Clotrimazole: the information on the medicinal product
Clotrimazole - antimicrobial and antifungal agent effective against Candida, dermatophyte fungi, Trichomonas vaginalis, Corynebacterium. Clotrimazole can be purchased at any drug store at an affordable price, and you can find a large number of analogs and generics. The mechanism of action of the drug associated with the ability to penetrate and destroy microbial cell cytoplasmic membrane. As a result, the pathological agent loses an opportunity to grow, develop and multiply and eventually die.
Means Clotrimazole is available in various pharmacological forms: cream, ointment, gel, drops, solution, vaginal tablets. After applying the medicament to the skin, mucous membranes or lesion, the active substance quickly and easily absorbed in the surface layer accumulates therein and practically does not penetrate into the blood direction. The drug takes effect after a few minutes, the effect occurs in a few days of continuous use.
The main indications for clotrimazole:
- candidiasis of female genital mutilation;
- inflammation caused by Trichomonas women;
- prevention of infectious complications of gynecological manipulation;
- skin diseases of fungal etiology.
Contraindications to the use of clotrimazole:
- intolerance basic substance and auxiliary components of the composition;
- allergic reactions in the past after the application or administration of Clotrimazole;
- the first months of pregnancy.
How do I choose a cream or ointment clotrimazole
To understand that better, clotrimazole cream or ointment, it is necessary, first of all, to look into the composition of the two formulations. The ointment contains 1 g of active substance an antibiotic, propylene glycol, polyethylene oxides of various kinds, nipagin. The cream contains the same amount of basic pharmaceutical substance, alcohols, polysorbate, distilled water and some other components. These materials provide a softer and less irritating consistency.
And a cream and ointment suitable for topical application, applied well, do not leave traces, available in tubes of the same size. The difference between a cream and ointment clotrimazole is their side effects - a burning sensation. After use on the mucous membranes of ointment with microtraumas on damaged skin the patient can experience discomfort, burning, local temperature can be increased. The cream has a milder effect due to the structure and air seldom causes side effects such.
cream advantage is that it also contains nutrients, softening the skin. The cream is applied thinly twice a day to the affected surface for a month. Ointment does not contain fragrances and additional components that improve the condition of skin. Polyethylene oxides enhance the viscosity clotrimazole, increase the activity of the basic substance. The ointment is considered more effective dosage form.
conclusion
by clotrimazole cream ointment slight contrast. The cream has a more airy and soft texture, contains a small amount of flavoring substances and feeding and softening the skin. The cream is useful for the treatment of diseases with lesions in the mucous membranes and genitals. Ointment contains no additional components caring for the skin, in its composition there are substances that enhance the pharmacokinetic properties, due to which the action of the ointment more efficiently. But when applying the drug to damaged skin and mucous membranes of the patient may feel a burning sensation and tingling.
sources:
Vidal: https://www.vidal.ru/drugs/clotrimazole__7002
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = 32297fe2-0ddb-4b7c-9af9-acb6183a8e12 & t =
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