General information about the preparation
diprospan - glucocorticosteroid for systemic use. The drug is manufactured by the Belgian company in pharmaceutical dosage form of a solution in vials for injection. The packed box 5 vials of 1 ml each. Allergy prick Diprospan performed by specially trained personnel in compliance with the rules of antisepsis, the drug is administered intramuscularly or intravenously, depending on the indications.
The composition of the drug include:
- Betamethasone dipropionate in the form.
- Betamethasone sodium phosphate form.
- Auxiliary components needed to impart the formulation and the effective action of the basic substance.
Pharmacological effects Diprospan based on his corticoid activity. The substance reduces edema, inflammation, redness, has anti-allergic and immunosuppressive properties, influences metabolism of proteins, carbohydrates and lipids, has a weak mineralocorticoid effect and catabolic effect on all kinds of exchange.
Once in the body, Diprospan binds to protein carriers, transported in almost all organs and tissues has systemic effect. One of the properties of matter - immunosuppressive function, which is linked and anti-allergic effect. Acting on the immune system, suppresses Diprospan cell output, of mediators of inflammation and allergies, not allowing to develop a pathological or physiological response.
Since physiological reaction to inflammation of the body has an adaptive and useful value, it should be used Diprospan Only when the body can not for a relatively long time to cope with abnormal process. This rule does not apply to allergies. In allergy Diprospan can also be used as a first line drug (E.g., rhinitis).
Pharmacokinetic parameters diprospana associated with high activity, and base material to the dosage form. Intramuscular and intradermal injection of the drug allows the active substance to quickly reach target organs and start to act. The half-life is long enough, totally drug appears 10-15 daysThat allows you to use Diprospan for the course of therapy, and not for a single application.
Treat diprospanom allergy follows when there is pronounced edema, inflammatory response, active allergic process is not amenable to non-hormonal therapy agents. Without prescription drug is not recommended to take, as not all types of allergies can be treated diprospanom. In some situations, can only harm the body, taking the medicine without prescription.
The spectrum of indications for use
Diprospan helps against allergies and other negative symptoms caused by a number of causes and conditions:
- Inflammation of the muscles of the cervical spine, chest, legs, lower back.
- Fibromyalgia, muscle pain, inflammatory joints.
- The inflammatory response in the joint cavity, caused by traumatic injury.
- Degenerative disease of the cartilage - osteoarthritis.
- joint inflammation caused by gout.
- Bronchial asthma, endogenous and exogenous.
- Keloids and scars.
- Chronic non-infectious skin disease - psoriasis.
- Rhinitis, with allergies.
- Abnormal hair loss.
- Immune inflammation of the large intestine.
For all these diseases and allergies Diprospan assigned as a second-line therapy after failure of the primary.
If we talk about allergies, the spectrum of indications Diprospan cover conditions such as:
- Rash generalized, spreading diffusely throughout the body.
- Anaphylactic shock caused by elevated and inadequate reaction to the allergen.
- Angioedema and other severe manifestations of allergic reaction.
- Frequent asthma attacks, which tend to flow in the form of status asthmaticus.
- The allergy caused by reception of corresponding medicaments.
- Rhinitis caused by allergy to any substance.
- Spring hay fever.
- Allergy on the skin.
In the last three Diprospan situation applies only if there is no positive dynamics from taking the usual medicines or first-line agents. Only after using all possible combinations of non-hormonal agents for the treatment of allergies should go on steroids.
range of contraindications
Allergies and other pathological conditions contraindications to Diprospan considered:
- Hypersensitivity of the main active substance or auxiliary components;
- Ulcerative defect of the stomach wall or duodenum;
- Endocrine diseases including diabetes first and second types, hypothyroidism;
- Pathology caused by bacterial, viral, chlamydial, mycoplasma agents;
- Thrombosis, accompanied by an inflammatory response in the damaged vessel wall;
- Tuberculosis is an active isolation of mycobacteria in the environment;
- Mental diseases, neurosis;
- Formulation of the vaccine in the next three months;
- Surgery on the intestine with the removal of the organ and the anastomosis;
- Severe renal insufficiency severity function;
- Fungal systemic nature of the disease;
- Hypertension is a high degree, a hypertensive crisis.
With careful preparation used for: thyroid insufficiency, liver cirrhosis, herpetic ocular pathologies analyzer threat complications gastric ulcer and duodenal ulcers, recently transferred to the surgical intervention of the gastrointestinal tract, severe muscle organs weakness.
side effects
When using Diprospan to treat ordinary allergies, especially without the recommendation of the attending physician, to be afraid of side effects such as:
- Increase in blood pressure, up to the dosage of hypertension;
- Violation of the heart rhythm, beats;
- Mental and neurological disorders, emotional lability, depressed mood;
- Striae on the thighs, abdomen, buttocks;
- acne;
- Exacerbation of peptic ulcer disease, complications of chronic pathologies of the gastrointestinal tract;
- Visual disturbances and accommodation;
- myasthenia gravis;
- dry skin, thinning hair and nails;
- weight gain;
- Reduced immune body forces (Diprospan possesses immunosuppressive effect);
- Violation of ovulation and menstrual cycle disorder;
- Reducing the work of the adrenal glands that normally secrete a hormone similar diprospanom;
- Allergy to Diprospan - a rare phenomenon, as betamethasone, part of the drug - an analogue of the natural hormone of the adrenal cortex.
The risk of side effects increases, if there are problems with the above organs and systems. When the unwanted effects should consult a specialist to decide on the possibility of extending the treatment of allergy or another condition diprospanom. If necessary, the drug is replaced analogue or selected non-hormonal agent.
admission rules
The drug is available in injectable form and is used in a clinic laboratory or hospital procedural cabinet. Diprospanom injection is a nurse or trained personnel. If necessary, use in home use sterile disposable material. Spent a syringe, gloves and opened the vial should be disposed of after the injection formulation.
Injections can also be made intramuscularly, intra-articular, periarticular in the area inside the joint capsule, intradermally. If there is a focus on the skin, you can enter a medicine in the hearth.
In anaphylactic shock administered to 2 ml intramuscularly. If necessary, the inefficiency and the patient is transferred to the injection administration of glucocorticosteroids by infusion pump. Under conditions not requiring immediate administration diprospana, allergies, chronic diseases administered to 2 ml of the drug in the upper outer quadrant of the buttocks. For the treatment of rhinitis, allergy-induced pollutants, using a dosage of 0.5 ml. Glucocorticosteroids administered intradermally into each nostril.
The course of treatment may be a few injections, may last up to a month. Duration of the course of therapy calculates the treating specialist on the basis of the positive or negative dynamics, the presence or absence of side effects. Often stabbing Diprospan for allergies is not recommended, as the adrenal glands secrete a hormone similar to normal, no longer work. Courses of treatment can be performed several times a year.
Ability to use during pregnancy
For the treatment of allergy Diprospan prohibited during the period of gestation of the child, as well as during the lactation period. Safety of the drug has not been proved. To remove allergy symptoms better to use proven tools which are safe for the fetus and the expectant mother. If the reception Diprospan vital issue needs to be addressed with a gynecologist. During breast-feeding and the need for the appointment of corticosteroids should be transferred to artificial feeding the baby.
Specific guidance and the possibility of overdose
According to the instructions, Diprospan can not be used in the joint cavity at dislocations. When using the drug for 2 weeks or more, you should regularly donate blood the determination of glucose, since it is possible to increase with the development of the relevant symptoms. Under the skin and intravenous medication is not introduced.
Avoid concurrent use with non-steroidal anti-inflammatory drugs, as this increases the risk of ulcers of the mucous membrane of the internal organs of digestion.
Overdose is possible with prolonged uncontrolled reception Diprospan excess treatment. Cases of acute overdose are not fixed. During treatment it is necessary to monitor the sodium, potassium, calcium in the urine and blood. At higher levels of electrolytes to see a doctor for further instructions to eliminate the excess.
analogue instruments
For the treatment of allergy, if not approached Diprospan, you can use the analogy of having a pronounced anti-inflammatory, anti-allergic and immunosuppressive effect. Analogue Diprospan allergy: Betaspan original Betamethasone, Depos, Tseleston and other medications.
Benefits diprospan
In the pharmaceutical market there is a large number of analog drugs and generic drugs for the treatment of allergies. However, Diprospan demand and get a good estimate of consumers and physicians. The advantage of the drug is that it quickly becomes effective, with a long time circulates in the body, creating an effective cumulative concentration. This effect is useful for the relief of exacerbations of chronic disease and the transition process in complete remission.
conclusion
Diprospan allergies used in situations where the use of hormonal agents is inevitable. In all other situations, you should first try a non-hormonal agents, as steroids - it's always a large number of side effects. When using Diprospan guaranteed long for allergies, persistent action, can achieve remission of chronic pathology.
sources:
Vidal: https://www.vidal.ru/drugs/diprospan__264
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = 747e2fbf-1f0d-400e-8816-5a9a78dedb11 & t =
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