Diprospan included in group glucocorticosteroid drugs and exhibits anti-inflammatory, anti-allergy and imunosupressivnoe action. In case of overdose can cause serious adverse effects, and therefore it is very important to know how many output Diprospan from the body.
pharmacological properties
The main active substance is betamethasone Diprospan in two chemical forms.
Betamethasone sodium phosphate after injection shortly actively absorbed from the injection site. It is this property of the active substance causes a rapid improvement of the patient's condition. Excretion of substances takes place over one day after the procedure.
betamethasone dipropionate It provides a long-term effect Diprospan due to slow absorption from the depot and the gradual metabolic reactions. Derivation of this component sufficiently long, the process takes place for more than 10 days.
After introduction Betamethasone actively binds to the plasma protein compounds (60 - 65%). When metabolic reactions taking place in the liver to form inactive derivatives. Excretion of the drug takes place mainly via the kidneys.
So, we found that Diprospan completely eliminated from the body within 10 days or more, and this occurs by means of the urinary system.
application
According to the instructions, Diprospan used for the treatment of the following diseases:
- pathologies of the musculoskeletal system, muscles and soft tissues;
- allergic conditions (asthma, bronchitis, allergic rhinitis, etc.);
- disorders of the skin, including collagenous diseases (atopic dermatitis, systemic lupus erythematosus, neyrodzhermit);
- oncologic pathology;
- primary adrenocortical dysfunctions (in combination therapy in conjunction with mineralocorticoids);
- other disorders that require treatment with glucocorticosteroids.
Overdose
Using Diprospan dosages exceeding the maximal therapeutic amount of the drug does not cause the development of life-threatening disorders, but its rapid elimination is difficult. If overdose is necessary to organize a thorough medical patient monitoring. Monitoring and electrolyte balance, particularly of sodium and potassium in the body, which at unbalance special means are used which increase their level.
Diprospan withdraw quickly from the body is not possible. The fact that the active substance of this drug binds to plasma proteins by 60 - 65%, which means that the dialysis procedure is useless for breeding. Injecting drug excludes the standard circuit, which are held in overdose by oral means. There is no specific antidote.
Side effects
In the following negative symptoms may occur while using Diprospan:
- electrolyte imbalance;
- disorders of the cardiovascular and nervous activity;
- disorders of the digestive tract functions;
- pathology of the endocrine, lymphatic and immune systems;
- functional disorders of the musculoskeletal system;
- disorders of the visual apparatus functions;
- skin lesions at the injection site.
Concomitant use of Diprospan alcohol can have a negative effect on the activity of the digestive system.
Based on the fact that Diprospan displayed completely on not less than ten days, with the development of adverse events is necessary to interrupt the use of funds and to consult a doctor for advice.
sources:
Vidal: https://www.vidal.ru/drugs/diprospan__264
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = 747e2fbf-1f0d-400e-8816-5a9a78dedb11 & t =
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