prednisolone
Hormonal medication Prednisone has a pronounced anti-inflammatory action. It belongs to the category average duration of exposure preparations. A good therapeutic effect of the drug due to its property to restrain the activity of leukocytes and macrophages, as well as to prevent their movement to the site of inflammation in the body.
In addition, Prednisolone prevents the immune system absorbing cells and interleukin accent. Effects on metabolism in adipose tissue does not allow the cells to capture glucose and stimulates lipolysis. However, because of its increased amount of the body is increased insulin production which leads to the accumulation of fats.
Unlike Dexamethasone Prednisolone from the fact that it changes more fluid and electrolyte balance: Shows potassium and calcium, but contributes to the detention of fluids and sodium. Antiallergic action more powerful natural analogue of hydrocortisone (4 times stronger) conditioned by the possibility to minimize the number of basophils and reduce the production of biologically active components.
dexamethasone
Dexamethasone acts about as well, but biomechanism its impact is a little different. This is a long-acting drug, so it is not administered in a lengthy treatment regimens. This analog of prednisolone provokes an increase in triglycerides, fatty acids and cholesterol. In addition, this medicine can cause hyperglycemia.
The drug is practically no effect on the water-salt balance and does not affect the amount of electrolytes. Dexamethasone is considered ten times superior analogue of natural cortisone. Inflammation localized in the body by acting on eosinophils and mast cells, as well as increases the stability of the membranes.
The similarity of drugs
Often immediately say which is better Dexamethasone or prednisolone is difficult because both of these tools are to the same category of drugs - glucocorticosteroids, ie a natural substance produced by the cortex adrenal.
They have a number of similarities:
- Unlike natural hormones and dexamethasone and prednisolone exhibit greater activity at lower doses;
- It has the same good anti-inflammatory effect on the body;
- Good relieve allergic reactions due to its ability to release histamine from mast cells;
- Protivotoksicheskoe exert effect;
- Immunosuppressive properties of both drugs equally effective in reducing the perturbation of the immune system;
- Used in anti-shock therapy as greatly increase blood pressure;
- Are used in the same indications.
Dexamethasone and prednisolone are widely used both in the provision of emergency care, and in the fight against systemic diseases.
What is different from Dexamethasone Prednisolone
Despite the fact that these medications belong to the same drug, the differences among them are:
- The duration of action. Prednisolone activity in the body is about 24-36 hours, while Dexamethasone can act to 72-96 hours;
- the impact of power. Prednisolone is much weaker counterpart;
- The difference between dexamethasone and prednisolone lies in the mechanism of action, so the body goes through different processes, often bringing negative results in certain situations;
- It has different effects on water-salt balance in the body.
During long-term treatment regimens, as well as during pregnancy, it is better to replace Dexamethasone Prednisolone, because it will reduce the risk of side effects. Therefore, I believe that these drugs are full analogues can not each other.
Which drug best
Choosing what's best Dexamethasone or Prednisolone, you must follow the doctor's recommendations. This is due to the fact that each of these different drug dosage base material. It is known that various drugs, which include natural hormones affect the body in different ways. For example, hydrocortisone 4-fold weaker metipred or triamcinolone and 20% stronger than prednisolone. At the same time Prednisolone is 7 times weaker than that of dexamethasone and 10 times weaker than Betamethasone.
Stopping at one or another hormonal agent, doctor necessarily take into account the extent of the disease and the general physical condition of the patient. Of course, in each particular case the physician will choose an appropriate medication, but never recommend taking along with dexamethasone drug prednisolone.
When used this group of drugs
Preparations made by the adrenal cortex hormone is used in therapy:
- substitution (if required reduction of glucocorticoids in the body's own);
- supressivnoj (for relief of the desired production of other hormones);
- pharmacodynamic (symptomatic effect).
In the treatment of some diseases doctors prefer to try to replace prednisolone or dexamethasone analogues in the case of injuries and changes vessels and tissues of different etiology in fevers, certain types of anemia, infectious mononucleosis, pancreatitis or exacerbation shock states.
Analog Prednisolone - Dexamethasone is used in severe manifestations of inflammatory conditions, sepsis, peritonitis, anaphylactic shock, asthma or multiple sclerosis.
Methods of Use
The dose of drug (prednisolone or dexamethasone) can be adjusted by a specialist. We must not forget that the glucocorticosteroid drugs are potent medication substances that can cause serious harm to the body.
Acceptance of these drugs must be used under medical supervision. The daily dosage of prednisolone in the period of acute conditions usually 20-30 mg, and this rate is divided into several doses over 24 hours. As the amount of stabilization of the drug is gradually lowered to 5-10 mg per day. In exceptional cases, allowed a one-time increase to 70-90 mg of prednisolone. In such situations the drug is administered intravenously. The maximum dose for a child - 1 mg per kilogram of body weight.
Sometimes it is better to use an analogue of Prednisolone - Dexamethasone. In critical situations, you can also use a lot of drugs, but then the dose is gradually reduced.
During the prolonged use of glucocorticoid agents must be carefully controlled water-salt balance in the body and the blood glucose level. To eliminate the occurrence of hypokalemia, with prednisone, dexamethasone or their analogues is usually administered potassium supplements.
sources:
Vidal: https://www.vidal.ru/drugs/dexamethasone__36873
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = 5db6dfe2-5236-4cd7-86de-d6f534373dd4 & t =
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