Mechanism of action
Dexamethasone is a hormonal agent, sintenticheskim glucocorticoid. When ingested, it helps to reduce inflammation, allergy, relieve swelling. He also has an immunosuppressive effect.
Active substance inhibits the process of release of inflammatory mediators and allergy, reduces the permeability of the capillaries, the process inhibits histamine release from basophils and mast cells.
When injected into the blood it binds to transcortin (specific protein carrier). Active substance gistogematicalkie easily overcomes the barriers and into the tissue.
Given the anti-inflammatory effects, doctors often recommend taking Dexamethasone from pneumonia. Description placebo-controlled study in a hospital shows that when using dexamethasone:
- attenuated systemic inflammation;
- reduced the duration of treatment.
But it is prescribed in complex therapy. He helps to reduce inflammation, but no effect on the pathogens that provoked his appearance.
testimony
In accordance with the instruction Dexamethasone is administered intramuscularly or intravenously to patients which:
- aspiration pneumonia;
- pulmonary tuberculosis;
- tuberculous meningitis;
- other lung diseases.
The use of dexamethasone in the treatment of pneumonia and other respiratory tract lesions caused by the fact that this hormonal drug inhibits inflammation, reduces airway mucosal edemaDecreases eosinophilic infiltration of epithelial submucosal layer inhibits process erozirovaniya mucosa.
use method
Depending on the condition of the patient the physician may prescribe Dexamethasone in the form of tablets or injections. The dosage is determined by the patient's condition and age.
When pneumonia in a child give Dexamethasone can be only in emergency cases. Tablets physicians almost never prescribe. In severe cases it may be recommended intramuscular or intravenous administration of the drug to reduce the severity of symptoms. Dosage is calculated on the assumption that 1 kg of weight of the child is required 0,028-0,167 mg Dexamethasone solution. Adults may be administered at 4-20 mg drug (1-4 ampoules) 3-4 times a day.
In inpatient hospitals often prescribe electrophoresis with this drug. Under the influence slaboimulsnogo current drug ions penetrate into the tissues through the skin.
If pneumonia accompanied by edema of airway mucosa may recommend to bury the nose to reduce swelling and inflammation. Use is permitted even eye drops, one of the active ingredients which is dexamethasone.
Dexamethasone treatment of pneumonia without the use of other drugs is unacceptable. Prescribe antibiotics, antitussives, sometimes prescribe immunomodulators. In the treatment, it is desirable to listen to the doctor's recommendations, self-appointed agent to replace the analogy is not worth it.
Hormones are prescribed only in severe forms of pneumonia. At their diagnosis recommended inpatient treatment.
sources:
Vidal: https://www.vidal.ru/drugs/dexamethasone__36873
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = 5db6dfe2-5236-4cd7-86de-d6f534373dd4 & t =
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