Arisept is an effective remedy for Alzheimer's and dementia

Arisept( Aricept ) is a drug that refers to inhibitors of acetylcholinesterase of a selective type of action.

A medicament is used for organic disorders of the cerebral cortex, for the treatment of dementia and Alzheimer's disease.

The drug is produced in tablet form, the tablets are rounded and the organic membrane is a film, the standard dosage is 5-10 mg.

One tablet contains in its chemical composition:

• donepezil hydrochloride 5-10 mg;
• auxiliary chemical components: giprolose, starch, lactose, cellulose, magnesium.

mechanism of pharmacological action

Antiholinesterazny drug inhibits the action of cholinesteraseon the cerebral cortex, is capable of blocking the disintegration of a specific mediastinand acetylcholine, which is responsible for the excitation processes of transmission along the nerve fibers.

Already with a single dose of medication, the cholinesterase activity slows down by approximately 78%.The drug is able to slow down the destructive processes in the brain, and reduces symptomatic manifestations in Alzheimer's disease, among which apathy, blurred memory and uncontrolled motor activity.

Pharmacokinetic properties of

After oral administration of the drug in blood plasma, the maximum concentration of the active substance is already observed after 3-4 hours, the consumption of food does not affect the absorption process.

Removal of the drug from the bloodstream occurs approximately 70 hours after admission. How the active ingredient is distributed according to the tissues of the body remains to be studied, but it is known that the metabolic substances remain in the human body for 7-10 days.

The primary metabolic process occurs in the liver, the drug is 95% bound to plasma proteins. It is excreted from the body in large measure by the kidneys, 20% is excreted with fecal masses.

Indications and contraindications to the use of

Aricept medicament is applied:

• in Alzheimer's disease 1-3 degrees of severity, to alleviate symptomatic manifestations, as well as facilitate general care of patients;
• with senile or post-traumatic dementia in order to improve the cognitive function of the measles of the brain.

Interesting and informative about Alzheimer's:

Absolute contraindications for the use of medication:

• hereditary lactose intolerance;
• in combination with drugs of a similar mechanism of action;
• children under 18 years;
• in case of violation of the cardiac conduction system;
• for acute or chronic pulmonary pathologies;
• during pregnancy and lactation.

Treatment Scheme

Aricept is applied orally 1 time per day. The first dose should be taken in a dosage of 5 mg, this dosage should be followed for 6-7 weeks in order to achieve an equilibrium concentration of the drug in the blood plasma.

After the patient undergoes a general clinical examination, the dosage is increased to 10 mg. The medicine does not affect the function of the liver or kidneys, it has a selective mechanism of action.

Cases of overdose

In case of an overdose, the symptomatic signs develop:

• dyspeptic manifestations in the form of nausea and vomiting;
• hypersalivation of the salivary glands;
• increased sweating;
• reduction in heart rate;
• sharp decrease in blood pressure indicators;
• convulsive contractions of muscle fibers;
• weakness of the contractile function of skeletal musculature;
• inhibition of respiratory function.

Medication correction of overdose includes the introduction of a specific antidote, Atropine. Hemodialysis and hemofiltration procedures may be used.

Possible Adverse Reactions

On the general condition of a person:

• tenderness in the lower jaw and chest;
• apathetic mood;
• weakening of the immune system;
• fever.

The nervous system can react as follows:

• aggressive state;
• delusional disorder;
• hallucinations;
• aphasia;
• ataxia;
• Neuralgia of peripheral nerves;
• is a dermatitis of neurogenic origin;
• drowsiness;
• irritability and nervousness.

Crashes in the CCC( cardiovascular system):

• spasmodic arterial pressure;
• blockade of the conductor system;
• reflex heart failure;
• thrombotic lesion of vessels of the venous bed.

Respiratory system:

• pain and sore throat;
• expiratory dyspnea;
• blood stasis in the parenchyma of the lung tissue;
• pathological respiration;
• the fall of the lung.

Urinary system:

• no urine;
• the act of an emiction is broken;
• oppression of the contractile function of the muscular fibers of the bladder.

Specific instructions

Drug Arisept should be prescribed only by a qualified neurologist.

If no positive effect is observed after prolonged use of the medication, then it should be discarded. The withdrawal of the drug should be carried out gradually, a sharp refusal is strictly prohibited.

When combining Arisept with drugs for general anesthesia, muscle relaxancy of the smooth muscles of the bronchi may develop and, as a consequence, stop breathing movements. It is not recommended to consume medicinal product before long automobile journey.

Interaction with other drugs and alcohol

Arisept belongs to a new generation of medicines, its therapeutic effect and compatibility with other medicines are not fully understood.

It has been proven by experience that drugs such as Levocom, Quetiron and Amantine are absolutely compatible with Arisept, this is proved by a practical medical research that was conducted during the month. The result showed that there is no negative interaction.

Drugs such as rifampicin, phenytoin, carbamazepine and alcohol mellitus in combination with anticholinesterase drugs cause a sharp drop in blood pressure and exacerbate side effects.

Price and analogues

The price of Arisept 6000-8000 rubles depending on the dosage and the specific pharmacy network, analogues are also available:

• Divar;
• Alzepil;
• Jasnal;
• Alzamed;
• Aripesyl;
• Donerum;
• Servonex;
• Dementis.

The drug should be stored in dry and dark places, it is necessary to limit access for children. The storage period is not more than 3 years.

It is released only by prescription from a neurologist.