Amoxicillin, clarithromycin and omeprazole - the active components of a combined preparation, which is used in the treatment of gastric ulcer and duodenal ulcer. Its effectiveness is also proved in the fight against Helicobacter pylori infection.
According to international classification, this antibiotic belongs to the group of "anti-ulcer drugs", applicable in the treatment of reflux disease of various origins.
Omeprazole - a drug inhibitor that is effective in reducing the acidity in the stomach.
Auxiliary components of capsules:
- clarithromycin - a semi-synthetic antibiotic belonging to the macrolide group;
- amoxicillin - an antibiotic of the penicillin group polysynthetic.
Collectively taking amoxicillin with clarithromycin and omeprazole is necessary, as the drug itself is designed for comprehensive treatment.
Combination drug components
A combination of amoxicillin with clarithromycin has a positive result and antimicrobial effect. All components effectively fight infection pilobakte by the active substance in the preparation. As the active substance omeprazole stands and the other two - auxiliary.
Thanks to the triple therapy can achieve 85-95% eradication of Helicobacter pylori. This result is considered to be the highest among the most similar drugs STI group.
Triple therapy introduced only recentlySince before 1994 Helicobacter pylori studied little problem. The effectiveness of triple therapy is that it is antibiotics (amoxicillin and clarithromycin) neutralized hearth propagation of bacteria, and a basic substance omeprazole supports favorable environment in the stomach.
Indications and contraindications
Therapy comprising omeprazole, clarithromycin and amoxicillin is used in the treatment of:
- Infection Helicobacter pylori;
- duodenal ulcer and stomach;
- reflux esophagitis.
If these indications prescribed medications, it also negotiates a dose and time of administration. The treatment lasts a long time, one pill will not help. For example, in peptic ulcer reception preparation is up to 8 weeks, and the dose of the drug up to 40 mg / day.
Take drugs together is not recommended:
- people are intolerant drugs;
- pregnant and lactating women;
- simultaneously with other agents of this group of drugs;
- patients with impaired liver function.
As side effects with prolonged use of the drug, people may experience headache, constipation, flatulence, diarrhea, pain, and abdominal cramps, vomiting and nausea. Adverse reactions are rare, mainly in people who drink three drugs at the same time (except complex).
Why triple therapy may not work
If we compare drug omeprazole with clarithromycin and amoxicillin, it is the most effective drug in the fight against Helicobacter pylori, however, 100% eradication is still not observed. This is due mainly to:
- small concentration of drug in the mucosa;
- bacteria resistant to certain components of the drug;
- tablets reduction activity during long-term treatment;
- failure to comply with doctors' prescriptions;
- appearance in the body of some bacteria strains not previously studied.
In spite of the above contraindications, and a small percentage of eradication of Helicobacter pylori, triple therapy is considered to be the most effective in the treatment of this disease. The price of the drug to the three components higher than usual omeprazole, but it should not be the deciding factor when choosing a medication.
sources:
Vidal: https://www.vidal.ru/drugs/omeprazol__3120
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = 83097c54-4fcd-4122-b96d-1b90b38d8823 & t =
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