In the treatment of yeast and fungal diseases of the skin and nails it is important to understand how to take Fluconazole, before meals or after. In the instructions for use indicated that the medication is not dependent on food intake, but He wants to choose a way reception, preventing the harmful effects of drugs on the digestive system and does not reduce the efficacy of antifungal the drug.
Below we consider the main characteristics of fluconazole, as well as the features of his actions in different situations while taking before eating and after.
Release form of the drug
Preparations based on fluconazole intended for domestic use are available in the form of four oral dosage forms that include:
- pills;
- capsules;
- syrup;
- soluble (dispersible) tablets.
They are intended to produce systemic antifungal activity, but the latter form can also be used topically - after the preparation of the solution.
In most cases, the drug is used in a single dose of 150 mg, which needs to be drunk once a day. The medicine is washed down with water in a small volume.
As eating may affect the absorption and excretion of Fluconazole
If the statement does not give clear guidance on the time of dosing in relation to meals, the need to understand features the absorption, distribution and excretion of the drug, so that you can figure out how to take it, before eating or after. Fluconazole is used for a long time and his path in the body has been well studied.
The active ingredient is rapidly absorbed in the digestive canal, regardless of the presence of food. The drug is very soluble in water and readily penetrates the blood is drawn about 90% of the dose. Passes through the liver, the entire amount of the active substance sucked out of the stomach and intestines.
Since the bloodstream Fluconazole spreads throughout the body, well permeating all liquid tissue and secrets: the saliva, sputum, cerebrospinal fluid, mucus. The highest concentration in the blood is recorded after 1-2 hours after the internal use of the medicament.
Most of the dose absorbed into the bloodstream Fluconazole is displayed through the urinary organs neizmenennnom state - up to 4/5 of the total. A small percentage excreted in the urine as active metabolites. To 5-10% of the drug accumulates in the outer cover and excreted from the glands secret.
Eating before or after a meal does not affect the absorption of drugs completeness, but the scope and nature of the ingested food can affect the speed of dissolution of a tablet or capsule, the rate of absorption into the blood and excretion speed of active component. The speed of passage of the drug into the bloodstream also depends on the dosage form employed, the rate of absorption of the active substance with the above using a syrup or solution, as for the complete dissolution of capsules and tablets need additional time to an average of 10 minutes.
At the use of large amounts of water and liquid food volume of the circulating fluid is increasing rapidly and accelerate its excretion by the kidneys. In this case, the excretion of Fluconazole is accelerating.
When important links taking the medicine with food
If the fungus strikes the wall of the mouth, pharynx, or esophagus, and there is a need and possibility of local impact - the need to take Fluconazole after eating, using for the treatment of syrup or dissolved dispersible pills. Medicine drink slowly, in small sips, they can rinse the affected area. When candidiasis of mouth before swallowing medication better hold in the mouth 2 to 3 minutes before swallowing. After that, you do not need to eat or drink for 1-2 hours.
After the meal, you need to take the medicine and for patients who develop adverse effects from stomach, intestine and liver, such as nausea, diarrhea, pain, and improvement of enzymes in blood.
Before a meal you should drink the drug Fluconazole in most other cases of its application because the fasting provides rapid absorption drug and redistribution in the body prior to excretion intensive, which increases with increasing revenue with food and water drinks.
conclusion
Fluconazole - effective antifungal medicament Conveniently dosage regimen which can be drunk before or after a meal. Fluconazole penetrates well into the blood, regardless of the connection with the food, but the use of different forms of release of better communicating with a meal and depending on the form of disease and adverse effects the drug.
In most cases it is best to drink before meals FluconazoleAnd in the treatment of lesions of the upper digestive apparatus will be optimal use of liquid forms of medication after a meal or a few hours before a meal.
sources:
Vidal: https://www.vidal.ru/drugs/fluconazole__12803
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = a35154cb-6bbe-4dc2-b8a1-c478d7407760 & t =
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