Replying to a question what is better - Piracetam or Cortexin - need to compare multiple metrics: efficiency, safety and economic benefits of application.
Comparative analysis of the effectiveness of piracetam and Cortexin
piracetam
piracetam - the first of nootropics with a 50-year history of clinical use in pediatrics, internal medicine and gerontology. The drug is a derivative of pyrrolidone (chemical relative of GABA - inhibitory neurotransmitter of the central nervous system).
The main thrust of the effect of piracetam:
- Activation of excitatory neurotransmitters - acetylcholine, dopamine and serotonin in part, provided that the active mental activity improves memory function. This allows you to use it to restore and enhance concentration and memory, but mostly for minor deviations in these processes.
- Piracetam also reduces the viscosity of the blood and increases the trophism of nerve cells, neurons, increasing the capture of glucose and oxygen, activating the carbohydrate and energy metabolism. This feature is effectively used in the treatment of anoxia and intoxication by external toxic agents and partly - endogenous substances under stress, neurosis and depression.
- Neuroprotection in diagnosing the disease is weak; Piracetam acts more as a preventive antioxidant.
However, the effectiveness of piracetam is most clearly expressed only in the treatment of various perinatal encephalopathies (mainly birth injury and hypoxia) in infants, improves hemispheric interaction (speech, systematization of information, planning) and eye coordination, it helps with training and mental work and child adult. Sometimes Piracetam helps to stop light emotional disorders. Severe vascular and neuronal brain diseases such as ischemia, stroke, Alzheimer's disease and other dementias Piracetam eases slightly.
In 2007, the Academy of Medical Sciences has recognized drug outdated and ineffective. If we compare with Piracetam Cortexin, then the last there is a more pronounced effect and wide.
Cortexin
Cortexin - hydrolyzate brain neuropeptides pigs and cattle, developed by Russian pharmacologists 30 years ago. All animal nootropics have multidirectional action and high efficiency not only for the elimination of disorders of mild and severe mental, but when treatment of severe brain damage resulting from traumatic brain injury, ischemic stroke (when injected in the first 6 hours), the age and acquired neurodegenerative diseases.
Act:
- Neuroprotective. Cortexin proven reduces lesion in ischemic stroke with the proviso that the treatment was started in the first 6 hours of the disease. Under the influence of the drug inhibited programmed apoptosis of nerve cells, reduced neuronal death from intoxication external and endogenous agents.
- Stimulation of neurogenesis. Peptide lysate allowed to induce the synthesis of neurotrophins - factors of the growth of new nerve cells. This feature allows you to recover Cortexin higher mental functions of the brain after suffering a massive stroke.
- Anti-stress effect by reducing cortisol levels and increase production of serotonin appears greater than that of glycine and other soft neuroleptics. Used in the treatment of severe neurosis, depression, chronic stress.
- Improving metabolism in nerve cells. Restoring the balance of inhibitory and excitatory neurotransmitters, optimizing the emotional sphere and mental activity.
- Antioxidant and anti-inflammatory activity.
Clinical studies, the ability to clearly define the scope Cortexin options held is not enough, however, the drug is a promising tool in a series of neuropeptide nootropics new generation.
Action Cortexin and piracetam is cumulative, however Cortexin higher response speed. Therefore, in some cases, are used in conjunction Piracetam and Cortexin at the beginning of the course.
Cortexin refers to prescription drugs and is represented only in the form of injections. Piracetam is used as in the form of injections, or in the form of tablets and capsules.
Security
Parameter |
piracetam |
Cortexin |
Contraindications |
Idiosyncrasy; hemorrhagic stroke; blood loss; extensive surgery; severe renal insufficiency |
idiosyncrasy |
Toxicity |
Absent |
|
side effects |
Allergy; dyspepsia; sleep disorder in the evening use; headache during choline depletion |
Perhaps - allergy. Theoretically possible toxic effect when used overdue means forgery or infected materials, but in practice, such cases were not observed; Local complications of intramuscular or intravenous administration. |
Use in infants |
allowed |
|
Influence of pregnancy and lactation |
The negative impact is not detected |
not found |
Effect on driving vehicles and working with machinery |
allowed |
Overall, both drugs are safe, well accepted by the body, but Cortexin shows better portability.
prices
Piracetam course to improve mental capacity for 2 months costs about 300 rubles. Course fee Cortexin of 10 injections equals an average of 1,000 rubles (as of 2018). Course of treatment complex encephalopathies calculated individually physician and depend on the stage and severity of the disease.
analogs Cortexin
Cere - foreign analogue Cortexin and the same age as Piracetam is extracted from pig brain. It is widely used in the treatment of ischemic stroke, traumatic brain injury and degenerative encephalopathies.
Aktovegin made of calf blood, has a regenerative effect on the blood and brain cells, and improves the oxygen supply to the muscle cells, in U.S. equated to doping.
Compatibility piracetam and Cortexin
The lack of toxicity of both drugs, as well as a weak and delayed action of piracetam is likely to provide an opportunity to apply Cortexin simultaneously with piracetam. It is advisable to combine the funds at the beginning of the course to accelerate the positive response of the central nervous system.
sources:
Vidal: https://www.vidal.ru/drugs/piracetam__41225
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = c6acfe2a-e191-431d-90ad-3d92e4f3eb7d & t =
Found a bug? Select it and press Ctrl + Enter
