They have a different mechanism of action:
Chloramphenicol reaction blocks protein synthesis in the cell during exciter amino acid metabolism.
Metronidazole interacts with deoxyribonucleic acid (DNA) harmful microorganisms, blocking the synthesis of nucleic acids by bacteria.
application
Metronidazole and Chloramphenicol can be used for the treatment of the following diseases:
- infection heavy nature of the wound surface;
- infectious-inflammatory processes are localized in the abdominal cavity;
- urinary tract infections.
These pathologies are common to use both tools and is very difficult to determine what is best or Metronidazole Chloramphenicol, as pathogen may exhibit resistance to any of medicines, drugs and tolerability in each patient individual. Which drug will be more effective, it can be solved only by the treating physician, based on the general condition of the patient and the nature of the disease.
Contraindications
Before starting treatment with metronidazole and chloramphenicol should ensure there are no contraindications.
Chloramphenicol is prohibited in the following situations:
- diseases of the hematopoietic system;
- impaired renal and hepatic heavy nature of the functions;
- deficiency of glucose-6-phosphate dehydrogenase;
- cutaneous diseases, fungal types, as well as psoriasis, porphyria;
- during the SARS;
- preventive measures for the prevention of infection during surgery;
- pregnancy and lactation;
- age up to 3 years.
Metronidazole is contraindicated in case of:
- coordination disorders;
- anemia;
- violations of the central nervous system;
- pathologies of liver functions;
- breastfeeding and pregnancy (1 term).
use method
There are diseases in which doctors prescribe to take Chloramphenicol with metronidazole topically.
For example, for the treatment of acne is most often used with the following batter formulation: Chloramphenicol - 4 tablets (or powder), Metronidazole - 4 tablets and salicylic (or boric acid). Sometimes in this recipe can be replaced Chloramphenicol on doxycycline or other antibiotics. Ready means is applied to the skin several times a day.
However, such mixtures should be used only after consultation with the doctor, as self-medication may be dangerous to the patient. An overdose of these drugs can be serious violations in the work of various organs and systems.
side effects
Kazhdyi of drugs can cause symptoms of side effects, so the combination of metronidazole and drug Chloramphenicol, even in the most innocuous dosage must appoint a physician.
Negative effects may appear as follows:
- nausea;
- retching;
- headache;
- lack of coordination;
- disorders of hematopoiesis functions;
- allergic reactions.
If during use drugs develop adverse symptoms, it is necessary to interrupt treatment and consult a doctor. If necessary, it can be replaced Metronidazole Trichopolum.
conclusion
Metronidazole and Chloramphenicol are quite effective agents for treatment of infections. However, to compare products and their impact on the disease is not possible, since each is used in a particular situation where it is able to bring the maximum benefit to the therapy.
sources:
Vidal: https://www.vidal.ru/drugs/metronidazole__18699
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = 34a165f5-cd6a-4420-ac87-4d044867cd64 & t =
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