Metformin is usually used in the treatment of diabetic patients, but this drug, there is another area of use. According to recent studies, metformin may be used against cancer. The drug thereby reducing the probability of cancer pathology, and also reduces the growth rate of tumor cells if there is already a neoplasm in a patient. It is a proven scientific fact.
The properties of the drug
Metformin is manufactured as a tablet form (500 mg, 850 mg, 1000 mg). Curative component is metformin hydrochloride. The drug may reduce the rate of gluconeogenesis in the liver tissue decrease the amount of glucose molecules.
Means reduces the amount of fatty acid oxidation inhibits fat molecules. Glucose molecules by the action of the drug is better utilized. The drug does not alter the amount of blood insulin. Scientists say that the tool helps fight obesity and early old age. The drug prevents cell aging brain and heart tissue.
The drug is approved for purpose in children from the age of 10. It can be used as a standalone tool or in conjunction with other drugs that reduce the sugar in the bloodstream. the drug is often used in conjunction with insulin.
Limitations to the use of tools:
- metabolic acidosis;
- coma and predkomatoznoe state in patients with diabetes;
- significant renal dysfunction, liver;
- a severe infection;
- hypoxic conditions (heart disease, changes in respiratory function);
- intravenous drugs, having in its composition iodine for X-ray and computer tomography;
- poisoning of spirituous drinks and drugs;
- Patients under 10 years of age;
- are allergic to components of the tool.
Means used carefully in patients 10-12 years of age, patients older than 60 years of age. Not shown the drug to pregnant patients and nursing mothers. Before you take the means necessary to see a doctor in order to avoid the limitations and possible undesirable effects.
The use of drugs in cancer patients
Metformin treatment of cancer are increasingly carried out by oncologists. The drug is allowed to be used in patients with breast cancer. In men, a medicine indicated for prostate cancer.
Metformin is effective against pancreatic cancer, medullary thymic cancer. There is evidence that the drug helps in colorectal cancer, which often develops in patients with type 2 diabetes.
Pancreas cancer
Over the past few years it has been carried out a sufficient number of studies that have confirmed the anti-tumor effects of metformin. This effect is revealed by accident. Patients with type 2 diabetes were given long courses Metformin as a hypoglycemic drug. The therapy has been observed that in the test group taking metformin, reduced the likelihood of developing cancer pathology of various localizations. In the control group, which received no hypoglycemic drug, cancer occurrence rate was higher.
Further antitumor effect began to study in more detail. It was found that the drug metformin reduces the risk of cancer, if it is combined with insulin or use as a standalone drug. The action of the drug can be explained by the fact that metformin activates the AMP-kinase enzymes. In this process involved LKB-1 protein molecule. It reduces the growth of tumor and cellular structures.
If the patient has a tumor, metformin is capable of reducing the risk of early mortality. Studies have shown that patients with type 2 diabetes with colorectal cancer, in the preparation of Metformin lived longer. Life expectancy has increased almost 2 years.
conclusion
Metformin does the evidence base about the availability of anti-tumor effect. The drug can be used for the prevention of cancer pathology. In cancer patients, the drug prolongs life. Research will continue to bring out more new data on the effectiveness of the drug in tumor processes.
sources:
Vidal: https://www.vidal.ru/drugs/metformin-5
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = ac45cb5c-4394-42ca-8479-a60a7a67e0b0 & t =
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