DENEBOL is a medicinal product that has anti-inflammatory, antipyretic and analgesic effects.
The drug is classified as a class of non-steroidal anti-inflammatory drugs. The drug is recommended for use in pain, inflammatory reactions and edema of joints.
One of the forms of release of Denebol - tablets( 25 and 50 mg, 10 tablets in a blister pack), the other is a solution for injections( ampoules of 5 pieces per pack, 1 ml).
The market also offers a tube shape with a gel of 30 g and candles for rectal use.
The content of the article
- The pharmacological action of
- The pharmacokinetics of
- What is the composition of
- The effect of the drug on the body
- When the drug is used
- Contraindications to the use of
- The dosages and the way of application of the preparation
- The use of injections
- The dosage of the drug in tablets
- External use
- Rectal candles
- Cases of overdose
- Side effects of
- You need to know!
- Interaction with other medications
- Receiving funds for pregnancy and lactation
- Read on
- forums The choice is yours
- Purchase and storage of medication
- If there is no drug at the pharmacy
Pharmacological action
Two enzymes - cyclooxygenase I and cyclooxygenase II - are actively involved in the development of inflammatoryreactions in the human body, as they contribute to the formation of inflammatory mediators: prostacyclin, prostaglandins and thromboxane.
COX II does not always participate in reactions, which allows it to selectively block it without harm to the body.
It is on COX II that the action of Denebol is directed, which allows not to disrupt the work of COX I, which performs important functions in a normally functioning organism.
Pharmacokinetics of
Denebol refers to drugs with high digestibility.
Dinebol bioavailability is more than 90%.At the end of two hours after the intake, the concentration of the drug in the blood reaches its peak - an increase in the threshold of the active substance rofecoxib to 0.300 μg / ml is noted.
The drug binds to blood plasma proteins, but this connection is unstable, about 80% of the drug enters it. Biotransformation of the drug occurs in the liver.
Biotransformation results in six inactive metabolites, 70% of which are excreted through the kidneys with urine.
Rofecoxib, an active substance in a medicine, can leave the body in its original form through fecal masses. There was no difference in pharmacokinetics in young people and elderly patients.
What is included in
Rofecoxib is the main active substance of Denebol. 
In addition to it, the formulation includes:
- methyl salicylate, which has anti-inflammatory and analgesic effect;
- linseed oil;
- phenoxyethanol;
- menthol.
The effect of the drug on the body
The mechanism of action of Denebol is similar to the mechanisms of other non-steroidal anti-inflammatory drugs.
The drug inhibits the enzyme cyclooxygenase II.
Since COX II is responsible for the production of prostaglandins, the main mediators of inflammation, in the absence of this enzyme or in its absence, prostaglandins are not formed and, as a consequence, the inflammation goes on decline, there is a noticeable regression.
Because the drug depresses COX II selectively, it turns out that its main effect is directed precisely to the focus of inflammation.
When is the drug used
Indications for use:
- osteoarthritis is a disease characterized by affection of the cartilaginous tissue of the joints;
- arthritis rheumatoid and a number of other diseases, the main manifestation of which is the defeat of small joints and connective tissue defects;
- periarthritis is an inflammatory process in the periarticular tissue;
- tendonitis is an inflammatory process in the tendon tissue;
- bursitis - inflammatory process in the periarticular bag;
- Thrombophlebitis is an inflammatory process in the vein wall that develops due to thrombus formation;
- painful sensations of unknown origin ;
- injury ;
- stomatitis - inflammation in the mucosa of the oral cavity, as well as pulpitis - inflammation of the pulp and gingivitis - inflammation of the gums;
- inflammation of various genesis in the genitourinary system ;
- inflammation of the ENT organs of , broncho-pulmonary system and eyes.
Contraindications to admission
To apply medicine Denebol should not be used in such cases:
- an anamnesis is known that reports an allergy to aspirin or other NSAIDs;
- bronchial asthma( can cause bronchospasm - "aspirin asthma");
- disease of oncological nature;
- for children under 12 without doctor's supervision;
- heart attacks, strokes, atherosclerosis - a contraindication for the use of the drug intramuscularly;
- pregnancy and lactation;
- people over 65 years.
Dosages and method of application of
Depending on the form of release, Denebol is applied according to the instructions below.
Injections
Intramuscular injections are done once every 24 hours in the buttock. Usually a short weekly course is prescribed, and then a transition to a tablet or gel occurs.
The total dose for different routes of ingestion should be no more than 50 mg.
Dosage medications in tablets
Denebol tablets for pain and primary dysmenorrhea are recommended at a dose of 25 mg.
The next dose is allowed only after 24 hours, since the dose of the medicine entering the body per day should not be more than 25 mg.
Treatment lasts three days. Tablets are consumed regardless of food intake, washed down with water.
Osteoarthritis requires the use of the drug at a dosage of 12.5 mg, and if no effect is observed, then a dose increase of up to 25 mg is necessary.
The recommended use time is 4-6 weeks.
External use of
Gel-Denebol is used topically 4 times a day.
A quantity of gel, comparable in size to a pea, is applied to the skin.
The drug should not come in contact with mucous membranes and open wounds.
Treatment continues until effect is achieved.
Candles rectal
Candles are used rectally and are intended for relief of acute inflammatory processes or dysmenorrhea.
Use 1 suppository 2 times a day. The maximum daily dose of 50 mg.1,5 months - the maximum duration.
Cases of overdose
Clinical studies have not revealed high drug toxicity.
The drug was used by control groups at dosages of 1000 mg per day at a single point and 250 mg per day for two weeks, but no toxic effects were noted.
However, if the recommended daily dosage is prescribed, gastric lavage and maintenance therapy are prescribed.
Side effects of
Such adverse reactions of the body can be observed:
- Reactions of the nervous system are characterized by drowsiness, dizziness, headaches, decreased reaction speed, slowing down of thought processes and hallucinations.
- The cardiovascular system reacts with the development of congestive heart failure, arterial hypertension, and coronary circulation disorders.
- The side effect on the digestive tract has been expressed: dyspepsia, nausea, vomiting, heartburn, epigastric pain syndrome, aphthous stomatitis.
- One of the most dangerous side effects is the action on the urinary system .Possible development of renal failure, which will begin with a decrease in the rate of glomerular filtration.
- Allergic reactions .
- Increase in ALT and AST, swelling of .
You need to know!
Because of the slow reaction and inhibition, developing due to the drug, it is necessary to temporarily stop driving vehicles.
Do not use the medicine with alcohol! There were no cases of a decrease in liver function on the background of medication.
It is possible to develop renal failure, but at the same time the drug with the already existing deficiency is used with caution.
Interaction with other drugs
Medication:
- decreases the effectiveness of ACE inhibitors, which negatively affects antihypertensive therapy;
- should not be taken with products that have caffeine, it is not recommended, as this causes a blood pressure jump;
- shows an increase in prothrombin time if the drug is used together with anticoagulants;
- combined use with a part of antibiotics reduces the concentration of the drug in the blood by 50%;
- pharmacokinetics of prednisolone, oral contraceptives, cimetidine, digoxin, antacids does not change on the background of taking Denebol.
Receiving funds for pregnancy and lactation
For I-II trimester, the drug is used with caution, with the expectation that the benefit to the mother exceeds the risks to the fetus.
In the third trimester, the use of the medicine is prohibited.
For lactation, use is prohibited, as the drug penetrates into breast milk.
The drug is contraindicated in children under 12 years old.
Read on the
forums Reviews of people who take Denebol were collected at specialized forums.
I was prescribed a medicine after the diagnosis of "stretching".I used the gel for 4 days, everything took off like a hand.
Alina
Being on a visit in another city, she was bent over from severe abdominal pain due to PMS.The drugstore was advised by Denebol. After taking the pill within 10 minutes, the pain is gone. The effect lasted quite a long time.
Vitalina
Her husband has developed a sciatica. The doctor advised the injection of the medicine. Literally after the first husband began to get up again. And the third could already and skip. But! The introduction of the drug is very painful!
Karina
I do not recommend using anti-inflammatory drug Denebol gel for the treatment of joints and back. After applying the gel, you instantly forget about the pain due to a terrible burning sensation, but it soon returns. Absolutely ineffective tool!
Serega
I often appoint Denebol in pain syndromes of unclear etiology. The drug acts quickly and effectively relieves pain.
Practitioner
The choice is yours
Thus, the drug has such pros and cons:
- effectively relieves pain;
- quickly removes inflammation when taken locally or systemically;
- is easily tolerated by patients;
- effect occurs relatively quickly;
- but at the same time, the injections are very painful;
- gel may cause burning.
Purchase and storage of medication
The drug is available without a prescription.
Average price of money Denebol:
- gel( tuba, 30g) - 100-120 rubles;
- in ampoules( 25 mg, 5 ampoules) - 160-170 rubles;
- tablets( 25 mg, 10 pcs.) - 180-190 rubles;
- Tablets( 50 mg, 10 pcs.) - 270-390 rubles.
Store the drug at room temperature from +15 to +25.You need a dry, dark place.
Gel Denebol is not subject to freezing! Shelf life - 2 years.
If there is no remedy in the pharmacy
Denebol analogues are:
- Diclofenac;
- Indomethacin;
- Voltaren;
- Zeel T;
- Ultraflex;
- Ketonal;
- Ibuprofen;
- Artrum gel.
When selecting analogues, the emphasis was placed on a similar mechanism of action and indications for use. Similar drugs are much more, mentioned only those of them that are on hearing and are prevalent.
