Information about how many takes effect Afobazol is contained in the summary medicines results of clinical observations and a review of people receiving treatment with this drug. When hypersensitivity to the active component efficiency comes at the beginning of therapy, but in most cases it means observed after one week of use.
Description and application of medications
afobazol - a means of tranquilizers anxiolytic group with the code in the ATC N05BX04. The active substance acts fabomotizole. The drug is manufactured in the form of tablets with a dosage fabomotizole 5 or 10 mg.
The active component acts on Afobazol Σ1R (sigma1receptors) neurons in the brain. Fabomotizole stabilizes the gamma-aminobutyric acid (CNS inhibitory neurotransmitter) from benzodiazepine nerve endings and resumes their sensitivity to mediators containment NA activity of cells.
Afobazol not conducive to the development of addiction, sedation, withdrawal, dependence, drowsiness or impairment of concentration and memory. He gently acts on the body and has no toxic effect on the liver.
Indications for use Afobazol:
- somatoform disorder;
- abstinent condition caused by alcohol consumption or smoking;
- anxiety disorder (generalized or not refined);
- reaction to stress or related violation of adaptation;
- neurasthenia;
- Kleine-Levin syndrome;
- disorders of the autonomic NA;
- PMS;
- violation of adaptation to a change in lifestyle.
Tablets of 10 mg three times a day drink (30 mg / day) no later than 40 minutes after the consumption of food: substance so quickly absorbed and not irritating to the shell. Deadlines treatment course is 2 weeks, 3 months. The instructions stated that acts Afobazol an average of 7-14 days after discontinuation of treatment. This information is supported by the results of experimental studies of drug development and clinical observations during therapy.
Afobazol not use in patients under 18 years of age and pregnant women. If required, the means for receiving the child during lactation is transferred to artificial feeding. These restrictions - manufacturer precaution, because studies have not attended these groups of people, and it is unknown how the drug on the embryo or organism children. The medicine also can not eat with a lack of lactose, galactose intolerance or fabomotizole.
The period of effect of the drug on the basis of the study results
At the pharmacological level average Afobazol effect 50 minutes after consumption of the tablet. Active substance for 0.9 hours absorbed into the bloodstream from the gastrointestinal tract and distributed to peripheral vascular tissues, organs, with well-developed capillary network.
The maximum concentration (Cmax) In plasma is achieved not earlier than after 43 minutes, and is 0.06-0,20 ug / ml. In total, the drug acts on nerve cells 2,5-2.9 hours. Fabomotizole derived from the body as metabolites and partially unchanged in urine, faeces after a maximum of 190 minutes.
Tablet Afobazol quickly acts on Σ1 receptors - receiving from the first hour. Drug substance possesses neuroprotective properties and enhances bioenergetic resource NA cells. Together this leads to the recovery of neurons, normalize the functions of resistance to exhaustion due to stress or damage.
On the pharmacological level, directly on the nerve cells Afobazol takes effect on the first day of treatment, but the therapeutic effect of patients notice no earlier than the fifth day of therapy. In humans, improving the quality of sleep, he feels decline tearfulness, anxiety and the severity of its symptomatic manifestations in the stomach, intestine, heart. This is due to the fact that fabomotizole cumulative effect on nerve cells: their functions recover slowly during the first week of therapy.
The speed of action of the preparation according to the reviews of patients and physicians
Viktor Yanukovych, a neurologist, Volgograd
"Active ingredient Afobazol no effect on the reaction depressing nervous system cells due to stress. Many patients notice a relief at 10 hours of treatment at a dose of 30 mg / day. Therefore, for the rapid elimination of anxiety, and other symptoms of mental and emotional or nervous tension comprehensively prescribe a sedative or nootropic. "
David G., neurologist, St. Petersburg
"Portability Afobazol patients is good and there is addiction to a substance. But the drug has no effect in the treatment of neurotic anxiety or frustration. Many doctors agree with me that this means - a placebo without the therapeutic effect. "
Irina K., 29 years old
"Long was in a stressful situation in connection with litigation, and I'm a neurologist prescribed two-month course of the drug. On the question of how long the effect Afobazol, the doctor said that the nerve cells resume their sensitivity to neurotransmitters braking five days after receiving and only then comes relief. Therefore, in the initial phase of therapy he recommended drinking valerian. "
Oleg, a psychotherapist, Moscow
"The optimal treatment regimen afobazole - fabomotizole 30 mg / day for a month. Stable therapeutic effect is observed in many patients by the end of 28 days of regular use of tablets, so they do not need repeated courses of treatment. PMS, somatoform disorders and generalized anxiety medicine works at the end of therapy 3-30 more days. Such patients it shows take on a permanent basis with the non-durable intermittently ".
Elena Smirnova, pharmacist
"Afobazol gently eliminates symptoms of phobias, suspiciousness, depression, stress symptoms. The instructions stated that the therapeutic effect lasts up to two weeks after discontinuation, but reviews a small portion of consumers contain information that the drug acts only hours after completion of the course. "
Ilkin Olga, pharmacist
"Active ingredient Afobazol compatible with ethanol, so it can be used in conjunction with alcohol-drug infusions in the treatment of alcohol withdrawal states. The drug does not prevent the influence of anesthetic agents with sodium thiopental, and based fabomotizole better drugs act with carbamazepine and diazepam. "
Stanislav, 31 years old
"Not able to adapt to the new conditions after the divorce: at the slightest disturbance was crying, and the doctor has prescribed Afobazol. Tablets made use of more than three weeks, but did not notice that the means of action have not yet got into surgery. The girls in the room were all nervous before the surgery, neither eat nor sleep could not, and I was calm, like a python in the afternoon. It became clear that the medication is helping. "
Karina, 38 years old
"I was diagnosed with a form of PMS and psychovegetative appointed Afobazol drink. The medicine is effective only during the course of treatment in 2 weeks, and then it disappears and the effect in the next cycle again showing signs of premenstrual disease. I will ask the doctor to change the medication. "
sources:
Vidal: https://www.vidal.ru/drugs/afobazol__8918
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = 371de6b3-e920-4e80-9e9a-7a458f7c9a89 & t =
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