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Noopept or Piracetam: which is better, and what is the difference, comparison, compatibility

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piracetam

piracetam - a pioneer among neuroprotective medicines, declared as a pharmacological agent in 1972 and has collected decades of clinical use. Its active ingredient - pyrrolidone having srednevyrazhennym psychoactive effect.

Piracetam is turned in neurons and blood cells of the neurotransmitter glutamate receptors, which in their turn activate acetylcholine receptors - the main stimulating neurotransmitter of the central nervous system.

Proven to accelerate the effect of piracetam memorization in learning (by forming new neural connections), to improve blood circulation the brain during hypoxia (oxygen starvation), increased accumulation of glucose metabolism and ATP (energy stocking substance) in cells brain. However pyrrolidone efficacy in the treatment of severe forms of dementia (dementia) and other neurodegenerative diseases recently disputed in this connection in Western Europe and the US the drug is registered as BAD.

Piracetam with noopept apply to OTC medicines in Russia.

The clinical efficacy of piracetam

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In Russia Piracetam appointed and efficiently used to combat memory disorders mild to moderate in children and adults (with the active mental activity), relief of symptoms of perinatal nervous system lesions in newborns, treating cerebral hypoxia of different genesis, removing toxic effects and infection brain.

Continuous clinical practice late (after 7 hours) the destination piracetam stroke patients without showed a significant improvement, so in 2007 RAMS announced Piracetam outdated and insufficiently effective drug.

The advantages of the funds can be attributed to non-toxic, deferred action, an extremely low risk of overdose, the possibility of birth.

Noopept

Noopept - modern preparation of national development, which entered the market in 1992. According to the statement from the Academy of Medical Sciences 2002, neuroprotective and neyrostimuliruyuschey efficiency Noopept Piracetam exceeds 1,000 times; drug accepted in clinical practice in Western Europe and the US.

When you want to compare or Noopept Piracetam in strength, it is possible to pay attention to what the first of these agents in the composition comprises three active substances which have a synergistic action.

  • The main active substance is an amplified version of glycine - neurotransmitter, which also inhibits the selection of excitatory amino acids and enhances their holding signals. Glycine has been known since the 19th century and is widely used in neurology and psychiatry as a mild sedative and psychoactive funds, however inconvenient in reception (requires sublingual absorption) has a low degree of absorption and, consequently, efficiency.
  • The second active component is Noopept proline - structural protein unit, which provides a rigid coupling peptide and glycine molecules prolong its effect. Self-proline have an inhibitory effect on the central nervous system and is used for stress, depression, fatigue and active mental activity, improves memorizing and storing information.

Furthermore, antiatherogenic activity expressed substances allows to consider it as a preventive and therapeutic agent for cleansing the blood vessels of atherosclerotic plaques and in the restoration of blood flow brain.

  • Ether phenylacetyl provides cyclic link in the overall molecule, which does not allow it to quickly disintegrate into fragments unstable and prolongs the action of Noopept on the body.

All three components in contact with the gastrointestinal tract are transformed into tsikloprolilglitsin, which acts as a stimulator of the release of acetylcholine, power of nerve impulses, oxygen and carbohydrate providing cell stabilizer neural connections formed during memorization, glutamate excess and catalyst activator growth neurons. The neuroprotective potential of a substance is significantly higher than piracetam. Noopept available in tablets, absorbed in the intestine and does not require a long resorption as glycine.

Clinical efficacy Noopept

Noopept effective for the treatment of memory disorders and attention of mild, moderate and severe, emotional instability, the lack of a deep phase of sleep, headaches, vascular nature, removes the effects of intoxication, hypoxia, ischemia, and brain injuries, has neuroprotective effects with stress and other injuries of the brain, it acts as a powerful antioxidant and anti-inflammatory factor. Indirectly Noopept normalizes the endocrine system by stimulating the hypothalamus.

Comparative effectiveness analysis

In the treatment of vein amnesia and other memory disorders major difference between piracetam and Noopept is that the first of these two drugs active against the hippocampus - a brain structure that is responsible for long-term memory, emotions and Attention. Therefore Noopept provides not only remembering, but also organize, store, productive processing and retrieval of information, as well as spatial and muscle memory.

In general, as compared with piracetam Noopept shows broader spectrum activity nootropic, Has a higher response rate and duration of effect. In clinical studies indicated a positive effect of the drug on patients not only with brain injuries, but with Alzheimer's disease, cerebral ischemia and other types of severe cerebral circulation.

Currently Noopept considered more modern and efficient analog of piracetam. Noopept does not possess a sufficient amount of studies regarding the use of security, but apparently both drugs equally harmless.

Disadvantages Noopept preparation:

  • A large number of active and auxiliary components. Complex composition increases the list of contraindications, intolerance, and the possibility of allergic reactions.
  • We do not study the effect of the drug on children during pregnancy and lactation. At the present time for these groups of patients Noopept banned for use.
  • The agent can raise the blood pressure of hypertensive patients.
  • Not Applicable exact dosage for chronic disorders of the kidneys and liver.
  • Noopept price exceeds the value of piracetam is 4-6 times. If you want to replace Noopept cheaper analogues, can draw attention to glycine or vinpocetine.

Both drugs have limitations when operating machinery and driving vehicles and generally well tolerated. For the prevention of the headaches associated with the consumption of choline, recommended to supplement intake cholin food (poultry eggs, organ meats) or dietary supplements (lecithin, vitamin B4 and B5).

drug combination

In combination Noopept simultaneously with piracetam can replace a bunch of Glycine - Piracetam. Developed generic combining both drugs in accordance with the recommended standards of reception (Piracetam Noopept to as much as 1000: 1), but their efficacy and safety is not clear. Manufacturers claim such a combination and synergistic softening effect of piracetam on which the patient may experience a headache due to a lack of choline.

Presumable bunch effect:

  • strengthening of co-operation;
  • relief of headache as a side effect;
  • piracetam extension activities;
  • expansion antiamnesic action due to stimulation of multiple types of memory;
  • a synergistic improvement in the perception of the eye and ear.

sources:

Vidal: https://www.vidal.ru/drugs/piracetam__41225
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = c6acfe2a-e191-431d-90ad-3d92e4f3eb7d & t =

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