Gonorrhea - venereal disease caused by a gram negative diplococcus - gonococcus (Neisseria gonorrhoeae). Why prescribe metronidazole for gonorrhea if gonococcus has no sensitivity to antibiotics? Let's try to answer this question.
Very often Gram-negative diplococci (gonococci) are combined with Trichomonas, Trichomonas pathogens. This combination promotes recurrent gonorrhea, as well as the rapid spread of infection throughout the reproductive system.
That is why the treatment regimen gonorrhea add Metronidazole, which successfully fights against trichomonads and prevents relapse.
pharmachologic effect
Metronidazole is a highly potent synthetic substance included in the group of nitroimidazoles and exhibiting antimicrobial and active protivoprotozoynoe impact. Interacting with deoxyribonucleic acid (DNA), located in the bacterial cells, Metronidazole blocks the production of nucleic acids, which causes the death of harmful microbes.
application
When complicated gonorrhea trichomoniasis, metronidazole should be taken in combination with other drugs that are active against Neisseria gonorrhoeae.
For example:
- Ceftriaxone + Metronidazole (or Trichopolum);
- genital infection when co-administered may Metronidazole (or tinidazole ornidazole) + dzhozamin or doxycycline;
- in the presence of candidiasis is added to the treatment regimen a drug belonging to the triazole series.
These schemes are considered to be most effective, given that the Metronidazole has the maximum therapeutic activity after oral use in men and women.
Dosage
Standard dosage metronidazole for treatment of gonorrhea: 500 mg (2 tablets of 250 mg), 2 times a day, 7 days a course. Possible single dose of 2 g of the drug.
Another treatment option may be to conduct a seven-day therapy dosage of 250 mg (1 tablet) three times a day.
The tablets should be taken by mouth without chewing.
Contraindications
Before starting treatment for gonorrhea, trichomoniasis complicated, make sure there are no contraindications to the drug, such restrictions are:
- coordination disorder;
- anemia;
- disorders of the central nervous system of an organic nature;
- hepatic disease activity;
- the first three months of pregnancy and during breast-feeding;
- hypersensitivity to substances forming part of metronidazole.
If there is at least one of the above contraindications, taking metronidazole for the treatment of gonorrhea, trichomoniasis complicated, it is strictly forbidden.
drug interactions
Sharing Metronidazole with other drugs can cause negative symptoms:
- simultaneous application of indirect coagulant increases their impact and may provoke bleeding;
- combined application with disulfiram can cause acute psychiatric disturbances and disorientation in space;
- combined application with preparations which contain lithium salts, to increase the toxic effects on the kidneys;
- dnovremennoe with ethanol (ethyl alcohol) causes nausea, retching and other side effects;
- if the treatment of gonorrhea Metronidazole applied Astemizole or terfenadine, may develop changes in the electrocardiogram, irregular heartbeat, fainting, down to heart block.
Before therapy uncomplicated gonorrhea, be sure to tell your doctor about all medications being taken at this time. This will reduce the risk of possible negative developments.
sources:
Vidal: https://www.vidal.ru/drugs/metronidazole__18699
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = 34a165f5-cd6a-4420-ac87-4d044867cd64 & t =
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