In diseases of the stomach caused by Helicobacter pylori, often prescribed metronidazole and clarithromycin. Both drugs belong to a group of antibiotics, so patients are interested in how to make Clarithromycin and metronidazole, to obtain the maximum therapeutic effect and to prevent possible side reactions. To answer the question, consider the characteristics of products and applied regimen.
Brief clarithromycin
The antibacterial agent contains an active component clarithromycin refers to a group of second-generation macrolides and possesses the following qualities:
- well into the tissue and body fluids;
- blocks protein synthesis in pathogenic microorganisms;
- It has anti-inflammatory effect;
- It is not destroyed by the action of hydrochloric acid;
- rarely has side effects.
Indications for use is:
- gastritis;
- gastroduodenitis;
- peptic ulcer disease.
You must take medication twice daily, 500 mg.
To date, Clarithromycin is considered one of the effective means to kill Helicobacter pylori.
After reading the characteristics, perhaps, the question arises, what is better Clarithromycin or Metronidazole. For this purpose it is necessary to compare the drugs.
Information about Metronidazole
Antibiotic nitrofuran series contains the active substance metronidazole. One of the first medicine was applied for the treatment of gastric diseases caused by Helicobacter pylori.
The drug has the following characteristics:
- a wide spectrum of action (effective against most bacteria);
- It affects the DNA of pathogenic microorganisms, causing it to dehydrate violates anaerobic respiration;
- resistant to gastric juice;
- gistogematicalkie barrier capable of passing;
- It accumulates in the body fluids, providing a therapeutic effect.
Indications are the same as for Clarithromycin. Taking medication 0.5 g three times a day.
Sometimes, instead of metronidazole appoint its direct analogues: Tinidazole or Trykhopol.
In the treatment of gastric pathologies prescribe metronidazole, clarithromycin simultaneously. This is based on the fact that drugs have different effects on the pathogens and their co-administration enhances the therapeutic effect.
How to provide treatment
Compatibility with Metronidazole Clarithromycin clinically proven, but both medicines destroying pathogens do not affect the level of secrecy acid.
But when diseases such as ulcer or erosive gastritis, it is important not only to destroy Helicobacter pylori, but also protect the gastric mucosa from further damage by hydrochloric acid.
To this end, in addition prescribe:
- Proton pump inhibitors. Inhibited the secretory activity of the glands is reduced and the acidity of gastric juice. Typically prescribed omeprazole, clarithromycin and metronidazole. Omeprazole should be taken once a day, and antibiotics - for individually selected doctor scheme;
- gastroprotectives. Envelop the gastric mucosa of the stomach, protecting it from damage and speeding up the healing of erosions and ulcers. The treatment regimen may look like this: De Nol, metronidazole and clarithromycin. Instead, De-Nol can be assigned to other drugs on the basis of bismuth: Vikalin, Ulkavis or Novobismol.
Co-administration of metronidazole and clarithromycin allows to destroy pathogenic bacteria faster, but to produce the desired therapeutic effect in association with antibiotics is necessary to drink means to protect the stomach lining. If this is not done, then the antibiotic therapy will be ineffective.
sources:
Vidal: https://www.vidal.ru/drugs/metronidazole__18699
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = 34a165f5-cd6a-4420-ac87-4d044867cd64 & t =
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