Obesity leads to many diseases, especially the suffering cardio-vascular system. Since obesity is directly related type 2 diabetes. Reducing body weight improves health. In addition to changes in diet and living habits, as you can use pharmacotherapy for obesity pill to lose weight - Metformin.
Characteristics and properties of the drug
Metformin belongs to the pharmaco-therapeutic category hypoglycemic agents for internal use biguanide group.
The main active ingredient - metformin. The drug comes in tablet form.
properties
The action of the drug due to the properties of the active ingredient - metformin:
- inhibition of gluconeogenesis;
- fat oxidation;
- formation of free fatty acids.
Metformin improves insulin sensitivity receptors and processing of glucose by cells. The component does not alter the quantitative number of insulin in the blood, and reduces the proportion of insulin (both bound and free), thereby changing its pharmacodynamics.
According to the instructions to the drug Metformin has an effect on body weight - stabilizes or decreases moderately. Therefore, obesity is allowed to take metformin.
testimony
The drug is prescribed for type 2 diabetes, especially for patients suffering from obesity and if there is no effect from the use of diet and exercise.
Metformin is used in adults and children aged 10 years and older, in the role of an independent medicament in combination with insulin or with other hypoglycemic medication for oral administration.
Rationale for use in obesity
For obese patients it is important to eat right and keep a regimen of physical activity. But only use these measures does not always produce results. According to the American Institute of Health, the body weight in 30-60% of patients returned to the original figure. Therefore, the treatment of obesity requires complementary approaches, one of which - pharmacotherapy.
Treatment of obesity with modern medical means has the following objectives:
- appetite suppression;
- decrease in revenue of excess calories in the body.
Metformin, according to the instructions for use, is not a drug for weight loss. But his property - the reduction in weight in patients suffering its excess leads to the effect - weight loss with metformin.
Another quality of metformin - antihyperglycemic not reduced when used alone glycemic levels below normal, enables use of the drug in humans - not diabetic at an early pathology of carbohydrate exchange.
The clinical studies have demonstrated effective weight loss for the past six months drug administration, and without dietary compliance regime and use of physical and sporting loads. Subtotal Metformin use in obesity is comparable with the effect of conventional drugs for weight reduction.
Act
Metformin is able to help in case of obesity, due to the following mechanisms:
- decrease in insulin concentration;
- increase in muscle glucose uptake;
- speedup of fatty acid oxidation;
- increase glycogenesis;
- prevention of fat deposits in the liver;
- decrease absorption of fat from carbohydrates;
- decreased appetite.
Contraindications
Metformin can be taken with obesity is not all.
According to the official instructions to the drug, the drug is contraindicated in the following cases:
- disease in the acute phase and chronic occurring which may cause the formation of tissue hypoxia (heart attack, cardiac and respiratory distress and al.);
- creatinine clearance (CC) of less than 60 ml / min .;
- alcoholism;
- clear pathology of liver and kidney;
- dehydration;
- intolerance to metformin;
- a severe infection;
- alcohol intoxication;
- use of intravascular contrast agents containing iodine.
Pregnant women and lactating able to use Metformin from obesity should not be. Also not recommended for use by patients aged 60 years.
application
Metformin treatment of obesity carried out in accordance with the instructions provided in the instructions to the drug. The optimal dosage regimen prescribed by the physician.
Metformin use during meals or after its use.
The dosage regimen:
Category patients |
A single dose, mg |
How many times a day |
Adults |
500 |
1-3 |
850 |
1-2 |
|
Children from 10 years |
500 |
1-2 |
850 |
1 |
side effects
As a result of the use of the drug Metformin obesity possible side effects.
List of the main symptoms:
- poor absorption of vitamin B12;
- flatulence;
- dysgeusia;
- nausea;
- lactic acidosis;
- diarrhea and vomiting;
- abdominal discomfort.
Very rarely hepatitis and fix the functional disorders of the liver. Possible dermal reactions as rashes and itching.
sources:
Vidal: https://www.vidal.ru/drugs/metformin-5
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = ac45cb5c-4394-42ca-8479-a60a7a67e0b0 & t =
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