For correction of blood glucose levels in diabetes or preceding states are assigned different groups of hypoglycemic drugs. Endocrinologist picks it best: Gliclazide and Metformin in each case individually. Comparison of products carried by them to the active compounds, since they identify all therapeutic properties.
The compositions of drugs
Metformin is sold in tablet form at a concentration of 0.5 g, and 0.85 g of active ingredient 1 - metformin hydrochloride. The blister is released from 10 to 20 tablets, in a cardboard bundle - 3,4 and 6 outline packages. Auxiliary composition: magnesium stearate, macrogol, hypromellose, povidone.
If we compare metformin and gliclazide, the last active substance - gliclazide containing 30, 60 and 80 mg in each tablet. Tablets of 5, 7 and 10 in the blister units, in a stack of 10 to 300 tablets. The mold composition: hypromellose, mannitol, magnesium stearate, silicon dioxide, cellulose, and vegetable oil.
The compositions of drugs are different because their mechanisms of action are also different.
Medicinal properties of Metformin
Metformin has a hypoglycemic effect due to such effects in the body:
- receptors enhances insulin sensitivity;
- improves cellular glucose processing;
- slows the absorption of glucose in the gut;
- reduces glucose production in the liver;
- It stimulates the production of glycogen;
- increases the transport capacity of glucose transporters in cell membranes.
It does not increase insulin synthesis and has no influence on the content of sugars in the blood of healthy people. It has a positive effect on fat metabolism. Metformin reduces total cholesterol and its vectors in the bloodstream. Weight remains stable or gradually decreases.
To show drug
Metformin is prescribed for the treatment of such conditions:
- Diabetes Type II diabetes;
- monotherapy or in combination with other agents, when the level of activity and diet adjustment not led to an improvement in well-being;
- Children from 10 years - in the treatment of diabetes within monotherapy or combination with insulin;
- prevention prediabeticheskih states.
Metformin is appointed and diabetes risk factors. It is effective both in therapy and in the prevention of diabetes.
properties gliclazide
Gliclazide - is an analogue of the French drug Diabeton made in Russia. Pharmacological properties gliclazide somewhat different. This is representative of the sulfonylurea derivatives. It acts by stimulating insulin secretion in the pancreas. It makes the peripheral tissues more sensitive to insulin. Reduces the period of time between meals prior to insulin.
On the cardiovascular system also acts favorably. Reduces the risk of blood clots, normalizes the quality indicators of the vascular walls and their permeability, lowers cholesterol and free radicals.
Gliclazide is able to reduce sensitivity to adrenalin vessel and improve the blood circulation in capillaries. In diabetic kidney disease marked decrease in the level of protein in the urine Propafenone gliclazide.
Indications for
Gliclazide is prescribed for hyperglycemia. It is effective in cases where the assigned diet and exercise did not improve the condition of the patient.
Gliclazide is also effective to reduce the risk of diabetic complications such as nephropathy, stroke, retinopathy or myocardial infarction. Appointed by and within the framework of prevention.
The difference in the medications
The difference between Gliclazide and Metformin drugs in the ways of their actions, although the result is the same - the hypoglycemic effect. Gliclazide acts by stimulation of insulin secretion, so affecting the concentration of glucose in the bloodstream.
Metformin has a direct impact on the concentration of glucose in the blood, because it reduces its synthesis in the liver and accelerates at the cellular level processing. The rest of the products are similar, have the same indications for use.
joint application
Together Gliclazide and Metformin is successfully used in endocrinology in the composition of the drug Glimekomb. It contains 0.5 grams metformin and 0.04 mg of gliclazide.
The drug is taken at a dose of 1 to 3 tablets a day, at morning and dividing reception. Maximum dosage per day - 5 tablets. Individual dose selects the physician observing the body's response to treatment.
Metformin along with gliclazide and take on such a scheme:
- Gliclazide: 80 mg twice a day before meals, not more than 320 mg per day;
- Metformin: 0.5 or 0.85 g three times a day after meals, no more than 3 grams per day;
- two weeks Metformin dose adjusted to 1.5 g per day in three divided doses.
Taking drugs should be constantly, every day. Swap practices and take Gliclazide is not recommended after metformin. Gliclazide should trigger enhanced release of insulin during meals, not after digestion, to avoid sharply hyperglycemia. Dosing regime chooses only endocrinologist.
sources:
Vidal: https://www.vidal.ru/drugs/metformin-5
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = ac45cb5c-4394-42ca-8479-a60a7a67e0b0 & t =
Found a bug? Select it and press Ctrl + Enter
