Ureaplasma infection is very common among women and men. Men ureaplasma often causes the development of urethritis. In women ureaplasma may cause vaginitis, cystitis, urethritis. Azithromycin is at a ureaplasma drug selection means. He actively assigned to both men and women. To date, there are strains of Ureaplasma resistant to azithromycin, but not so much. In general, the drug is effective in the treatment of ureaplasmosis.
Pharmacological properties of the drug form, indications, limitations
Azithromycin is a macrolide antibacterial drug group. There are several forms release drug - tablets, film-coated, 125, 250 and 500 mg of active substance capsules of 250 and 500 mg, powder for suspension at a dosage of 100 or 200 mg of active ingredient in 5 ml of finished suspension. Adult suitable tableted and encapsulated form of the drug. Children under the age of 12 shows an application of the suspension.
Azithromycin fights against Gram positive, Gram-negative bacteria, anaerobes bacteria causing diseases, sexually transmitted diseases. The mechanism of drug action based on the inhibition of synthesis of proteins in bacterial cells by binding to the 50-S ribosomal subunit and preventing translocation of peptides. Thus, the vital functions of bacteria is stopped. The drug accumulates mainly intracellularly - therefore there is a higher concentration in the tissues of the body, rather than in plasma. The maximum amount of active substance in the blood is recorded after 2-3 hours. Metabolized antibiotic in the liver tissue. Bile and urine output.
The drug has its indications and limitations to the destination.
Indications for use of Azithromycin:
- bacterial respiratory disease
- dermal diseases, caused by bacterial agents;
- Lyme disease;
- scarlet fever;
- urogenital infections (ureaplasmosis, mycoplasmosis, chlamydia);
- Infection with Helicobacter pylori part of complex treatment.
Medicament not shown dysfunction of kidney and liver, breast-feeding and pregnant (only indicated), for children weighing less than 5 kg (suspension) of at least 45 kg (tablets). Azithromycin is an analogue of Sumamed.
The concept ureaplasmosis, clinical manifestations
Ureaplasma bacterium was discovered in 1954 in a patient with ureaplazmozom. The microorganism is more than 200 species. In humans, 16 species of bacteria are active. Bacterial agents have a size much smaller than the standard bacteria. They have an intermediate position between viral and bacterial pathogens. Bacteria quickly adapt to changes in the environment.
Microorganisms have three-layer cytoplasmic membrane of the microcapsules and the like but without a cell wall. The causative agent is able to quickly get used to antibiotics when it is wrong application, the genome of a bacterial agent varies, creating a resistance to the antibacterial means. Fast adaptation does not explore the culturally bacterium, making it difficult to diagnose. The microorganism is not stained by Gram.
Some strains have ureaplasma resistance to antibacterial agents of the macrolide group. Ureaplasma not destroyed b-lactam antibacterial agents, as it has no membrane. Bacterial agent most often affects the lungs and genital tract, in particular the vaginal mucosa, urethra, bronchus.
Most often affects the reproductive tract ureaplasma. It occurs in both men and women. In male subjects more likely to develop urethritis. He is accompanied by itching, boeznennostyu during the emptying of the bladder. Patients Learning urination.
Women in contact with ureaplasma in genital tract occurs vaginitis, vaginosis, cystitis, urethritis and other gynecological diseases. The patient appear allocation, have an unpleasant odor, vaginal mucosa becomes inflamed, giperemiruetsya. The perineum is possible burning pain. After intercourse, sometimes appear meager discharge with blood.
Ureaplasma may also cause urethritis in women. It is manifested frequent urination, sharp pains when emptying the bladder, burning. The symptoms are very similar to cystitis. Many women present late to the doctor are treated independently.
Ureaplasma sexually transmitted infection carrier, asymptomatic. Ureaplasmosis also occurs when lowered immunity or AIDS. Normally, it is sometimes possible to identify ureaplasma composition or the so-called transient pathogenic flora. Normal microflora does not allow bacteria to multiply massively. When lowered immunity opportunistic flora activated and can cause disease.
Ureaplasmosis very contagious transmission of sexually, but infection can be prevented by using barrier contraceptives (condom). the bacterium is not transmitted through personal items, since it is not stable in the environment. Household by this microorganism is not transmitted.
Treatment with azithromycin ureaplasmosis
Therapy ureaplasmosis carried Drug 2: Doxycycline or Azithromycin. The effectiveness of both drugs is high. In most cases, the drug of choice is azithromycin. The therapy there is a rapid improvement in the patient's condition, symptoms of urogenital infections go away. A drug therapy is performed to men and women. When infecting another sexual partner of one necessarily will be ill or asymptomatic carrier, so therapy is both partners simultaneously. Curing can ureaplasma azithromycin in the absence of strain drug resistance. He was appointed to both women and men.
Treatment in women
The treatment regimen of azithromycin at a ureaplasma comprises administering interferons and of the antibacterial agent. 3-4 days prior to initiation of therapy, the patient is shown to take immunostimulants. They are administered intramuscularly once per day. Injections do well during antibiotic therapy. On the second day of treatment course therapy added antibacterial agent. After the drug begin to azithromycin. Treatment of women ureaplasma azithromycin is performed by a special scheme shock dosage.
Scheme treating a disease in women with mild symptoms and recent infection - once 4 tablets of 250 mg.
In the case of chronic ureaplasmosis flow diagram used:
- morning for half an hour before meals take 4 pills of 250 mg (or 2 500 mg tablets) - total dose of 1 g The next day, at the same time taking the same dose - 1 g, and so within 5 days.
- Further break - 5 days, at which time it is desirable to administer prophylactic treatment of candidiasis with drugs, said doctor
- then again repeat dose of azithromycin for the above scheme - over the next 6 days.
Treatment in men
Treatment with azithromycin ureaplasmas men carried out a similar plan. Beginning with immunomodulators and microbicides, and then finish treatment with azithromycin. Azithromycin at a ureaplasma is 5 days for 1 year The scheme is similar to the female. If ill the first woman, the men begin therapy at the same time with a partner. During the treatment is better to use a barrier method of contraception.
conclusion
Ureaplasmosis now treated effectively. With the right approach to the treatment of disease recurrence was observed. Before therapy, be sure to make a smear on sensitivity to antibiotics. It will appoint an antibacterial drug correctly. Self-treat ureaplasmosis azithromycin should not be. Before treatment should consult a doctor for further treatment tactics, calculating the dose.
sources:
Vidal: https://www.vidal.ru/drugs/azithromycin__24064
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = 464b69bc-52b8-420f-a2fd-5160efbe8523 & t =
Found a bug? Select it and press Ctrl + Enter
