A new generation of antipsychotic drugs without side effects. The name, a list of drugs for depression, neurosis, schizophrenia, autism, dementia in the elderly, epilepsy, whooping cough, panic attacks, pregnancy. Price, reviews

Antipsychotics - drugs for the treatment of psychiatric disorders. The new generation of atypical psychotics has virtually no side effects, allows you to save human mental activity does not prevent the social adaptation of the person after the completion of the course therapy.

Types of atypical antipsychotics

Antipsychotics - drugs for the treatment of various psychiatric pathologies, disorders of the nervous system, helping to:

• normalize the human social behavior;
• stop cough, nausea, vomiting;
• reducing body temperature;
• eliminate increased anxiety, insomnia;
• reduce autonomic reaction.

Previously used drugs for the relief of symptoms of schizophrenia, bipolar disorder completely blocked the metabolism of dopamine, causing a decrease in mental and physical activity. Atypical antipsychotics of new generation, in contrast to predecessors, have a mild effect, rarely provoke the appearance of adverse reactions.

Classification of atypical antipsychotics is based on:

1. The duration of the effect produced. In modern pharmacology antipsychotics produced rapid and prolonged action.
2. The severity of the clinical picture of treatment.
3. Mechanism of action of the medicament on dopamine nerve terminals (physician can select an appropriate therapy to the patient).
4. The chemical composition of the drug. Synthetic drug formula is chosen strictly individually, in order to reduce the possible unpleasant consequences of the treatment.

The efficiency of the new generation antipsychotics

a new generation of antipsychotic drugs without side effects that violate the intellectual work of the brain, have little antipsychotic activity. Effect on certain dopamine receptors in the brain. Unlike typical antipsychotics, reception of which leads to a complete disorientation human atypical neuroleptics are effective only in the limbic system.

They have low antidofaminovami properties, high sedative properties:

• eliminate overt and covert symptoms of psychosis;
• calm, reduce anxiety, vomiting reflex;
• inhibit the progression of disorders of the human psyche;
• no effect on the pituitary gland, extrapyramidal system, the hypothalamus;
• preserve cognitive function in full.

The advantages of atypical neuroleptics

a new generation of antipsychotic drugs without side effects for later personality socialization have a number of advantages compared with typical antipsychotics:

• keep the motor activity of the patient in full;
• did not impair fertility function ovulation potency;
• It does not affect the metabolism of dopamine;
• easily deduced from the human body;
• eliminate the symptoms of acute and chronic mental disorders;
• support mental functions of man;
• after treatment, allow return to normal life;
• not addictive.

Pharmaceutical companies have developed a number of drugs approved for the treatment of psychosis in pregnant women, juvenile patients.

Neuroleptics without the side effects: a review of drugs

The new generation of antipsychotic drugs, no side effects, prevents the development of mental disorders, maintaining cognitive function of man. Popular remedies:

Abilifay

The preparation is a capsule yellow-cream 10, 15, 30 mg. The active substance - aripiprazole.

The product has:

• high dynamism with respect to D2, D3-receptor, nerve endings 3NT1a, 5HT2A;
• moderate action to D4, 5NT7 receptors;
• not relieves muscarinic end.

It is indicated for:

• sudden outbreaks of schizophrenia;
• long-term treatment of chronic low-intensity decay of the process of thinking;
• sudden-onset bipolar disorder that followed the manualnym or mixed episode.

Medication consumed one-time, regardless of food consumption. The dosage is set by the doctor individually for each patient.

Recommended treatment:

1. Schizophrenia (Acute attack, chronic). In the first week registers - 10-15 mg / day. After improving the daily dosage of the drug drops (10 mg).
2. Bipolar disorder - 15-30 mg / day.

"Abilifay" instantly absorbed by the digestive tract. The highest concentration in the blood observed after 3-7 hours after ingestion of the capsule. The positive effect of the drug activity is shown to the 14th day after the start of therapy. It is metabolized in the liver completely excreted from the decomposition products.

Medication is not used in patients with:

• having intolerance to any component of the formulation;
• under 18 years of age.

Contraindicated in pregnant women and nursing mothers.

Be wary conducted drug therapy "Abilifaem" persons suffering from:

• cardiovascular disease;
• violation of the gastrointestinal tract functions;
• endocrinological disorders;
• chronic respiratory diseases;
• suicidal tendencies;
• renal, hepatic insufficiency.

Adjustment of psychiatric pathologies in patients older than 65 years do not require changing the standard dosage.

fluphenazine

One of the best modern antipsychotics. Relieves nervous irritability, eliminates the symptoms of mental illness, hallucinogenic disorders.

Building blocks:

• fluphenazine decanoate;
• benzyl alcohol;
• sesame oil.

The preparation is a suspension for a. / M. Injection of a pale yellow, oily character.

It is indicated for the treatment of:

• acute schizophrenia;
• circular psychosis;
• hyperactivity;
• increased nervous excitability;
• disorders of mental functioning dynamics.

Demonstrates antipsychotic effects. Prevents the D-receptors in the brain dopaminergic system.

It has:

• antiemetic action - is active with respect to D2-endings, the vagus nerve in the gastrointestinal tract;
• antihypertensive properties - frees the hypothalamus, pituitary hormones;
• the reinforcing effect with respect to developing prolactin;
• ekspiramidalnym low impact.

The body "Fluphenazine" active substances decompose, connecting with the plasma protein.

The treatment of the patient selected individually depends on personal characteristics of the patient, the type, stage neural pathology.

The recommended dosage for adults:

• orally - 1 - 5 mg 2-3 times a day (total of not more than 20 mg);
• / m injections - from 1.25 to 2.5 mg every 6-8 hours.

Minors "Fluphenazine" is prescribed as a "demo form" - 250-750 mg / kg (1-4 times daily). A maximum of 100 mg. Treatment is mandatory to conduct courses with an interval of 14 days.

The drug rarely causes addiction, development of adverse pathologies.

Contraindicated for use by persons suffering from:

• loss of consciousness with complete cessation of respiratory activity;
• disorders of cerebral circulation;
• abnormalities of the heart and blood vessels;
• blood disease;
• depression;
• disturbances in the liver and kidneys.

Not prescribed for the treatment of women waiting for the baby and breastfeeding mothers.

When co-administered with antispasmodics may depress respiratory function, central nervous system work. It enhances the effect of alcohol, psychotropic substances.

quetiapine

The safest antipsychotic. Not addictive. The emergence of side effects occurs only in excess of the maximum allowable amount to take daily medication. In pharmacology "Quetiapine" represented by the convex capsules white shade.

Components:

• quetiapine;
• polisorb;
• milk sugar;
• sodium carboxymethyl starch;
• povidone K-30;
• talc;
• magnesium salt;
• cellulose silicon dioxide.

Antipsychotic. The most active towards serotonin 5HT2 endings, to less than D1, D2- receptors. It does not cause an increase in the number of prolactin. It has a bright antisioliticheskoe action. Blocks anti-histamine H1 receptor. It is absorbed by the gastrointestinal tract. Combined with plasma proteins. Actively dissolves in the liver.

It is indicated for acute and chronic mental disorders with different etymology strong antisotsiologicheskoy orientation.

Mode of application:

• adult - 50 mg / day .;
• elderly people - one-time 25 mg per day;
• persons suffering from chronic dysfunction of the liver and kidney - 25 mg.

With daily consumption dose "Quetiapine" increases over time (up to 700 mg).

It is forbidden to prescribe medication:

• persons suffering from hypersensitivity to the constituent components of the drug;
• young children;
• pregnant women;
• nursing mothers.

Flyuanksol

Antipsychotic, produced in the form of:

• tablets brownish-yellow, sugar-coated;
• liquid / m administration.

Thioxanthene derivative:

• reduces the excitability and psychomotor activity;
• It has the releasing action;
• It reduces anxiety and fear;
• prevents the development of depression;
• It weakens the activity of dopamine receptors (D1, D2).

The effectiveness of therapy depends on the dosage of the drug. The duration of exposure tablets from 2 to 4 weeks.

Building blocks:

• flupenthixol dihydrochloride;
• magnesium stearate;
• gelatin;
• lactose monohydrate.

Once in the body, the drug is cleaved in cis-flupentixol and capric acid. Conclusions intestine.

The dosage chosen for each patient depending on personal characteristics, current stage of disease.

Assigned "Flyuanksol" in an amount of up to 3 mg / day. for elimination:

• depressive mental disorders, followed by apathy;
• chronic neurological problems disturbing nature;
• stressful conditions;
• psychosomatic disorders with asthenic reactions.

Prescribed rate of 3 to 40 mg / day. patients suffering from:

• paranoia with delusions;
• hallucinatory syndrome;
• reduction of mental activity;
• apathy, autism.

The dosage of 40 to 150 mg / day. for the relief of:

• psychiatric disorders character;
• neurological and physiological dysfunctions arising from the manifestation of withdrawal symptoms in patients suffering from alcohol addiction.

The maximum number of allowed medications - 150 mg / day. divided into 3 doses. When the / m injections - up to 200 mL with an interval of 2-4 weeks.

Medication is not used in patients suffering from:

• acute drug, alcohol intoxication;
• hyperthermia;
• Parkinson's disease;
• fever;
• allergic reactions to components of the formulation;
• dysfunction of kidney and liver.

"Flyuanksol" is contraindicated in:

• patients having a history of toxic agranulocytosis;
• pregnant women;
• nursing mothers.

triftazin

Medication to eliminate psychosis secondary phenothiazines.

It used to control:

• various psychotic disorders;
• neuroses, accompanied by anxiety, fear;
• nausea (reduces expression of the gag reflex).

Contained in the slurry for / m trifluoperazine injection freezes mesolimbic D-postsynaptic receptors located nervous system.

It shows:

• emetic reflex lowering (by eliminating the activity of D2-receptor pair gastrointestinal nerve);
• alpha-adrenoceptor blocking activity;
• hypotensive effect.

Reception "triftazin" to a small extent and reduces cerebral labor patient activity.

The dosage of the drug is prescribed individually:

• adults - 1-5 mg every 8-12 hours;
• children - 1 mg (2-3 injection per day).

Restrictions apply to:

• deep fainting with loss of breath;
• depression;
• oncology;
• shortness of breath;
• shaking palsy;
• renal dysfunction;
• the waiting period of the child;
• breast-feeding;
• epilepsy;
• peptic ulcer disease.

For the treatment of individuals after 70 years set a reduced dosage.

Levomepromazine

The drug is available as a tablet, solution for intramuscular, intravenous administration. Phenothiazine. Included in the list of ZHNVLN.

Once in the body medicine:

• conducts sedatives, antipsychotics, antiemetics, antihypertensive action;
• suppresses depression, without affecting the brain and mental activity of man;
• enhances the production of pituitary prolactin;
• It merges with plasma protein (maximum concentration is shown after 1-3 hours);
• output intestines, kidneys.

Medications shown at:

• Mental and motor skills, accompanied by severe irritability;
• Circular psychosis;
• schizophrenia;
• senile dementia;
• seizures induced by psychotropic, alcohol dependence;
• depression, followed by anxiety, restlessness;
• neurological problems;
• sleep disorders;
• severe pain caused by inflammation of triple nerve, shingles, oncology;
• itching dermatoses.

The dosage regimen:

• adults need to consume 25-50 mg;
• children prescribed 15 mg / kg / day. 2-3 times;
• injections - 24-50 mg.

Limited use of the drug in patients suffering from:

• decompensated disorders myocardial functions;
• essential hypertension;
• pathologies of the circulatory system;
• disorders of the kidney and liver.

Pregnant women are prescribed the minimum dose. By the due date the amount of the preparation used is reduced in order to avoid the development of atropine effects in a newborn baby.

With caution "levomepromazina" administered:

• children;
• To old people;
• oncology patients;
• persons suffering from Reye's syndrome, Parkinson's disease, chronic dysfunction of the respiratory system;
• epileptic patients.

Neuroleptics without the side effects that can be bought without a prescription

a new generation of antipsychotic drugs without side effects in relation to the nervous and endocrine systems are widely used to eliminate neurological, psychotic disorders. Medicinal properties of drugs aimed at blocking dopamine receptors D1, D2, reduction in hyperexcitability, anxiety.

The above list of antipsychotics has a sedative effect, used for depression and stress, sleep problems:

1. "Olanzapine" - reduces the effect of neuronal activity calms the nerve pathways that control motor function. Removes the anxiety, the negative effects of stress. It is indicated for depression, psychiatric pathologies, increased fear. You should not take the drug for pregnant and lactating women, children under 18 years of age, persons suffering from diseases of the blood, liver and kidneys.
2. "Amisulpride" - a sedative neuroleptic, antidepressive action. It is indicated for schizophrenia, mental pathologies accompanied by delusions, hallucinations, thought disorder, withdrawal.
3. "Aprizol" - used to treat psychosis. It acts on dopamine receptors and sedatives. It relaxes the nervous system. The maximum drug effect occurs 4-5 days after initiation of therapy. It is recommended for depressive disorders. It can be dangerous for patients with pathologies of the cardiovascular system.
4. "Serdolekt" - generic "Aprizola". Similar in composition and therapeutic effects.
5. "Respiridon" - a psychotropic drug with hypothermic, antiemetic, sedative effect. Good overcomes mental disorder accompanied by delusions, hallucinations, neurological problems, the effects of stress, depression. Appointed with hydrocyanic dementia Alzheimer's type, senile dementia, uncontrolled aggression teenagers.
6. "Clozapine" - antipsychotic, eliminating anxiety, destructive behavior. It acts on negativity symptoms of schizophrenia, manic-depressive psychosis, psychomotor agitation, emotional and behavioral type of bipolar disorder.

The price of drugs in pharmacies of Moscow, St. Petersburg, regions

A new generation of antipsychotics, without side effects for the subsequent activity of the human brain are implemented in the pharmacy network of the Russian Federation. The price of the drug depends on the region, transportation costs, the supplier.

Name of the village	"Abilifay"	"Quetiapine"	"Flu-anksol"	"Triftazin"	"Olan-faltering"	"RISP-ridon"
Moscow	7382	213	386	77	160	129
St. Petersburg	4200	294	357	34	226	70
Amurskaya Oblast	12000	650	415	98	158	136
Arkhangelsk region	5300	994	384	76	218	167
Belgorod region	11800	657	379	33	422	120
Bryansk region	6300	218	432	35	338	117
Lipetsk region	11800	212	370	29	422	130
Voronezh region	6297	188	411	26	160	106
Ivanovo region	12900	216	397	35	335	113
Rostov region	5400	217	381	24	204	165
Kaliningrad region	6298	218	990	29	216	136
Vologodskaya Oblast	6298	219	384	32	218	126
Irkutsk region	6298	216	590	24	190	140

The new generation of antipsychotic drugs helps to cope with mental and neurological disorders. Modern antipsychotics do not have adverse effects on mental and physiological activity of the person. Picking up individually in each case in a timely manner cropped mental defects not preventing further social adaptation of personality.

Registration of the article: Vladimir the Great

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