The pharmacological action of the drug
Dexamethasone is a glucocorticosteroid hormone that affects the body's metabolic processes, electrolyte balance and working on some of the functions of the endocrine system. The drug is on the list of essential drugs, because it can help in life-threatening situations.
Dexamethasone during pregnancy is used for the treatment of severe pathologies, localized in different systems of the human body. And as for the treatment of hormonal abnormalities in women, causing the impossibility of carrying a child.
application
Dexamethasone during pregnancy may only be used after appropriate research and consultation with a doctor, for the treatment of the following pathologies:
- endocrine diseases (hyperandrogenism, pituitary insufficiency, rheumatic disorders);
- diseases of the connective tissue and skin (vasculitis, systemic lupus erythematosus, polymyositis, and others);
- visual system disease (endocrine ostalmopatii type and psivdoopuholi);
- diseases of the digestive system
- (Severe ulcerative colitis, hepatitis, transplantation rejection);
- diseases of the hematopoietic system;
- urinary tract disease (glumeronefrity, granulomatosis and others);
- respiratory diseases (bronchial asthma, obstructive bronchitis, laryngitis in severe);
- malignant neoplasms.
Dexamethasone doctors prescribe to pregnant women at a serious need. Most often, a drug used to keep the pregnancy with hyperandrogenism - disorders caused by elevated levels of the male hormone. Such pathology can cause fetal rejection and spontaneous abortion.
The use of dexamethasone reduces the production of testosterone, reducing the risk of miscarriage.
Another pathology that may require the use of dexamethasone during pregnancy - the probability of birth of the baby early. Respiratory system, or rather the baby's lungs are not yet formed, which can be a threat to his life at an early birth. Dexamethasone accelerate lung development, and reduce the risk of birth of an unhealthy child.
In the presence of adrenal hyperplasia Deksametozon pregnant patient is administered throughout the period of gestation. This is a necessary therapy, supporting the health of the expectant mother and reducing the risk of abnormalities at the time of delivery.
Contraindications
Of course, during pregnancy need to take Dexamethasone under the strict supervision of a doctor, and in the absence of the following contraindications:
- Individual intolerance or hypersensitivity to substances forming part of Dexamethasone;
- digestive system diseases (in particular any type gastritis);
- bacterial, viral and fungal infections;
- Functional activity of the kidney and liver;
- thyroid disease;
- diseases of the cardiovascular system;
- acute psychiatric disorders;
- osteoporotic and poliomelitnye pathology.
In the presence of the above diseases the drug is banned for use during pregnancy.
At the present time there is insufficient information about the conduct of clinical trials on the safety of dexamethasone during pregnancy. However, numerous studies of the drug on laboratory animals have reported a negative impact on in-tube development of the fetus.
It is believed that newborn infants may experience severe disease and adrenal insufficiency functions. In this connection, it is recommended to carry out regular inspection of a child whose mother during pregnancy taking Dexamethasone.
If the use during pregnancy and lactation Dexamethasone is necessary, it is recommended to interrupt breast feeding for a period of therapy.
Side effects
Carrying dexamethasone during pregnancy, despite its powerful positive exposure and tolerability, there may be negative features of the various systems body.
These symptoms may appear as follows:
- feeling of nausea, retching, ulcerative lesions of the gastrointestinal tract, increased liver enzymes;
- disorders of the adrenal activity; weight gain, menstrual irregularities, violation of a child;
- disorders of heart rhythm, high blood pressure in the arteries, clotting blood vessels, the development of cardiac insufficiency;
- feeling dizzy, increasing the pressure inside the skull, mental disorders, sleep disorders, headaches;
- visual function disorders, corneal pathology;
- metabolic disorders;
- slowing the regeneration of tissues, and the appearance of acne scars.
Side effects of dexamethasone during pregnancy occur in very rare cases. However, doctors prescribe the drug only in extreme situations, when its use will effect greater than the potential risk to the child's health.
You need to know that the development of adverse side effects is necessary to interrupt the course Deksametozonom treatment and consult a doctor.
planning for pregnancy
Quite often, a woman can not get pregnant. One of the causes of such pathologies may be an increased amount of male hormones in the female body. To clarify the situation, held a special analysis, which determines the level 17 of certain hormones in the blood of the patient. If the concentration is increased, the doctor recommends the use of dexamethasone and prescribe appropriate therapy.
In this case, the drug will help build hormones: restore hormonal balance, reducing production male hormones and normalizes the production of hormones produced by the adrenal cortex and in the end lead to normal pregnancy.
Such therapy is necessary because an increased amount of male hormones in a woman's body (Hyperandrogenism), entails the inability to bear a child, since there is a constant threat miscarriage.
Women planning a pregnancy should be aware that during therapy glyukortikosteroidnymi drugs, in particular dexamethasone may increase body weight.
Since the agent has the immunosuppressive effects - can decrease immune system function and the need to monitor their health, not to catch cold.
But the main, Dexamethasone for planning pregnancy can be administered only by a specialist. In no case be self-medicate and take the medication without consulting your doctor as the use of self-medication can cause irreparable damage to patient health.
drug interactions
Patients need to know what drugs are not recommended the simultaneous use of dexamethasone during pregnancy:
- Simultaneous use with cardiac glycosides increase the figure of cardiac arrhythmias;
- Application of a non-steroidal anti-inflammatory agents may cause damage to the gastrointestinal tract and reduce the effectiveness of the latter;
- Simultaneous use of hypoglycemic and antihypertensive substances reduced their effectiveness;
- Combined therapy with androgenic anabolic steroid substances and can provoke swelling, acne rash and abnormal hair growth;
- The combined use of estrogens and oral contraceptive preparations Daksametazona toxicity increases.
If administered to pregnant injections, must inform the physician of all take the drug as their drug interactions with Deksametozonom may be negative.
conclusion
We found that Desksametazon is anti-inflammatory and antihistamine. One key feature of the drug is to restore the hormonal balance in a woman's body during pregnancy.
In situations where a patient having problems during pregnancy, due to increased content of male hormones (hyperandrogenism) Deksametozon restores balance, reducing production male hormones. The drug is taken during pregnancy in the minimum therapeutic dose, no toxicity and does not cause negative manifestations.
The development of serious pathologies may force the doctor to prescribe injections of dexamethasone during pregnancy. It should be understood that performing procedures justified the endangered status of the patient and is a necessary measure. Complications of some diseases can bring much more harm than the use of glucocorticoid drugs. In most cases, injections are very short period of time, and is converted to oral dosing with a further reduction in the patient.
Dexamethasone treatment during pregnancy is carried out under the strict supervision of the attending physician to conduct regular special hormonal studies.
sources:
Vidal: https://www.vidal.ru/drugs/dexamethasone__36873
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = 5db6dfe2-5236-4cd7-86de-d6f534373dd4 & t =
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