Sometimes during the treatment of infectious disease, patients are interested in how high the compatibility of omeprazole and antibiotics. This occurs most often during treatment of gastritis associated with Helicobacter pylori. Also, after taking antibiotics Omeprazole is recommended to stimulate the resumption of normal microflora in the gastrointestinal tract (SHKT).
The mechanism of action of omeprazole
This preparation - is an inhibitor or repressor, proton pump (PPI). He acts by blocking an enzyme required for the final phase of the secretion of hydrochloric acid (HCl) - H / K-ATPase. This is done in the lumen of the tubules of parietal cells of the gastric mucosa.
Take Omeprazole with antibiotics is necessary to half an hour before meals. The capsule should be swallowed whole, not liquid, squeezed with sufficient water.
A state where the reception omez and antibiotics required
If a patient with gastritis, the formation of ulcers or duodenal ulcer, specialists prescribe a comprehensive treatment with medications:
- omeprazole;
- clarithromycin;
- Nitroimidazole (metronidazole);
- Amoxicillin.
For Helicobacter pylori eradication therapy, this is one of the most effective. Yet before taking omeprazole and antibiotics, you must go through a number of laboratory and instrumental studies, consult a doctor.
Why drugs are prescribed together
Because omeprazole reduces acidity of gastric contents, the action of antibiotic drugs is increasing. Drug combination effective to eliminate propagation dividing microorganisms and omeprazole with antibiotics contributes to antimicrobial drug activity.
To reduce the negative effect such amounts of drug to the stomach and may have a cementitious formulation De-Nol (colloidal it includes bismuth subcitrate). It is also used to stimulate healing formed deep and superficial defects organ mucosa. It is via the formation of chelate compounds, precipitates proteins and thus creates a thin protective film. The preparation normalizes the acidity and thereby minimizes damage from omeprazole and antibiotics.
Contraindications to the use of omeprazole and antibiotics
Often there are diseases that require antibiotic therapy, incompatible with omeprazole. Among such diseases tuberculosis. It is caused by acid-fast bacilli - tubercle bacillus. These organisms are not sensitive to most drugs, so the approach to the treatment of the disease is necessary with maximum responsibility. Rifampicin - an antibiotic to kill mycobacteria. It is not compatible with omeprazole, as they reduce the activity of each other and the efficiency of the treatment is significantly reduced.
Also, these antibiotics in combination with proton pump inhibitors are contraindicated during pregnancy. This is due to teratogenic effects on the fetus and the development of abnormalities in the baby.
Thus, not all antibiotic drugs are compatible with the reception omez. In addition, the period of treatment should not drink alcohol as it will negatively affect the healing process. Omeprazole provides recovery after antibiotics normal environment in the gastrointestinal tract organs.
It is important to remember that any treatment has consequences. To avoid this, you must adhere to the doctor's recommendation, not to miss a dose, to prevent the development of bacterial resistance to antibiotics.
sources:
Vidal: https://www.vidal.ru/drugs/omeprazol__3120
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = 83097c54-4fcd-4122-b96d-1b90b38d8823 & t =
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