Milgamma and Niacin - preparations of vitamins of group B. Despite the fact that these substances are water-soluble vitamins and are present in the form of its own derivatives in the human body, physicians do not prescribe prick simultaneously Milgamma and nicotinic acid. If the patient is discharged and then, and another medication, usually while taking medications and their dosage forms are different.
Vitamins in preparations
milgamma
Milgamma solution for injections - vitamin B complex, sold in vials of 2 ml.
Each ampoule comprises:
- 0.1 g of vit. AT1 (Thiamine hydrochloride). Thiamine derivatives are involved in the metabolism of carbohydrates, especially - in the neurons. Member of the tricarboxylic acid cycle and the process of storing energy in the bonds of ATP.
- 0.1 g piridoksinfosfata (vit. AT6). Involved in amino acid metabolism, synthesis of adrenaline, histamine, serotonin, dopamine. Improves neyroprovodimost at synapses. Do (potentiates) the effect of thiamine.
- 1.0 g of cyanocobalamin (vit. AT 12). It has the ability to stimulate hematopoiesis, is involved in the metabolism of nucleic acids, potentiates the synthesis of myelin sheath surrounding nerves. It exerts an analgesic effect in damaged nerve fibers and structures.
- Lidocaine hydrochloride 0.02 g - lokal agent which reduces discomfort when administered intramuscularly preparation.
Milgamma used as a medicament for diseases with impaired neural and neuromuscular conduction:
- multiple sclerosis;
- neuritis, neuralgia craniofacial pairs nerves;
- polyneuropathy;
- osteochondrosis;
- hyperchromic anemia (In12-scarce);
- ganglionitis, radiculitis, and plexites plexopathies.
In the regular course of treatment the patient does Milgamma intramuscular injection 1 ampoule per day in acute (5-10 injection), and then - 1 prick 2-3 times a week (for 20-25 days) until the total duration of the course of therapy at least months. Most neurological diseases require 2-3 month courses.
vitamin B3 (RR, nicotinic acid)
Niacin (vitamin B3, RR) - in the form of the active metabolite of niacinamide takes part in the regulation of lipid, protein and carbohydrate and purine metabolism in tissues. The use of vitamin B3 can improve regional blood circulation of the head, upper limbs and trunk; It leads to a reduction of atherosclerotic plaques in blood vessels, lowers cholesterol and low-density lipoprotein in the blood, improved cerebral blood flow due to the vasodilatory action, is involved in proton transfer in the mitochondria (NAD NADP).
Nicotinic acid is produced in 1 ml ampoules containing 0.001 g of vitamin PP.
It is used to treat:
- autoimmune dermatitis and allergic component;
- atherosclerosis, pulmonary forms of diabetes;
- Vitamin B3 deficiency (pellagra);
- in the complex - neuritis of the facial nerve;
- multiple sclerosis;
- osteochondrosis.
Nonspecific regimen Nicotinic acid reduces to intramuscular injections 0.0025 g per day for 2 weeks. For injections need to use a 5.0 ml syringe, as a deeper introduction of the drug into the interior of the muscles is less painful and more efficiently. After insertion of the needle drug administered slowly, gradually, to prevent occurrence
If we compare the nicotinic acid and Milgamma, it becomes apparent that Milgamma has a broader spectrum of action on the nervous system and the scope of the treatment of neurological diseases. Nicotinic acid has no pronounced effect on the conductivity of the nerve fibers, so it can not be considered Milgamma analogue drug. It is also evident if we compare the composition of these drugs.
Compatibility
Can I take Milgamma taken with nicotinic acid? According to the instructions, it was not observed features of drug-drug interactions between these medicines and directions about the inadmissibility of their simultaneous introduction absent. But since Milgamma and nicotinic acid are available as separate means, making one injection of a mixture of these formulations is undesirable.
Physicians answers regarding simultaneous administration of these drugs differ: Some advised to give injections separately in the morning and in the evening, the other - to hold the injection at the same time of day. Because drug manufacturers do not indicate compatibility features Milgamma and nicotinic acid, then welcome them at the same time of the day is acceptable.
sources:
Vidal: https://www.vidal.ru/drugs/milgamma_compositum__3201
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = dc3ff3df-6316-4cad-b30f-e937214a56ba & t =
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