The latest generation of statins. Name of the drugs, the properties, indications for use

High cholesterol - the problem of modern man, the supply is not always natural and healthy products. High cholesterol levels have a negative effect on the functioning of the organs, therefore needs to be adjusted and to bring back to normal. With this task cope statins - special drugs, cholesterol-lowering.

Statins: a group of drugs for cholesterol

High cholesterol increases the risk of heart attackIt violates the metabolic processes that adversely affect the internal organs. To normalize it uses special drugs - statins, which inhibit the activity of an enzyme such as mevalonate, contributes to the appearance of cholesterol.

Contemplated formulations are beneficial to the blood vessels, reduced cholesterol damaged wall, which is a good prevention of atherosclerosis and heart disease.

The first statin lovastatin were based onWhich is pretty well fulfilled its function. But science does not stand still, today considered the most effective of the latest generation statins (Name of the drugs will be given below), which positively proven in the medical practice.

The advantages of the latest generation of statins

Modern medicines that reduce cholesterol, based on components such as rosuvastatin and pitavastatin. These drugs have a distinct advantage over their predecessors: they are able to increase the concentration of "good" cholesterol in the blood.

Their effect is noticeable after a month of reception. "Bad" cholesterol is reduced and simply ceases to be produced by the body. In addition, a new generation of statins help even those patients who have not reached the previous generation products.

Regular intake of statins can reduce the possibility of developing cardiovascular disease, especially associated with cardiac system.

It's important to know! Statins assigns only a specialist. This is due to the fact that the dosage is calculated from test results on cholesterol. At rates of less than 6.5 mmol / l, medicines are not assigned, cholesterol adjusted a healthy lifestyle.

In some cases, prescribe the latest generation of statins

Cholesterol in the blood is always presentWhile it is important to monitor for the "bad" cholesterol, which component should not exceed 5.3 mmol / l.

If the concentration a little higher position, normalization occurs through diet, physical activity and refraining from bad habits: smoking and alcohol. If the above measures do not help to stabilize cholesterol, doctors prescribe the latest generation of statins.

The names of prescribed drugs may be different - their selection is made based upon individual rights.

Modern medicines at the lowest dosage can in the fastest time possible to improve the performance of cholesterol, normalize it. Which is beneficial to the body, prevents the occurrence of heart attacks and strokes.

In general, doctors recommend taking statins date in the following cases:

• After suffering a cardiac or stroke;
• In the presence of diabetes mellitus;
• If there is a predisposition to coronary artery disease;
• With a high degree of obesity;
• If statins previous generations did not have a positive effect.

Interesting fact! Statins are the last generation have been widely used in medical practice abroad, as effective preventing medicines for heart disease and blood vessels. Domestic same doctors, whatever name or had drugs, it is recommended to use them only in extreme cases, because of the emergence of a large number of negative phenomena.

Review of the latest generation of statins

Modern statins based on materials such as rosuvastatin and pitavastatin. They are stronger impact than the elements of previous generations, so available in the lower dosage.

Rosuvastatin - improves the lipid balance, A reduction of atherosclerotic plaques that are already present on the walls of blood vessels. However, it may adversely affect the body and manifest itself as a variety of undesirable effects on it.

Pitavastatin - has virtually no adverse effect on the organsAlso reduces the size of atherosclerotic formations, it minimizes the possibility of heart attack, stroke, atherosclerosis.

AKORT

The active substance AKORT drug - rosuvastatin, Auxiliary components are: lactose, calcium hydrogenphosphate, magnesium stearate. The drug is released by 10 and 20 mg, the amount of tablets in the stack is 30 pcs.

AKORT indicated for hypercholesterolemia: Primary, mixed and family, as well as the prevention of cardiovascular events, if there is a risk of their occurrence. Recommendations for the reception of the preparation: prior to admission need to follow a diet that lowers cholesterol.

Diet should be followed directly in the period of treatment medication.

Dosage is calculated individually, but usually physicians prescribe 10 mg (1 tablet) daily. Such dosage adopted for people taking statins past generations, and for those who come to this drug for the first time. At the discretion of the doctor, the dosage may be changed to 20 mg per day after 4 weeks of therapy.

If an increase in dosage does not bring positive results, and in more severe cases of the disease, it can be changed to 40 mg per day. However, a number of drug provokes unwanted manifestations, so the use of the drug in a dosage should be monitored by a physician.

It is not recommended to use 40 mg AKORT those patients who were not previously statin therapy. If the medicament in question is taken in dosages of 20 mg or 40, then after 2-4 weeks of treatment you need to pass additional tests to control parameters of lipid metabolism and kidney function.

Important to remember! Modern statins help bring cholesterol back to normal, but they should be taken throughout life. To remove the drug, cholesterol returns to its previous high level.

Crestor

Statin last generation - Crestor (product name) - as an active substance has rosuvastatin, Additional elements protrude cellulose, calcium hydrogenphosphate, magnesium stearate. The medicament is discharged through 5, 10, 20 mg, the amount of tablets in the stack is 28 pcs.

Crestor is prescribed for adults, regardless of race and gender in different types of hypercholesterolemia, as well as for the prevention of pathological conditions of the heart and blood vessels. The drug is approved for receiving diabetics.

Recommendations for receiving medication: 5 or 10 mg per day regardless of time of day and a meal at the same time the patient should observe a special diet. A tablet is not chewed, washed down with sufficient water. If after 4 weeks positive dynamics is absent, the amount of the drug is increased to 20 mg, and the control lipid metabolism.

In cases of severe hypercholesterolemia and possibility of having a stroke or myocardial initial amount increased to 40 mg per day. However Therapy should be supervised by a doctorSince it is possible the development of undesirable reactions.

In this requires constant monitoring of the functioning of the kidneys. Viewed medicament is suitable for the elderly, and the dosage not changed - 5, or 10 mg per day.

When kidney failure in acute use of CRESTOR is contraindicated.

Merten

Active drug component Merten - rosuvastatin, additional substances: magnesium hydroxide, magnesium stearate, cellulose. Produced medicament for 5, 10, 20 and 40 mg tablets in the stack 30.

Appointed by the drug in hypercholesterolemia and elevated concentrations of total cholesterol when diet food and other statins did not have a proper positive effect. Merten is also suitable for the elderly in the event of risk of diseases of the heart and blood vessels.

Recommendations for Admission:

• Compliance with the diet low cholesterol content, which begins prior to receiving the medicament and continues during therapy.

The administered dosage - 5 or 10 mg 1 time per day, taking a tablet, regardless of the meal, Washed down with sufficient amount of liquid. If cholesterol for 4 weeks is not normalized, the dosage is increased to 20 mg or 40 mg.

The patient should be under doctor supervision.

For older people the recommended amount is 5 mg 1 time per day. The same amount of medicament is prescribed for renal failure. The maximum dose - 40 mg at such pathology is prohibited.

Note! There are other drugs that are based the main active component - Rosuvastatin: Roxer, Tevastor, Rosuvastatin, NW, Rozart. These drugs have similar recommendations for admission as above discussed remedies.

Livazo

Pitavastatin - the latest generation of statins. The name drugs - Livazo. This is the most advanced drug, presented at the international pharmaceutical market. The main component - calcium pitavastatin, auxiliary elements: lactose, magnesium aluminometasilicate, magnesium stearate. Produced medicament to 1, 2, 4 mg, number of pills in the package is 14 pcs.

Livazo prescribed for primary hypercholesterolemia and mixed with family and type of the disease, when specifically selected diet, exercise and other non-pharmacological means have not yielded positive results, and cholesterol are not normalized.

Recommendations for Admission: considered prior to initiating therapy the drug and during treatment is necessary to stick to a diet, avoid foods that contain a low level of cholesterol.

Tablets washed down with sufficient water to form a whole, not chewed.

It is very important to stick to the exact course of the drug, doctors recommend taking Livazo evening at the same time. The initial dose is 1 mg per dayIf positive dynamics is absent, then after 4 weeks of daily amount of drug was increased to 2 mg.

The maximum dosage of 4 mg administered in cases of severe illness or no enhancements. Such an amount of the drug adversely affects the functioning of the kidneys, so therapy should be held under constant medical supervision and control over the work of this body.

If the kidney function, it is recommended to reduce the amount of medicament to 2 mg. For the elderly a special dosage adjustment is required, Also assigned Livazo in an amount of 1 mg per day, the dosage may be increased if necessary.

General contraindications to the use of statins

the latest generation statins (name of the drugs mentioned above) have a large number of contraindications. This is due to the fact that by inhibiting the production of cholesterol, medications disrupt the work of other organs of the body.

Besides, Cholesterol is needed to restore the cell membranesTherefore, it violates the oppression and lack of this feature, which can lead to the development of cancer.

In the appointment of modern statins, doctors take into account the contraindications listed in the table.

Statins are the last generation
names of drugs	Contraindications
Drugs with the main substance - rosuvastatin: AKORT, Crestor and other	Hypersensitivity of rosuvastatin and other components of the medication, the age of 18 years, the presence of muscle dysfunction and liver diseases. For the dosage of 40 mg additional contraindications: consumption of alcoholic beverages in large quantities, referred to the Asian race
Medicines with the active substance - pitavastatin: Livazo	Idiosyncrasy pitavastatin and drug excipients, lactose intolerance, age 18, myopathy, severe liver failure

All modern statins are contraindicated in expectation of the baby and breastfeedingAs the main components cross the placental layer and passes into breast milk, so they can have a negative impact on the future health of the child or are already born.

Not recommended statin therapy for women of childbearing age, in the absence of adequate contraception methods.

Be careful! Considered a statin should not be taken simultaneously with cyclosporine, as is additional pressure on the liver.

With caution and under constant medical supervision statins are assigned in the following cases:

• In renal failure;
• When thyroid disorders operation;
• If you are experiencing muscle failure in the use of the previous generation of statins;
• In the presence of pulmonary function disorders;
• Adults over 65 years.

Side effects with the use of statins

a new generation of statins were developed taking into account the risks and possible complications previous medication of this group. However, the utilization and clinical trials of drugs under consideration are not as long as other drugs, so identify any negative effects on the body difficult.

Classic negative manifestations which were strongly expressed in the statin past generations, - headache, decrease muscle activity in the gastrointestinal tract problems, modern preparations minimized by reducing the dosage of active substances.

To date, the latest generation statins (name of the drugs does not play a role, it applies to all drugs) have a confirmed list of complications.

Here they are:

1. Swelling, inflammation It arises from the effects of drugs on the liver.
2. The manifestation of asthma states.
3. Memory impairment occursViolated cognitive processes.
4. There is a constant fatigue, There is a weakness, there is a sleep disorder.
5. Allergic reactions, Especially in patients who are prone to allergies.

Maintain normal cholesterol is easy, it is necessary to monitor the nutrition, exercise and rest. If these methods do not help, you should start taking modern medicines - statins to help lower your cholesterol and keep it at the proper level.

Useful video of statins and the rules of their application

In the above video compilation contains additional important information about statins, are the names of the latest generation of drugs and advice on their use:

Good health and mood you every day!