Operating principle
Dexamethasone entering the body begins to interact with the cell receptors, it penetrates into their nucleus. It inhibits inflammatory mediators by inhibiting the process of their release from mast cells and eosinophils. Means of reducing capillary permeability and stabilizes cell membranes.
Antiallergic effect is due to reduced synthesis of mediators of allergy histamine release process inhibited, suppressed the development of lymphoid and connective tissue, the sensitivity of cells to mediators of allergy decreases. This helps to reduce edema.
Given expressed antiinflammatory, decongestant and antiallergic effects used in sinus Dexamethasone justified.
Dexamethasone affects the protein, fat, carbohydrate metabolism. When ingested it is absorbed from the gastrointestinal tract for 1-2 hours. poluvyvoda period of the plasma is 4.5 hours, fabrics - up to 54 hours.
Composition, form of issue
The sales agent is in the form of tablets, solutions, drops. The main active substance is Dexamethasone (in solution - sodium dexamethasone phosphate).
Dexamethasone is included in the resources for the common cold, that are assigned for acute, chronic rhinitis, rhinopharyngitis, sinusitis. This corticosteroid is one component spray Polydex which has a marked antibacterial, vasoconstrictive, anti-inflammatory effects. Dexamethasone use in the sinus (including in complex tools) is possible only on doctor's orders.
Dosing with sinusitis
In various rhinitis treatment should select an audiologist.
The standard therapy for sinusitis circuit includes:
- antibiotics;
- antiallergic drugs;
- vasoconstrictor, decongestant medications.
The treatment regimen, a method of using drugs selected individually depending on the condition of the patient, the severity of symptoms, the intensity of the inflammatory process.
In exacerbations of chronic forms of the disease, doctors recommend injections of Dexamethasone sinusitis. It can be administered intravenously or intramuscularly in 1 ml in pure form or in combination with saline. This method of administration is most often used if the doctor suspects an allergic nature of sinusitis.
When sinusitis, rhinitis accompanied with purulent nasal discharge, designate the complex droplets. Their structure including Dexamethasone solution.
Depending on the state can designate a mixture of the following components:
- 1/2 ampoule dexamethasone;
- 1/2 ampoule dioksidina;
- Naftizina vial.
And other popular recipes for complex droplets. To treat sinusitis dexamethasone, you must combine it with other drugs. Dexamethasone can be used instead of hydrocortisone. A popular prescription antibiotic complex droplets. For their preparation take:
- 5 ml Farmazolina;
- 2 ml hydrocortisone;
- 10 mL of saline.
If a strong swelling of the nasal mucosa is allowed to add to the mixture 1 ml diphenhydramine.
Dexamethasone is used in pediatric practice. The child may designate nose washing solution prepared from 100 ml of saline solution, 5 ml Dioxydinum, ampoules Dexamethasone.
sources:
Vidal: https://www.vidal.ru/drugs/dexamethasone__36873
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = 5db6dfe2-5236-4cd7-86de-d6f534373dd4 & t =
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