Pharmacological properties, indication, to limit prescribing
Omez Nolpaza and belong to the group of proton pump inhibitors. The difference between Nolpazoy and omez in the form of the drug, the composition, the use in pregnant women, breastfeeding and children. To compare with Omez Nolpazoy need to study them in detail instructions.
Comparison of drugs
Characteristics |
Nolpaza |
omez |
The components of medicines |
pantoprazole sodium |
omeprazole |
shape |
Tablet form (40 mg, 20 mg) |
Encapsulated form of 20 mg, 10 mg, vials with powder 40 mg. |
testimony |
|
|
The difference between the drugs in their indications and limitations to the destination. Omez in powder form for injectable administration is not used in the allergic response, or intolerance to the drug components, sharing with erlotinib, posaconazole, nelfinavir and atazanavir. You can not assign an injection form for children under 18 years of age. Omez of bottles not shown breastfeeding.
Nolpazu not used in the presence of an allergic reaction. The drug is not administered in conjunction with antimicrobial drugs in patients with renal and hepatic disease. The medicine should not be prescribed to patients with dyspeptic symptoms on a background of neuroses.
Nolpazu carefully used in patients with liver disease. In appointing the drug to patients in this group, then after the end of therapy is carried out laboratory monitoring of transaminases. Carefully prescribed medication to patients with ulcerative lesions of the intestine, the presence of bleeding in the digestive tract, as well as low levels of vitamin B12.
Pharmacological properties of drugs
Omez Nolpaza and have similar pharmacological properties have been assigned to one group of drugs. Guide describes Omez that contains in its composition of omeprazole. It is considered a weak base. Cumulated drug in the gastric mucosa, reduces the work of the proton pump (H enzyme+/TO+-ATPase). A feature in the pharmacokinetics omez is that the drug reduces the formation of well-hydrochloric acid. The intensity of the oppression of the secretory activity is dependent on the dosage of the medication. The greatest effect of the treatment is recorded at 4 days after regular use of medication.
Omez actively fighting by Helicobacter pylori. The effect of treatment is achieved in a combination with other antibacterials. While taking medication gastric mucosa heals more quickly go to erosion, reduces the frequency of relapse of peptic ulcer, bleeding frequency decreases. When using means increases the amount of gastrin in the blood stream. Connection of the secondary pathogenic flora on the background of prolonged use of omeprazole (Salmonella, Campylobacter, Clostridia). This is caused by decrease in the concentration of hydrochloric acid which bears a protecting bactericidal function.
Omez very well penetrates the mucous membrane into the blood. The maximum amount of the drug is recorded after 30-60 minutes. The bioavailability of the active drug component is 30-40% (single application), 60% (term use). The presence of food in the stomach does not affect the rate of penetration of the drug through the mucosa of the stomach. Cleavage of omeprazole occurs in the liver tissues. Derived drug with urine and feces.
In patients with renal disease, the elderly, omeprazole does not require a dose adjustment. In the presence of liver tissue dysfunction omeprazole rapidly digested, the bioavailability is increased.
Nolpaza has similar effects from the therapy. The composition of the drug include pantoprazole. This material relates to benzimidazole derivatives. Nolpaza reduces work H + / K + ATPase. The treatment increases the concentration of gastrin.
Nolpaza into the bloodstream in a short period of time. Biodostepnost drug up to 77%. The maximum amount of the drug is recorded over 2-2.5 hours.
At the same time omez Nolpazu should not take. Co-administration of drugs can lead to a drastic reduction in gastric acidity. This can cause connection pathogenic flora, disruption of digestive functions. Before starting the use of drugs, should consult a doctor, to strictly follow its recommendations. Results of treatment of both drugs are very good but (for reviews million patients) Nolpaza more effective than Omez.
Terms of Use omez
Omez actively prescribed for diseases of the digestive tract to relieve pain, dyspeptic symptoms, reduce the frequency of exacerbations. The medicine is produced in capsules and vials with powder for injection administration.
The capsules should be drunk within 30 minutes before a meal, drink water. No need to chew the capsule. If the patient can not completely swallow capsule form of the drug, then it is allowed to open, dissolve in acidified liquid, and then drink. You can not drink the drug with milk or carbonated beverages.
Patients with ulcerative damage to the digestive tract mucous administered drug dose of 20 mg per day (2 tablets of 10 mg, 1 to 20 mg tablet). 40 mg per day is shown drinking medication in the presence of resistant strains to antibiotics. Coursework omez therapy is 14 days - 1 month. In the presence of gastric ulcer medication shown to apply for 1-2 months. If the patient has reflux esophagitis, the treatment prescribed to 20-80 mg per day. The duration of the course of 1-2 months.
With the increased secretion of hydrochloric acid treatment is shown in capsules. Taking the drug need to 60 mg. The dose is better distributed into several stages per day. If the patient's condition has not improved, the dose was increased to 80-120 mg per day.
To reduce the Helicobacter pylori activity of the drug is used as a part of complex treatment. Together with antibacterial agents Omez be taken in a dosage of 20 mg twice per day. The drug is often combined with clarithromycin and amoxicillin. To increase the effect of drug therapy may be used dosage of 40 mg, a term therapy extend up to 7-10 days.
If the patient has a pathology of the digestive tract caused by prolonged use of nonsteroidal anti-inflammatory drugs (NSAIDs), something Omez administered 20 mg every day before the morning meal. This prevention scheme is assigned to the background of NSAID therapy throughout the course. For the treatment use omez 40 mg per day rate at 1-2 months. Mendelson's syndrome (aspiration pneumonitis) treated with a dosage of 40 mg once per day.
A child older than 2 years of age (weight 20 kg) at reflux esophagitis Omez administered 20 mg dose once per day for 1-2 months. Also, the dosage can be calculated by weight: 0,7-3,3 mg per 1 kg of weight of the child.
If a child 4 years or more (weight more than 20 kg) in ulcerative lesions of the mucous membrane of the digestive tract (with the presence of Helicobacter pylori bacteria) treatment is administered in a dosage of 20 mg once per day. Therapy was performed in conjunction with antibacterial agents. The dose can be calculated by weight: 1-2 mg per 1 kg of weight of the child.
In diseases of the renal system dosage adjustment is not carried out. When liver tissue pathologies drug dosage should not be more than 20 mg. In the elderly, during pregnancy and breastfeeding medicine administered at therapeutic doses.
Omez solution for infusion reference is made in the form of powder. Before use 1 drug vial should be dissolved in 5% dextrose solution (100 ml) or with saline (100 mL). The vial should be mixed well in order not to remain pieces of dry matter.
Nolpaza is an analog omez. They have similar pharmacological effects. Omez Nolpazoy together with other similar drugs and is not used in order not to cause severe reduction in the amount of hydrochloric acid in the stomach.
Terms of appointment Nolpazy
Nolpazu appointed interior. Swallow the tablet should be completely with water. It is better to drink a medicine before eating in the morning.
In the presence of reflux oesophagitis Nolpazu using 20 mg (1 tablet) per day. Treatment lasts for 2 -4 weeks. In some cases, the doctor may extend the treatment for 2 months. Prevention of reflux disease is carried out in the same dosage. When there is used the risk of exacerbation dosage of 40 mg. Once per day. dose reduced by half while improving the state.
In the presence of Helicobacter pylori infection Nolpazu used in dosage of 40 mg 2 times per day. Medication necessarily combined with other antibacterial agents. Take tablet form in the morning and evening.
In the presence of Zollinger-Ellison syndrome (increased formation of hydrochloric acid) Nolpazu administered 40 mg 2 times per day. When the severity of the disease is allowed to increase the dosage to 80 mg.
If the patient has liver pathology Nolpazu then take 20 mg. Before starting therapy should be tested for liver aminotransferases. After the treatment is performed in the control of blood biochemistry, liver enzymes.
Nolpaza does not have sufficient clinical data, so it is not used in pregnant women, lactating women. Do not use the drug in children under 18 years. If necessary, drug therapy should be replaced Nolpazu other similar means. For pregnant women, children, and during breast-feeding is perfect Omez Nolpaza instead. Doctors do not recommend Nolpazu taken together with the drug Omez.
conclusion
Omez Nolpaza and are very effective drugs against the digestive tract diseases. Apply them follows the instructions. Before using it is necessary to see a doctor. Nolpaza considered to be more effective, but it is not used in children, lactating women and during pregnancy. Omez allowed in this group of patients.
sources:
Vidal: https://www.vidal.ru/drugs/omez__619
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = 5ab108ba-8f63-4e81-982c-a6b4a1ec47ac & t =
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