactic acidosis;
- pregnancy;
- calorie diet with up to thousands of calories a day.
You can not take metformin or Gliformin two days before and after the instrumental diagnostics with contrast media. In pregnancy, a drug substitute for insulin to keep blood sugar levels close to normal.
Caution should be observed in the treatment of patients older than 61 and with heavy physical labor, during lactation, as a teenager, and renal diseases.
joint reception
Take Metformin along with Gliforminom not necessary. Both drugs are synthesized on the basis of a single active ingredient, so do not complement each other in their effects.
If you take Gliformin simultaneously with metformin increases the risk of overdose of metformin hydrochloride.
It is manifested by symptoms:
- severe weakness;
- difficulty breathing;
- drowsiness;
- vomiting, nausea;
- pain in the stomach;
- diarrhea;
- low body temperature and blood pressure;
- heart rhythm disturbances.
In severe cases, develop muscle cramps, loss of consciousness. Treatment is carried out only in a hospital environment, efficient cleaning of blood on artificial kidneys and symptomatic treatment. Jointly take Gliformin with metformin is not recommended to prevent the development of an overdose.
The difference between drugs
Compare products difficult, as they are interchangeable in the treatment of hyperglycemic conditions. Special difference in their efficiency and a method of receiving there. The choice of medication depends on the personal experience of the endocrinologist in the treatment of diabetes mellitus, or precede it states.
Metformin is a complete analog Gliformina, but your doctor may recommend other similar products:
- Glucophage;
- Formetin;
- Siofor.
Analogs with a combined composition: Yanumet, Glimekomb, Glyukovans, Galvus Met. Analog should choose only a specialist and the results of tests to find a suitable dosage and application scheme.
sources:
Vidal: https://www.vidal.ru/drugs/metformin-5
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = ac45cb5c-4394-42ca-8479-a60a7a67e0b0 & t =
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