People with severe pain on a background of inflammation, injury or after surgery, often prescribed analgesic non-steroidal anti-inflammatory drugs (NSAIDs). It is to this group includes Nimesil and Ketanov. But it is better Ketanov or Nimesil? This issue is of concern to many, the first time faced with this group of drugs. In addition, often ceases edge of the compatibility of drugs with each other.
The composition and characteristics of action of drugs
If the active substance acts nimesil nimesulide, ketorolac then (ketorol) underlies Ketanova.
Ketanov The drug is available in two pharmaceutical forms:
- injection vials (containing 30 mg ketorol);
- Tablets for oral administration (comprising 10 mg of ketorolac tromethamine).
As to nimesil, it is available in the form of bags with a powder (100 mg of nimesulide) for the preparation of the drug suspension.
Both drugs are aimed at blocking the synthesis of prostaglandins have both anti-inflammatory and analgesic effect. However Ketanova analgiziruyuschie properties predominate over anti-inflammatory action. In addition, the maximum concentration of the active substance Ketanova observed already after 45 min., While in Nimes, this figure more than 2-3 times.
But if we compare the effect of drugs, then Ketanova it is only 4-6 hours, while nimesil - 6-12 hours. Also, there are some differences in the metabolism of drugs and withdrawal. Thus, the main route of metabolism Ketanova - binding glyukuronnovoy acid, after which 10% of the active substance is exported from faeces, and 90% of kidney (2/3 being unchanged). Nimesil same output half kidneys, and the second portion leaves the body in the bile.
testimony
Take Ketanov and Nimesil recommended in such cases:
- severe pain of various localization (dental, gynecological, urological, orthopedic);
- acute pain due to muscle injuries and bone;
- postoperative pain;
- renal and hepatic colic;
- cancer pain.
However, it should be emphasized that in all these pathological conditions take Ketanov can be no more than 2 days. As far as Nimes, its maximum application - is 14 days, with a possible extension of this period, on doctor's advice. Therefore Nimesil more effective in the case of long-term therapy.
pharmacokinetic interaction
Often, the combination therapy of a pathological condition, acute is the question of the compatibility of preparative. Immediately it is worth noting that Ketanov need to be prescribed with care to persons receiving high doses of salicylates. Also, this drug will reduce the effectiveness of warfarin. With regard nimesil need to remember the following: preparation, while the use of anticoagulants and corticosteroids may provoke bleeding, in addition, the drug reduces the effect of diuretics and remedies for elevated pressures.
Moreover, people are often interested in: whether it is possible to combine the preparations based on nimesulide (Nimesil, Nise) or their nurofny analogue of ibuprofen with antibiotics and what Ketanova compatibility Nimesilom. Of course, optimally when all the drugs are prescribed by the attending physician that eliminate the possibility of a fatal error.
But in circumstances where there is no possibility of recourse to a specialist, it is important to remember that although NSAIDs perfectly combined with antibiotics and helps to cope with complex illnesses, but they are not always interconnected compatible. Resist the temptation, trying to enhance the action of one drug by another, and drink at the same time Nimesil Ketanovom.
sources:
Vidal: https://www.vidal.ru/drugs/nimesil
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = feea99ed-6bbf-4079-920f-ad79aeed5c36 & t =
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