From the testimony drugs and properties of therapeutic agents depends when taking Metformin: before meals or after meals. The preparation of conventional release tablets and sustained release with 3 types of shells or uncoated. These differences are also often important to determine the time of receiving means correctly.
action Medicine
After consumption hypoglycemic drug Metformin it metformin active substance is determined with a maximum concentration after 120-150 minutes in plasma. Receiving fasting allows almost 70% of the dose to reach the tissues of the internal organs, brain and muscles. If at the same time means a drink with a meal, the food inhibits metformine adsorption for half an hour. This helps substance delay the absorption of carbohydrates from the diet.
Common side effects of Metformin tablets:
- pain in the stomach area location;
- vomiting;
- bloating;
- flatulence;
- diarrhea;
- nausea;
- loss of appetite;
- metallic aftertaste in the mouth.
Described symptoms of dyspepsia and indigestion appear in the first few weeks of treatment. To reduce the likelihood of their occurrence, it is better to take Metformin along with the consumption of food. This recommendation applies to all drug analogues comprising metformin.
Tablets are film coated
Film coating achieves stomach tablet and then begins the release of the active ingredient. Metformin with this type of coverage to use correctly one time with a meal or in the first 5 minutes after breakfast, lunch and / or dinner. Tablets desirable to drink the drinking water abundantly temperatures below 40ยบ C.
The tablets in the enteric coating
The enteric coating begins to melt in the duodenum 12 and allows the agent to be released in the gastrointestinal average. This reduces the likelihood of acute gastritis. Metformin tablets with this type of shell makes the Serbian company Hemmofarm. In preparation instructions stated that take the prescribed dose at a time with a meal or immediately after a meal. Washed down with a glass of water medication.
Uncoated Tablets
The lack of coverage on the pill has three advantages: metformin immediately begins to be released in the digestive system does not fall ballast substances, reducing the likelihood of allergies. Without a shell can not take Metformin before meals on an empty stomach: the digestive tract immediately react negatively. The instructions tablets without film coating recommended drink preparation together with food either in the first 5 minutes after the completion of its reception. The medicine is drunk 125-200 ml of water.
prolonged tablets
Sustained action preparations allows the therapeutic agent to be released gradually. Metformin Tablets release coated or uncoated. As the dissolution of the barrier layers in the blood flow enters the required single dose. This makes it possible hypoglycemic agent to take 1 time / day.
Metformin extended release tablets have:
- Long;
- Long Canon;
- MW;
- MB-Teva.
Hypoglycemic agents from the list take in the evening 1 p. / Day. Tablet at the same time drink with dinner or after its completion. If this pattern of use does not help to control the level of glucose, the doctor will recommend a daily dose divided into 2 times and take a breakfast meal, dinner.
Combination products
By a combined hypoglycemic agents include tablets Galvus Met, Bagomet Plus, Glimekomb, Amaryl M, Avandamet, Yanumet. These formulations comprise two antidiabetic agents: metformin (at a higher dose) and vildagliptin, glibenclamide, gliclazide, glimepiride, rosiglitazone or sitagliptin.
At the same time as the meal take funds from a combination of materials plus metformin:
- vildagliptin;
- glibenclamide;
- gliclazide;
- glimepiride;
- rosiglitazone;
- sitagliptin.
Additional hypoglycemic agents in the tablets administered in a small dose and usually do not cause indigestion. The instructions of the combined preparations containing metformin indicate that the drug taking at the same time with the consumption of food. This reduces the probability of occurrence of dyspepsia because of the action of metformin.
Acceptance of the drug for weight loss
On the Internet, information is often found that taken with metformin tablets on an empty stomach accelerates the process of losing weight. This is dangerous: receiving hypoglycemic drugs on an empty stomach can cause a sharp decrease in the concentration of glucose. In a healthy person possible sudden health deterioration and severe dyspepsia and diabetic patients fasted facing crisis.
The instructions medication of any manufacturer stated that they drink metformin only after a meal (within the first 5-10 minutes at the end of the meal) or at the same time with the consumption of food.
the reader
Metformin tablets of any variety is prohibited crush or chew during the reception. This contributes to a sharp substance entering the blood and may cause hypoglycemic crisis. Do not exceed the daily dosage of the drug in 3000 mg. A one-time consumption of the means of food significantly reduces the likelihood of side effects from metformin. Upon receiving the medication or eat again desirable to use a liquid for at least one hour.
sources:
Vidal: https://www.vidal.ru/drugs/metformin-5
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = ac45cb5c-4394-42ca-8479-a60a7a67e0b0 & t =
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