Rosuvastatin. Instructions for use. Price, reviews, analogues

Rosuvastatin has a sufficiently detailed instructions for use with a detailed description of the indications and contraindications. The drug belongs to one of the most studied statin agents. This lipid-lowering medication is indicated for reducing the level of "bad" cholesterol.

At the same time it increases the "good" cholesterol in the blood plasma. Is a fourth-generation drug, it is actively recommended by doctors for the purpose of preventing atherosclerosis and remedy its consequences.

Clinico-pharmacological group

Rosuvastatin - 4 hypolipidemic drug generation, is a group of statins. Drug development is owned Japanese digging for the production of pharmaceuticals. The drugstore chain sold since 2003 by prescription only released in Russia. In the ranking of the number of receiving angry patients, facility occupies a leading position.

Active ingredients Rosuvastatin contribute to the oppression of the enzymes that cause the formation of new cholesterol in the liver. The result of the drug is to restore the damaged blood vessels and improving the rheological characteristics.

Stoped by negative developments of thrombus, improves blood viscosity. Positive impact on the patient's body from the regular use of the drug is already apparent after 30 days of therapy. Self statins unacceptable due to high toxicity drugs receiving components.

Composition, structure and packing

Preparation Rosuvastatin is produced in batches of 10, 14, 28, 30 and 90 units. In each of them are contoured cell with tablets. Some manufacturers offer the drug in polymer tubes of 20, 40 or 90 pieces. Dosage: 5 mg, 10 mg, 20 mg and 40 mg. The tablets covered with a cover of pink color in a cut - white. One tablet contains 5, 10, 20 and 40 mg Rosuvastatin respectively.

Additional components 5 mg tablets include:

• aerosil;
• pregelatinized starch;
• Medical microcrystalline cellulose;
• magnesium stearate.

The composition of the drug is increased in accordance with the dosage of each tablet.

The shell contains Opadry Pink 3, 20 mg, which includes:

• triacetin;
• carmine red dye;
• Valium;
• lactose monohydrate.

pharmachologic effect

Rosuvastatin is part of a group of drugs that inhibit HMG - CoA - reductase, which plays a major role in the processing of cholesterol. Drug molecule is designed so that it is not exposed to rapid dissolution in fats, thus impacting on the body like natural enzymes.

As a result of rosuvastatin connection with the desired acceptor is an irreversible process and instantaneous. Because of this synthesis in the liver tissues of mevalonic acid is reduced by several times, which inhibits the development of "bad" cholesterol. Marked activation of receptors for cholesterol fractions, resulting in better plaque affected are removed from the blood.

After the drug was received into the body, it contains the highest concentration by 5-5.5 hours. With regular therapy develops equilibrium concentration, and its maximum occurs through 4:00. active substances clearance rate from the body is not in direct proportion and up to 20 hours.

The active ingredients of a medicament promote stimulation of synthesis of nitrogen, which is involved in vascular relaxation processes. This creates a pleiotropic, ie an additional effect. As a result, relief of chronic inflammation sluggish nature, being the main cause of arteriosclerosis.

Product reduces LDL-cholesterol (LDL-C), total cholesterol (TC), triglycerides (TG), enhances lipoprotein-cholesterol high density (HDL-C), reduces the content of apolipoprotein B (apoB), VLDL-cholesterol, VLDL-TG and activates the concentration of apolipoprotein A-I (ApoA-I).

Therapeutic result begins to appear already a few days after a dose. The maximum effect is observed on the fourth week of treatment, and if you continue taking the medication, it is maintained at the same level.

Pharmacokinetics

• Absorption and Distribution. The highest content of active substance in the blood observed after 5 hours after use. Complete bioavailability equals of 20%. More than 90% of the drug absorbed blood proteins.
• Metabolism. Metabolized by only 10%.
• Withdrawal. On the display memory 10%, 90% unchanged means output through the esophagus.

Pharmacokinetics in specific patient groups:

• Age and sex characteristics of patients are not important for optimal preparation of assimilation.
• The representatives of the Mongoloid race suffering from a 2-fold increase in blood money. Therefore, therapy is contraindicated for them.
• Genetic polymorphism. Carriers genotypes marked increase in active substance concentration of rosuvastatin 2.4 times.

testimony

Rosuvastatin (instruction manual contains instructions on dosage and general scheme of the use of the drug, taking into account individual characteristics of the patient) is recommended for the treatment of pathological processes that encourage the accumulation of cholesterol and its fractions body.

Use of the drug:

• Hereditary nature of the disease, characterized by impaired cholesterol metabolism in the diagnosis of primary hypercholesterolemia. Abnormal accumulation of cholesterol fractions has a genetic basis. When the diet, increased physical activity in these situations do not have a positive outcome.
• Progressing stage of atherosclerosis. Statin therapy is shown, as an additional method to comply with the diet.
• Prevention of disorders of the heart and blood vessels in people with no symptoms of ischemia. Age limit: men over 50, women over 60 years.

Predisposing factors for the use of rosuvastatin recommendations:

• hypertension;
• lower cholesterol;
• hereditary risk for early ischemia;
• lack of exercise;
• smoking;
• obesity;
• diabetes.

Small dosages of drugs contribute to the improvement of the lipid balance.

The main purpose of rosuvastatin:

• reduce the risk of stroke;
• prevent the development of myocardial infarction;
• reduce the amount of arterial revascularization procedures.

Rosuvastatin individually prescribe and patients with cholesterol levels does not exceed the norm.

This group includes patients:

• After giving a stroke or myocardial infarction;
• with a diagnosis of ischemic heart disease;
• for rehabilitation after surgery on the coronary arteries;
• diagnosed with diabetes with rates significantly higher than normal LDL.

Contraindications

Especially drug in that it has a dose-related side effects and contraindications. If the patient is shown to take 10 mg of drug, it does not mean that ever need to increase the dosage to 20 mg.

Receiving above 5 mg prohibited for patients suffering:

• active inflammatory processes in the liver (hepatitis, cholangitis);
• complex-stage renal failure;
• illness myopathy.

And also contraindicated drink tablets in combination with the use of cyclosporin, pregnancy and breastfeeding. The ban applies to children under 18 years of age.

In addition to these contraindications to use of 40 mg of rosuvastatin is prohibited:

• when combined treatment with fibrates;
• patients with alcohol dependence;
• muscular pathologies when diagnosed;
• hypothyroidism.

Absolute contraindications relates allergic reaction to components of the synthetic drug.

Dosage instructions for use

Rosuvastatin preparation instructions for use, which indicated that the use of tablets possible before meals, during or after meals. A necessary condition for the simultaneous treatment of statin adherence to a strict diet. This is required in order to avoid getting cholesterol from food.

The drug is available in Tableting dosage form of 10, 20 and 40 mg.

Each patient is assigned to the amount of drug individually. At dosage affects the concentration of lipids in the blood with detailed figures. In the first stage of treatment the patient is discharged by means of 10 mg. If the patient does not suffer the high risk group of obesity and infarct low dose is reduced to 5 mg. Increasing the tablet is allowed only after 30 days.

Dosage of 40 mg administered when indicated:

• high risk of heart attack and stroke;
• severe hereditary hypercholesterolemia.

In 14-30 days of taking the maximum dosage required to conduct control studies lipid levels. Given the clinical and biochemical results of the attending physician decides the tactics of therapy. Strongly contraindicated start immediately the first use of statins with high dosage (40 mg).

Side effects

Proper implementation of recommendations of the doctor, the principle of gradualness in taking medication side effects occur very rarely.

In exceptional cases, may develop:

• headaches;
• rashes on the skin;
• increase in muscle tone;
• muscle aches.

In some patients, one side effect is an increase in transaminase levels in the blood. In case of complaints of the patient at a constant discomfort in the muscles and the presence of pain is necessary to pass a special examination to exclude the development of rhabdomyolysis (muscle disintegration).

Overdose

Rosuvastatin, instructions for use which requires the principle of gradually increasing dosage, with caution needs to be drunk in patients with liver disease. Abuse of appointments and an increase in single dose a few times does not alter the pharmacokinetic properties. Special treat overdose of medication does not exist.

Therapy is based on the clinical picture, and all therapeutic methods aimed at arresting the negative manifestations. The patient is assigned to study the liver and creatine phosphokinase levels.

The clinical picture of overdose manifest similar side effects. Rosuvastatin uniqueness that it is metabolized in the liver by only 5%. Almost 90% of the output in its original form through the digestive tract.

drug interactions

The patient is mandatory to warn doctors about all medications taken. Even the periodic use of certain drugs in combination with rosuvastatin is dangerous for health.

• Cyclosporine. Rosuvastatin content increases several times. Medications are incompatible.
• Inhibitors of protein synthesis. Combination preparations provokes growth rosuvastatin concentrations resulting in, its content will be increased and develops myopathy.
• Lipid-lowering drugs. Contribute to an increase in plasma means 200% of normal. Perhaps the reaction at the lowest dose used primary means is 5 mg. The maximum dosage is dangerous for the patient.
• Ezetimibe. Perhaps the development of some of the negative state. The joint application is not assigned.
• Antitsidy. Combined therapy is possible, if to take breaks honey receiving means with a difference of 2 hours.
• Erythromycin. The combination reduces the concentration of active substances rosuvastatin due to increased activity of the bowel.
• Oral contraceptives. When combined deterioration of health and adverse effects have been identified. The preparations are well tolerated by patients.
• Immunosuppressants. Combined therapy is often the cause of renal disorders and rhabdomyolysis.
• anticoagulants combined with rosuvastatin may provoke the formation of internal bleeding.
• Antifungal agents. The result of the interaction is renal dysfunction.

Self rosuvastatin unacceptable due to poor interaction with most synthetic drugs. Its reception is bad for the glucose assimilation.

When the complex treatment is necessary to monitor the plasma cholesterol and lipids. The attending physician after diagnosis is complete optimal treatment regimen for each patient individually.

special instructions

Rosuvastatin (instructions for use and special individual orders are required to study for patients using the drug for a long time) should not take longer than a week without medical recommendations. If you feel unwell, combined with muscle spasms or pain and fever is required to immediately contact the medical facility.

It is identified creatine phosphokinase levels. If its performance exceeds the norm by more than 5 times the treatment should be stopped. Under constant clinical observation should be patients during acute inflammation of the urinary tract and kidney, with the possibility of myopathy, myalgia.

Determining the level of lipid metabolism during treatment should be carried out for 2-4 weeks. There have been cases of interstitial lung disease character. The patient develops shortness of breath, a cough. The doctor should stop taking statins, even if there are problems with the lungs of patients are diagnosing stage.

Pregnancy and lactation

Rosuvastatin is contraindicated use in the treatment during pregnancy and breastfeeding. You can not drink the medicine when planning pregnancy. Its negative impact is especially dangerous in the first weeks of gestation.

Cholesterol biosynthesis and its products are essential substances for the full formation of the fetus. Possible risks of inhibition of reductase several times the beneficial effects of the drug during pregnancy.

The use in children

Children under 18 years of age, drug treatment is not administered.

When renal impairment

Renal failure is an indication for the reception of rosuvastatin careful dose is 5. 10 or 20 mg. The use of pellets of 40 mg in exceptional cases, when a low degree of renal failure. For moderate and severe renal impairment drinking drug forbidden.

With moderate renal pathologies reception permitted minimum dosage of 5 mg.

In human liver

If you have liver disease the use of any medication dosages permitted in the patient history. The exceptions are acute diseases and a significant increase in serum transaminases. Before treatment, the patient must undergo an examination to determine the indicators of liver function.

In a similar manner to trace the dynamics of the required 90 days after the first dose tablets. If serum transaminase increase in 3 and more times than required by the standards, taking rosuvastatin overturned.

Use in the elderly

Rosuvastatin (instructions for use, and the recommendations of the doctors on this show) for elderly persons appointed in the usual way.

Terms of sale and storage

The drug falls in pharmacies only by prescription. Store Rosuvastatin must be protected from sunlight, out of reach of children. Storage Temperature - not exceeding 25 degrees. Shelf life is indicated on the packaging, and should not exceed 2 years from the date of production.

drug analogues

Among the analogues of the drug release:

Name	pre-packing	Price
Crestor	28 pieces of 5 mg	1300 rub.
Canon	Pieces 28 to 10 mg	355 rubles.
Roxer	30 pieces of 5 mg	383 rubles.
Merten	30 pieces of 5 mg	478 rubles.
Rozulip	28 pieces of 5 mg	469 rubles.

Preparations have identical effects on the drug composition. From the distinctive features can distinguish different material content casing which is covered by the main component rosuvastatin calcium. Manufacturers offer a wide range of quantitative composition and the form of packages of synthetic drugs based on rosuvastatin.

Rosuvastatin cost in pharmacies of Moscow, St. Petersburg, regions

Moscow 30 tablets of 5 mg of rosuvastatin may be purchased from 510 rubles. The minimum price for the same pack, but 10 mg ranges from 549 rubles. The dosage of 20 mg should not less than 876 rubles.

Pharmacies St Petersburg Rosuvastatin packing at 30 tablets at a dose of 20 mg (manufactured by Vertex) can be bought for 490 rubles. A similar pack of 90 tablets will cost 979.40 rubles. Manufacturer Izvorina Pharma offers a package with 30 tablets of 40 mg of 1634.20 rubles.

In Krasnodar, a pack of the drug (30 pcs.) Dose of 20 mg will have to pay 394 rubles. In Barnaul, the same packaging is not less than 395 rubles and 384 rubles in Ingushetia.

Rosuvastatin requires compliance with the principle of gradually increasing dosage, as indicated in the instructions for use. Therapy is contraindicated start immediately with the maximum receiving tablets of 40 mg. With the development of muscle cramps, headaches, fever is required to immediately stop taking the drug and consult a medical facility.

Helpful videos about the drug Rosuvastatin and its effectiveness

Detailed description of the preparation:

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