Say for sure which is better - Fluconazole or Terzhinan extremely difficult, because it depends on the clinical case. Sometimes it is enough and only means of local action - a combination of antifungal, antibacterial and anti-inflammatory components in Terzhinane copes well with bacterial and fungal vaginal lesions and without systemic therapy. However, there are situations where a topical treatment is not sufficient and it is necessary to use means for systemic effects, such as fluconazole.
Features of the pharmacological action of Fluconazole
The active drug substance inhibits the livelihoods of not only the fungi of the genus Candida, but also in other mycoses caused by pathogenic and opportunistic fungi. Fluconazole inhibits the activity of members of the cytochrome P450 enzymes, resulting in broken ergosterol synthesis processes (membrane lipid), which leads to an increase in cellular permeability membrane. Fluconazole is highly selective when it means, and has virtually no effect on the activity of these enzymes in humans.
This drug can be administered at:
- Fluconazole can be used for generalized candidiasis lesions;
- Cryptococcal infections of different localization in patients with both impaired and normal immune response;
- Fluconazole is administered in order to prevent fungal infections in cancer patients undergoing a course of radiation and / or chemotherapy;
- Skin diseases, fungal origin, as well as endemic mycoses.
Use Terzhinan concurrently with fluconazole may be, it is quite an effective combination, as antifungal components have different mechanisms of action in the fungal cells.
Pharmacological action Terzhinan
Terzhinan a combined preparation, which comprises the antibacterial (including effective against Trichomonas component), antifungal and antiinflammatory agents. Main Terzhinan antifungal component - nystatin capable embedded in the cell membrane of the fungus, while this by disrupting the processes of water and electrolyte transport across it, which ultimately leads to death cells.
Terzhinan shown in the following situations:
- When bacterial vaginitis, including those caused by pyogenic bacteria, and chlamydia or mixed flora;
- Terzhinan used for vaginitis caused by fungi of the genus Candida (against other fungi means ineffective);
- As a preventive measure Terzhinan can be assigned to the gynecological surgical interventions, as well as before the birth, abortion or intrauterine device installation;
- It can be used to some studies (for example, before hysterography).
If you compare the products, we can see that part of the Terzhinan Nystatin is effective mainly against fungi of the genus Candida, in relation to other pathogenic fungi where its effect is less pronounced, whereas Fluconazole is effective against many pathogens mycoses. However Fluconazole inhibits the ability to live solely fungi, while Terzhinan works against bacterial diseases, Including those caused by chlamydia.
The ability to combine drugs in combined treatment
Take Fluconazole with Terzhinanom makes sense in the case of resistant fungal monotherapy disease, or in the situations where there are not only a fungal infection of the vagina, but also other authorities. It is also not necessarily the use of these drugs, the market is full analogues like the Tata or Flyukos Polizhinaks.
sources:
Vidal: https://www.vidal.ru/drugs/vero-fluconazole__10369
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = a35154cb-6bbe-4dc2-b8a1-c478d7407760 & t =
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