Metformin: what helps and what is prescribed

The composition and form of the drug

The medicament is released in the form of tablets with active ingredient metformin hydrochloride. One tablet of 0.5 grams, 0.85 and 1 g of active substance. Ten to twenty tablets a blister in a cardboard bundle by 3,4 and 6 of cellular packages.

Additional components in the metformin: magnesium stearate, povidone, macrogol, hypromellose. The drug has few indications for use associated with insulin deficiency.

Type 2 diabetes

Metformin helps with diabetes as a part monotherapy and in combination with other drugs of similar action. The dosage ranges from 0.5 to 0.85 g in two or three doses per day. Tablets are taken after a meal or during the reception.

Drugs can help with hyperglycemia due to such effects:

• increase sensitivity to insulin receptors;
• activation of the cellular processing of sugars;
• reduction in liver sugar production;
• increasing the transport capacity of membrane transporters of sugar in the cells;
• stimulation of glycogen synthesis;
• delayed absorption of sugars in the small intestine.

Metformin does not increase the insulin level because operates softer than the drug with a sulfonylurea. But to prevent the side effects of the daily dose is still divided into several stages.

The maximum dosage - 3 grams per day. If such dosage appointed endocrinologist, convenient to take with metformin active substance content of 1 g per tablet. When switching from other hypoglycemic drugs first stop taking the previous drug, and then immediately start taking Metformin.

Metformin is effective in cases where the physical activity and nutrition correction does not help normalize glycemia. During treatment it is necessary to continue the diet even if she herself did not show the desired results.

Combination with insulin

Sometimes, to achieve a stable level of glucose in the blood metformin alone fails. Then prescribed combination of insulin and metformin in patients with a second type of diabetes. Dosage - 0.85 g, and the concentration of insulin is selected immediately after the blood sugar level measurement.

Prediabeticheskie state

If the fasting blood glucose level above 5-5.5 mmol / ml but not greater than 7, a state is called prediabeticheskim. In this case, to prevent the development of diabetes hypoglycemic drugs prescribed in the maintenance dose.

Metformin at prediabeticheskom state need twice daily at a dose of 1-1.7 grams per day. This is 0,5-0,85 g per dose, depending on the level of glucose in the bloodstream indicators.

In pediatrics

At the age of ten years, the treatment of diabetes, metformin is carried out in combination with insulin, with or without it, depending on the child's blood glucose. The dosage is similar as for adults.

After 15 days, held a second level of fasting blood glucose control to adjust the dosage. The maximum dose of Metformin in pediatrics - 2 grams 2-3 times daily. From 10 to 12 years, treatment with metformin requires caution and careful monitoring by an endocrinologist and a pediatrician.

Weight Loss

Metformin Glucophage or its equivalent - is popular drugs among people wanting to lose weight. Before taking Metformin with obesity, it is necessary to consult an endocrinologist and nutritionist.

Effects of the drug, helps to lose weight, are secondary. Maintaining stable body weight or gradual weight loss achieved influence on the fat balance. Metformin is able to affect the concentration of bad cholesterol in the blood and its carriers - lipoproteins.

Usually, a maintenance dosage - 0.5 g twice a day after meals. Metformin on insulin levels is not affected, because more secure in order to lose weight. But it is not advisable to take it without the control of the endocrinologist - a doctor should monitor blood sugar on an empty stomach.

sources:

Vidal: https://www.vidal.ru/drugs/metformin-5
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = ac45cb5c-4394-42ca-8479-a60a7a67e0b0 & t =

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