Analgesic drug Diclofenac belongs to the group of non-steroidal agents. its simultaneous application with many groups of medications contraindicated. You need to know how long the output Diclofenac from the body to continue the treatment by other means.
The assimilation of the drug
The active ingredient diclofenac drug is quickly absorbed into the blood and use it to be delivered to sites of inflammation. Ingestion affects the absorption rate, but the concentration of the substance is not reduced.
at orally (Pills) of medication for a long time he is released so the maximum level of drug in the blood is observed within 2 hours after consumption.
Injection solution means (injections) has a saturated structure so the exposure time is greatly reduced, and the limiting saturation appears after 15-20 minutes. The concentration of the substance is increased as much as the dosage increases. Also it depends on the application method. For example, rectal administration increases the accumulation of up to half an hour.
Scheme removal means from the body
In use, the drug substance is absorbed into the bloodstream almost no residue: 99% coupled with proteins. Diclofenac excreted through the urinary tract in a nontoxic constant active component partially - in bile and feces in the form of metabolites. After the first dose, about 70% means weight excreted by the kidneys within 24 hours. The remaining amount synthesized in the liver, then - beyond the urine. It takes about 2 hours and the plasma half-life of up to 6 hours - from the synovial fluid.
The use of diclofenac is not addictive. Subject to the receiving interval preparation of the Diclofenac instructions for use, The substance does not accumulate in the body. Long-term use has desensitizing effect - reduced sensitivity to foreign proteins that cause allergic reactions.
Diclofenac compatibility with alcohol
After consuming alcohol intake Diclofenac is prohibited. Alcohol increases the intensity of the drug and cause negative consequences. Since the medication is available in different types, which differ in concentration, and the response to alcohol in the process of applying different:
- injection may cause headache, nausea, edema and disruption of the kidney until renal failure. After a shot of alcohol put Diclofenac can be no earlier than 48 hoursThat would display all substances decay.
- tablets cause acute diarrhea, vomiting, swelling of the extremities, face. The liver also can not fully operate and unable to quickly bring Diclofenac. Its components begin to destroy its cells.
- intoxicated can not use candles. This may cause internal bleeding, increased blood pressure. Incompatibility leads to a locked state, and malfunction of the nervous system.
- cream and gel under the influence of alcohol give rise to allergic reactions on the skin irritation.
sources:
Vidal: https://www.vidal.ru/drugs/diclofenak__11520
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = 5d8a978b-56fd-4465-bfa0-907ab6103f33 & t =
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