Bisoprolol. Instructions for use, price, reviews, analogues

Bisoprolol (bidop) - a drug for lowering blood pressure, treatment of tachycardia, ischemia, myocardial infarction. According to the instructions for use, bisoprolol has a large spectrum of activity, is required for adjustment of drug problems of the cardiovascular system.

Structure and Composition

Medicinal agent is in the form of spherical capsules beige, pale blue or pink color, a palette changes in the ratio of the density of the active substance therein, with a dividing strip for more convenient dosing.

The constituent components of the drug:

• bisoprolol fumarate - basic substance possessing antianginal, antiarrhythmic, antihypertensive action.

Additional parts:

• microcrystalline cellulose;
• digidrofosfornokisly calcium;
• corn starch;
• silica;
• polyvinyl alcohol;
• titanium dioxide;
• Opadry II;
• magnesium stearate;
• sodium starch glycolate type A.

pharmacological properties

Bisoprolol: User application based on active properties fumarate capable of blocking receptors cardiac cells, reducing their acute contractile reflex adrenaline reset.

Thereby:

1. Reduced heart rate, the weakening of the need for myocardial oxygen and nutrients. It stops the occurrence of pain due to poor revenue blood cells to the heart muscle.
2. No bright response to adrenalin receptors, reduced vascular tone walls lumen extends.
3. Lowers blood pressure.

95% of the drug is absorbed through gastrointestinal tract. The therapeutic effect starts after 35 min. from the moment of consumption. The active ingredient gets into the nerve cells, the placenta and breast milk.

Part of the drug is metabolized in the liver, 85% of excreted by the kidneys within 12 hours. The therapeutic properties of the drug persist for days.

Indications

It is used for chronic treatment with:

1. Hypertensive heart disease, caused by the steady rise in blood pressure for a long time. Most often, this dysfunction is accompanied with an increase in atherosclerotic plaques on the walls of blood vessels. Not applicable for hypertensive crisis to a rapid decrease in pressure.
2. Ischemia - a disease state characterized by the inability of the coronary vessels to cope with the need heart of oxygen and nutrition. Characterized by cramping pains in the side of the heart with active loads of emotional stress.
3. Tachycardia.
4. The risk of myocardial infarction and as therapy side effects after surgery on the heart.

Dosing and dosing regimen

The treatment regimen selected individually in accordance with the indications. Therapy is conducted under the strict supervision of the treating cardiologist, daily measurement of blood pressure level. Before the course should make the cardiogram and repeat the procedure at least 1 time in 2 weeks.

A tablet taken orally, once daily in the morning before eating, drinking plenty of fluids. The maximum daily dose not exceeding 20 mg. For a small excess BP appoint 0,025 g When expressed in the pathology of the liver and kidneys should be consumed to 0.01 g the drug per day. Angina, ischemic disease the recommended dosage of 5 - 10 mg.

Increasing the concentration of receiving the daily amount of drug should be gradual:

• 1 week - 1.5 mg. (1/3 tablets);
• 2-3 weeks - 3.5 mg;
• starting from the 4th week, the dose is increased to 5 mg;
• 5-6 weeks - 7.5;
• 7 minutes - 10 mg.

Complete the course of treatment should be gradual, in reverse order.

Unlike schemes reception of various drugs Bisoprolol

Dosage regimens in various pathological conditions:

• hypertension in the early stages - 2.5-5 mg .;
• the second stage of the disease - 2.5 -10 mg .;
• stable angina - 2.5-5 m .;
• treatment of heart disease complicated with liver or renal dysfunction - less than 10 mg .;
• heart failure:
• 1 week - 1.25;
• 2 week - 2.5;
• Week 3 - 3.75;
• 4 - 8 weeks - 5;
• 9-12 – 7,5;
• from 13 - 10 mg. per day.

Side effects of the drug

Bisoprolol: using instruction prescribes clearly adverse pathology, whose appearance is probably prolonged dosing or drug abuse.

From the nervous system:

• dizziness;
• headache;
• sleep disturbance,
• confused in the mind;
• depression;
• constant apathy and fatigue syndrome;
• occasionally occur hallucinations, tremors of the limbs.

Cardiovascular problems:

• arrhythmia;
• strong and sharp pain in the heart;
• hypotension.

GI:

• nausea;
• vomiting reflex;
• problems with a chair;
• changing tastes;
• liver dysfunction.

ENT organs:

• nasal congestion;
• spasm of the bronchial tubes and lungs.

Organs of vision:

• dry eyes;
• conjunctivitis;
• impaired vision.

Circulatory system:

• reduction of platelet count;
• increase in white blood cells.

Skin reactions:

• rash;
• psoriasis;
• a rash without itching and irritation.

Endocrine system:

• thyroid dysfunction;
• changing the amount of dextrose in the blood fluid.

Allergic reactions:

• itching;
• hives;
• Angioedema;
• anaphylactic shock.

Discomfort in the lower back, painful joints. Lack of sexual desire, impaired potency.

main contraindications

Admission is prohibited when:

• presence of a strong sensitivity to the constituents of medical equipment;
• decompensated heart failure;
• cardiological shock;
• bronchial asthma;
• bradycardia;

• abstruktivnoy pulmonary disease;
• sinoarterialnoy blockade;
• pheochromocytoma;
• Raynaud's syndrome;
• hypotension;
• patients under 18 years anniversary;
• psoriasis.

optional contraindications

Therapy bidopom performed carefully under close supervision of a cardiologist if the patient:

• acute and chronic dysfunctions of the liver and kidneys;
• diabetes;
• while waiting for the child;
• breastfeeding;
• giperterioza;
• congenital atelokardiya;
• myocardial infarction;
• Prinzmetal angina;
• compliance with a low-carb diet.

Action tablets is manifested in inhibition of the central nervous system, especially at the stage of habituation to the medicament. People who drive a vehicle involved in the work, requiring reinforced concentration and precision of action, you must be extremely careful during therapy Bisoprolol.

Overdose

With an overdose of the drug may occur:

• arrhythmia;
• quickly lower blood pressure;
• shortness of breath;
• bronchospasm;
• severe bradycardia;
• you're blue hands;
• fainting;
• dizziness;
• convulsions.

When the above-described pathological states need urgent medical assistance, which consists in the purification stomach against toxins, treatment of absorbents, medication adjustments exhibit symptoms listed diseases.

Precautionary measures

During the appointment and conduct of drug therapy following precautions need to be observed:

1. Bisoprolol must be used for a long time, to avoid abrupt withdrawal of tablets, especially ischemia, myocardial infarction.
2. Before assigning, in the course of treatment, patients are shown daily measurement of blood pressure levels, especially during the first 7 days. Undergo ECG - at least every 1-3 weeks to monitor heart rate. Readings of less than 60 beats over 1 minute require discontinuation bidopa).
3. It is mandatory to control the level of glucose in the blood fluid, especially in patients with disruption of the endocrine system and the diagnosis "diabetes type 2 diabetes insulin-dependent type."
4. In old age, using bisoprolol, you must continuously monitor adrenal function (weekly pass clinical and diagnostic examination of urine).
5. Before prescribing physician necessarily must examine the respiratory activities, assign a control X-ray light, particularly in patients who have a tendency to bronchopulmonary pathologies. This measure is intended to exclude the possibility of increasing the blocking action Bisoprolol. Sufferers nicotine addiction may be faced with low therapeutic effect of the drug, in combination with the products of the tobacco decay.
6. Components of the drug can provoke strong sensitivity to external allergens become rise to anaphylactic shock, or angioedema.
7. Before surgery should stop drinking bisoprolol not less than 48 hours prior to submission of general anesthesia. Against the background of the active components used to complete anesthesia, bisoprolol can trigger receptor blocking amplification reaction of the heart muscle.
8. The drug is prohibited combine with calcium antagonists, diuretics, nitrates and other anginoblokatarami.
9. In simultaneous treatment with bisoprolol and Clonidine to stop the use of the first to be only 4 days after the last cancellation.
10. In the treatment of patients suffering from adrenal oncology requires weekly status monitoring function of the urinary system, mandatory registration at the oncologist.

How to take, instructions

Bisoprolol - instruction manual recommends a one-time taking the drug in the morning before eating or during breakfast. The tablet is swallowed completely washed down with liquid.

The amount of drug is determined individually according to the disease requiring medical corrections, the general state of the patient, presence of concomitant pathologies.

Most often assigned 5 mg. only once, at day with a maximum dose must not be more than 20 mg. provided good tolerability tablets. Bidopom therapy in elderly people is no different, except compulsory control the amount of glucose in the body is not less than 1 time in 14 days.

The most commonly prescribed pills to young people who prefer active life, because of the rare occurrence of undesirable effects and the ability to maintain an optimal level of blood pressure, both at rest and physical time actions.

In accordance with the state of health of the patient, taking the drug the internal organs, the physician may adjust the dose.

Pregnancy and breast-feeding

Instructions for use Bisoprolol while waiting for the child tells about the treatment only in the circumstances in which the positive effect of the drug for the expectant mother covers the risk of complications and pathologies of development in embryo.

drug components fall into the placenta and can affect the formation of the mental development of the babyProvoke severe hypoxia, glycemia pregnant woman or fetus.

72 hours before the date of delivery of medical should abandon the use of the drug because of the risk of deceleration pulse and respiratory depression in the child during birth. At impossibility of discontinuation baby is placed in a box for a three-day state control after birth and put on the account in the pediatric neurologist until they reach 1 year.

Young mothers receiving the drug should abandon breastfeeding. The main component of the drug is concentrated in the milk entering the body of the newborn and causing irreversible phenomena in the central nervous system.

How to take with abnormal liver function

not more than 10 mg should be used in chronic liver dysfunction. the drug for 24 hours under strict supervision of a cardiologist. When sudden relapse of disease therapy to interrupt the scheme, gradually reducing the dosage.

If the kidney function

Bisoprolol administered to patients suffering from kidney disease, just in case the flow of the latent pathology for 6 weeks. The maximum amount of drug should not exceed 10 mg. for 24 hours.

Throughout the course bidopa should monitor the state of the kidneys, carried out clinical and diagnostic examination of urine analysis is not less than 1 time a week, especially in elderly patients.

During exacerbation of chronic disease, you need to stop using bisoprolol gradually, according to the scheme of construction of the attending physician. When adrenal cancer drug is prescribed only in combination with alpha-blockers.

In childhood,

Bisoprolol: instructions for use are not allowed to blocker kids under 18 years of age. The main component of the pill is dangerous for young children, can cause serious pathology ZHGT, endocrine, cardiovascular and nervous systems.

In cases where the mother nevrozhdonnogo forced to use the drug - breast feeding should be stopped, and the son or daughter to watch a neurologist and pediatrician.

How long to take bisoprolol

The medicament is designed for long-term use. The course is from 5 to 10 weeks, according to the dosing scheme, certain cardiologist for the particular patient. With a sharp deterioration in health, rejection of the internal organs of components of the drug - use Bisoprolol should be discontinued gradually reducing the amount.

drug interactions

Bisoprolol - instruction manual clearly defines the compatibility of drug pills with other drugs.

It is undesirable to carry out therapy at the same time:

• Antiatsidnymi and antidiarrheal tablets - Absorption is a reduction of beta-andrenoblokatorov.
• Antiaretmichnymi means verapamil Dilteazemom - perhaps a sudden large decrease in blood pressure, heart rate, increased arrhythmia.
• antihypertensive agents - is fraught with strengthening their actions ;.
• cardiac glycosides - there is a risk of vascular permeability disorders;
• Guanfacine, reserpine - a great danger of bradycardia, conduction deterioration.
• Insulin, drugs regulating the level of dextrose in the blood - there is a strengthening of functional activity of the thyroid gland, there is a risk of hypoglycemic coma. Suffering from diabetes, in the treatment bidopom required to control the amount of monosaccharide in the body every day;

• clonidine - provoked by bradycardia, hypotension. Stop taking this drug should be strictly after the abolition of Bisoprolol.
• ergotamine - risk of poor circulation functions.
• Nifedipine, calcium blockers - together have a strong antihypertensive action.

Compatibility bisoprolol and alcohol

Instructions to bisoprolol does not give a clear answer about the drug compatible with alcoholic beverages.

However, having carefully studied the text, we can draw the following conclusions:

1. The medicament has inhibitory effect on the central nervous system, in particular, it is shown when combined with ethanol contained in alcoholic beverages.
2. Slower reaction time, affects the ability to drive a vehicle is not recommended for people whose work function is associated with increased concentration. Alcohol may increase the side effects of this bidopa.

Alcoholic drinks are dangerous for people suffering from hypertension and angina, as:

1. The consumption of alcohol increases the likelihood of a hypertensive crisis, provoked by a sharp narrowing of the blood vessels previously.
2. Alcohol provokes the manifestation of hypotension, increase angina.
3. Toxic to the coronary vessels.
4. Adversely affect drug metabolism, reduces the therapeutic effect of medicines.

Despite the negative effects of alcohol, doctors advise when taking Bisoprolol switch to "prohibition".

It should only take precautions:

• not to drink hard liquor in large quantities;
• limit alcohol intake of 2-3 times per week;
• select only soft drinks, completely eliminate the consumption of beer and its derivatives;
• in alcohol dependence should gradually reduce the dose, leading to 40-50 ml. 1-2 times a week. Sharp rejection of alcohol may lower the blood pressure of 6-9 mmHg n

What can replace bisoprolol analogues

Similar in composition and therapeutic properties of drugs are Russian pharmaceutical companies:

1. Biprol - the cost of up to 350 rubles. Beta blocker type. It reduces the amount of blood in minute reduction of the heart muscle. Has a prolonged effect (after 3-4 tablets). Contraindications to the use are increased sensitivity, heart rhythm disturbances, chronic diseases of internal organs, lung disease.
2. Aritel - complete replacement bisoprolol, the price of 280 rubles. Not allowed in chronic heart disease, arrhythmia, asthma, psoriasis. It has an adverse effect in combination with other drugs or similar properties.
3. amlodipine (280 rubles) - the active ingredient - bazilat amplodipina. Should not be taken with hypotonia, cardiac arrhythmias and heart rate, tachycardia, after suffering heart attacks.
4. Niperten - it has a similar formula with bisoprolol. It is indicated for the problems of the heart. Be used with caution in patients with hypoglycemia.

Belarusian producers are:

1. Bisoprolol - FT (190 rubles) - recommended for ischemia, heart failure, arterial hypotension.
2. Bisoprolol-Mick (120 rubles) - is produced in the form of powder. It is prohibited to use at diseases of the heart.
3. Bisoprolol-Barimed (60 rubles) - is able to provoke a strong allergy to its components.

European analogues of the drug:

1. Lokren (France) - universal medicament for lowering blood pressure. Not addictive even with prolonged use, effective in stressful situations. Contraindicated in faults in the rhythm of the heart. The cost of 1400 rubles.
2. Sandoz (Ukraine) - has many undesirable effects. Price up to 340 rubles.
3. Coronal - 360 rubles. Contraindicated expectant mothers and breastfeeding, in addition, is prohibited in violation of the heart rate and lung diseases.
4. carvedilol - Bisoprolol is different from the composition, but is similar in therapeutic effect. It is used several times a day, has a strong inhibitory effect on the central nervous system cells.
5. Bidop actively used in the medical correction of cardiovascular disease, such as hypertension, coronary heart disease, tachycardia, angina pectoris, myocardial infarction history.

Effectiveness in the treatment of cardiovascular diseases

Active substances have a blocking action of the drug on andrenoretseptory in standard doses virtually provoke side effects. Unlike other drugs, bisoprolol not penalized renal function krovolipidny composition, hydrocarbon metabolism, does not cause bronchospasm, inhibition of respiration, does not change the level of cholesterol.

The drug is effective in nicotine addiction and obesity.

When hypertension:

• normalizes blood pressure, both at rest and during exercise;
• It has no negative effect on sexual function, especially in men;
• rarely provoke hypoglycemia in patients with diabetes;
• indicated for the treatment of young patients who are prone to an active lifestyle;
• completely soluble in fat, lower blood pressure in people suffering from obesity.

In ischemic heart disease:

• eliminates ischemia;
• increases heart rate variability;
• angenoznyh prevents the occurrence of seizures;

The tendency to myocardial infarction:

• reduces the risk;
• It reduces the risk of deaths;
• It is used after surgery in the heart.

Price

The cost of the drug depends on the Pharmacy and the manufacturer. On average, you can buy pills for as low as 34-360 rubles. Foreign counterparts can cost about 500 rubles. It sold only with a prescription from a doctor.

Storage conditions

The drug of the category B. Keep it in a dry, the reach of sunlight, at a temperature of 24-26 degrees. It is particularly important to exclude children's access to the tablets. Shelf life up to 36 months inclusive.

High blood pressure, heart disease, caused by the strong reaction vessels receptors on the adrenaline rush - problem prevents many people live. The use of bisoprolol, according to the instructions helps to lower the risk of developing the disease and its complications, the most correct course of disease and allow to enjoy life in any age.

Video of bisoprolol, the rules of its application and analogues

Bisoprolol for treatment of hypertension:

Application Concor Bisoprolol and for the treatment of heart disease: