There are cases where patients must be treated at the same time the digestive tract diseases, and various inflammations. Therefore, they want to know how to take omeprazole and diclofenac. These drugs belong to different pharmacological groups.
Mechanisms of action of omeprazole and diclofenac
Diclofenac - the drug groups nonsteroidal antiinflammatory drugs (NSAIDs).
It is used to relieve inflammation and pain. The mechanism of action is due to:
- inhibition of the enzyme cyclooxygenase (COX) in the conversion of arachidonic acid;
- inhibition of production of prostaglandins.
Injections of the drug are shown in osteochondrosis, the use of rectal suppositories - hemorrhoids. If a tablet taken orally, as well as injections observed ulcerogenic effect, that is, the formation of ulcers. A similar effect has a drug with the same group - Naproxen.
Omeprazole and its analogue Omez - this means that belong to the proton pump inhibitor, or the pump (PPI). The action based on blockade of the enzyme H / K-ATPase. He needs to complete during the last phase of the formation of hydrochloric acid, parietal cells in the stomach. It is indicated for organ damage mucosal gastritis, peptic ulcer disease, medication (antibiotics, nonsteroidal anti-inflammatory drugs).
From this perspective, taking Diclofenac with Omeprazole should be appointed in order to prevent the formation of gastric mucosa defects. Also proton pump inhibitors have no effect on the concentration of anti-inflammatory drugs in the blood.
Methods for receiving and dose
Injections of omeprazole with diclofenac doctors often prescribed together. They do this in order to ensure adequate treatment of inflammatory diseases and to prevent gastric mucosal lesion.
Diclofenac in a solution for injection is applied intramuscularly, once, 75 -150 mg. In tablets, as the maximum daily dose to about 150 mg, it is to be divided into 3 doses. Rectal suppositories are used 1 100 mg once daily, 50 mg, 25 mg - 2-3 times / day.
Omeprazole in the form of tablets of 20 mg taken once a day. Apply it should be in the morning and 30 minutes before meals with plenty of water. Omeprazole drink while taking Diclofenac is important throughout the course of therapy, anti-inflammatory drugs.
Due to the fact that the drug accumulates in the tubules of gastric glands and blocks the enzyme, the development of hydrochloric acid is inhibited as long as not recover secretory cells. In the case of omeprazole it is time - 20-23 hours. Throughout the drug stomach is protected from the adverse effect of diclofenac on the mucosa. You can also take Omez in the case of regular treatment theophylline, since it provokes an exacerbation of peptic ulcer disease. And in the case of diclofenac therapy stimulates the production of mucosal defects.
Contraindications to receiving
Any number of drugs have contraindications or conditions in which their use is not recommended or required careful examination and consultations with the specialist.
Do not take Diclofenac if there is:
- pregnancy;
- up to 6 years;
- lactation;
- proctitis;
- peptic ulcer gastro-intestinal tract.
Omeprazole is contraindicated in such cases. If administration is required - it is necessary to consult a doctor and not self-medicate.
Thus, PPIs including omeprazole, it is necessary to minimize the risk of digestive tract diseases. The main thing to remember that drugs can have negative results. To prevent this - before taking any means necessary to consult an experienced physician.
sources:
Vidal: https://www.vidal.ru/drugs/omeprazol__3120
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = 83097c54-4fcd-4122-b96d-1b90b38d8823 & t =
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