On the substance metformin physicians respond in two ways. On the one hand, with its drugs containing vital in diabetes, with another - the drug has many side effects. Benefits and harms the body of Metformin does not stop studied. Today opened a lot of additional properties of the medication with a substance metformin.
Beneficial effect in diabetes
Substance metformin benefits people with an increased concentration of glucose in blood, a reduction reaction to the hormone receptor-dependent insulin tissues. Metformin affects the liver: without harm to the body activates the synthesis of protein. This enzyme is involved in the processing of glucose, fat metabolism and inhibits gluconeogenesis.
As a result of the action of Metformin:
- reduced concentration of blood sugar;
- not disturbed insulin secretion;
- no energy starvation cells appears;
- slowing glucose absorption through the intestinal membrane;
- stop weight gain on a background of hyperglycemia;
- increases glucose uptake by muscles;
- activated production of glycogen;
- increases glucose uptake during transport and glycogen formation;
- It lowers the concentration of cholesterol and LDL lipoprotein class;
- decreases triglycerides;
- It increases the sensitivity of target cells to the pancreatic hormone insulin;
- an overwhelming sense of hunger;
- escalating prediabetes occurs in diabetes type 1-2.
It remains in doubt the benefits and harms of metformin in the treatment of diabetes in pregnant women, lactating women, elderly and young people. The substance penetrates through the placenta and breast milk. Since no controlled clinical trials of patients of these groups, they prescribe medication in case of exceeding the anticipated benefits of the potential harm to health.
On a note!According to German physicians in the treatment of gestational diabetes from Metformin appears predisposed the child to a breach of tolerance to insulin.
Beneficial effects in obesity
Not unequivocal benefits of metformin for the purpose of correction of weight. The instructions clearly stated that the weight can remain stable under non-insulin dependent diabetes. Healthy person to lose weight, you need to simultaneously perform enhanced aerobic exercise, diet and observe malouglevodnuyu a month to drink the drug.
Not proved absolute benefit medication for weight loss, but the side effects often harmful to the digestive tract. One out of 10 people starts diarrhea, bloating, stomach pain, vomiting.
Other efficiencies
Dermatologists consider it appropriate to metformin use in acne and other skin diseases. The benefits of the tablets will come when disease develops on the background of hyperglycemia. Artificial lowering of glucose in the blood and lipoptroteinov promotes healing of superficial lesions and inflammation of epidermal tissue.
Other benefits to the body from the action of metformin:
- slowing down the aging brain cells;
- inhibits the development of osteoporosis;
- promotes neuronal regeneration;
- improves the structure of the nerve fibers;
- prevents an increase of atherosclerotic plaques;
- warns obesity;
- It contributes to the normalization of ovarian function, erection.
Recent studies have shown that metformin substance has an indirect impact on the renewal of life. Metformin prevents COPD, all types of cancer, is beneficial for the functioning of the cardiovascular, endocrine, nervous and digestive systems. The drug is effective in the treatment of polycystic ovary syndrome, diabetes complications, reversible infertility.
Harmful influence on the organism
First, metformin is used in the treatment of influenza. Now the drug is contraindicated in infectious diseases. Studies have shown that metformin is not compatible with ethanol, and a number of NSAIDs, antibiotics, antiviral and antimicrobial agents interferes with the action of substance. Damage from improper combination is applied kidneys and liver. In organs may develop inflammation of the membranes is not sufficient.
Other damage Metformin:
- dermatitis;
- itching;
- rash;
- taste disturbance;
- aversion to food;
- anemia due to decreased absorption of vitamins of group B;
- fall in glucose below normal;
- hypoglycemic shock, coma.
The drug is poorly tolerated. Most often, the damage gets the gastrointestinal tract. A person because of Metformin is vomiting, diarrhea, dyspepsia. These side effects can pass after dose reduction or after a couple of weeks of tablets.
Dangerous drugs damage due to the effects on fat metabolism. A person with long-term metformin may develop lactic acidosis. The pathology is accompanied by muscle pain, cardiac arrhythmias and respiratory functions, weakness, reducing the pressure. This disease worsens the health and life-threatening.
conclusion
Predominant benefit to the organism if Metformin is taken with respect doctor's recommendations and instructions stated. Damage has grown significantly in the case of overdose substance metformin, used drugs in the presence of contraindications. The drug is dangerous to combine with other drugs without your doctor's knowledge. If the wrong combination of substances possible liver cirrhosis, renal failure, hypoglycemic crisis.
sources:
Vidal: https://www.vidal.ru/drugs/metformin-5
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = ac45cb5c-4394-42ca-8479-a60a7a67e0b0 & t =
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