In order to understand what properties of these substances are used for the treatment of disorders of the mucous membrane of the digestive tract, let's take a closer look to them.
pharmacological properties
The main active ingredient is Omeprazole omez exhibiting anti-ulcer properties. During this exposure mechanism component inhibits the production of hydrochloric acid by blocking operation proton pump in the gastric glands. The daily intake of 20 mg normalizes acid component food juice per day.
Colloidal bismuth subcitrate - acting De-Nol component helps formation of a film which protects the mucosal surface, which prevents the development of ulcers and erosive lesions, providing protection from the effects of food and juice helps scarring existing damage. The drug reduces the activity of pepsin and pepsinogen as well as promotes the accumulation in the problem domain of the epidermal growth factor.
Quite often, doctors recommend the use of Omez simultaneously with De nolom, Especially in the presence of inflammation in the stomach caused by the bacterium Helicobacter pylori, since both drugs were well help her destruction.
Indications for use
De-Nol is used to treat:
- ulcerative lesions of the gastrointestinal tract (including lesions caused by Helicobacter pylori);
- inflammation and lesions of the mucous membranes of the digestive system in the acute phase (gastritis, gastroduodenitis), including those caused by exposure to Helicobacter pylori.
Indications for use omez are:
- therapy and prophylaxis of ulcerous and erosive mucosal damage (including prevention of lesions during the course of treatment with nonsteroidal anti-inflammatory drugs);
- gastroesophageal reflux disease type, reflux esophagitis (prevention and treatment of relapses);
- Combination Therapy damage the gastrointestinal tract, occurring under the influence of Helicobacter pylori;
- increased secretion of the stomach associated with the disease Zollinger-Ellison syndrome;
- therapy prior to surgery (prevention of Mendelson's syndrome).
If we compare with Omez De nolom, the differences in the application of these two means of course suschesstvuyut. However, the main purpose is the treatment of drug mucosal damaged or preventing its lesions.
Contraindications
Let's look at what are the contraindications to these medications.
Omez drug is contraindicated for the treatment of the following conditions:
- hypersensitivity to the drug;
- severe violations of the functional activity of the liver;
- perforation and intestinal obstruction (mechanical).
De-Nol is prohibited to use:
- if you are hypersensitive to substances included in the product;
- pathologies of renal function in severe.
Dosage and method of use
As frequently used therapeutic regimen in which the need to drink and De-Nol Omez together, consider the dosage and frequency of drug administration.
Therapy omez:
- gastritis, and gastric and intestinal - 20 mg daily, with a duration of 2 to 4 weeks;
- gastroesophageal reflux disease - 20 mg omez from one to two times per day for 2 - 4 weeks;
- prophylaxis of mucosal damage arising during treatment with non-steroidal anti-inflammatory agents - 20 mg per day, the duration of the course assigns the attending physician;
- ulcerative lesions that develop due to exposure to Helicobacter pylori - 20 mg for 1 - 2 weeks (together with amoxicillin or clarithromycin);
- Zollinger-Ellison syndrome - 60 mg omez per day, duration of the course is assigned to a specialist.
De-Nol used in the dosage - 1 tablet 4 times a day, or twice a day, 2 tablets.
For patients 8 to 14 years old, reception is at a dosage of 1 De Nola tablet twice a day.
Children from 4 to 8 years - 8 mg per kilogram of body weight per day. This number should be allocated on two steps.
Duration of therapy De nolom from 10 to 14 days, however, if necessary, the physician can change the circuit and increase the duration of treatment and 8 weeks.
Mucosal lesions, arising from exposure to Helicobacter pylori, require combination therapy. Most often used for this purpose:
- De-Nol - 140 mg (four times a day);
- Omez - 20 mg (twice daily);
- Tetritsiklin - 500 mg (four times a day);
- Metronidazole - 500 mg (three times a day).
use Features
In therapy should take into account that dairy products and the use of different drugs can slow the absorption of De-Nol. This is why drinking De Nol with omez be a period of time not less than 2:00. If Omez assigned once a day, then drink it in the morning, and De-Nol - day and night.
De-Nol in large doses can cause overdose effects matching the symptoms of kidney failure. For the treatment it is necessary to gastric lavage, and in severe overdose - to apply hemodialysis.
De-Nol is not synonymous omezThey are completely different drugs with different mechanisms of action. If necessary, replace the selected synonyms special medicines that have similar properties.
Conducting omez therapy may mask symptoms of cancer. Therefore, when frequent vomiting, severe weight loss, and other sudden and significant changes necessary to turn to a specialist and to conduct a survey.
Patients with malabsorption of cyanocobalamin should be administered cautiously Omez. Since this drug, as well as all drugs that block production of hydrochloric acid, break processes absorption of vitamin B12.
Before you take together Omez and De-Nol, you must make sure that there are no restrictions for both therapy drugs. Otherwise, the treatment can cause adverse side effects of symptoms, up to severe conditions.
Omez and De-Nol is not recommended to use the pregnant patients and breastfeeding women, as there is not enough reliable information on the conduct of clinical trials in this group patients. If necessary, if the benefit of treatment is greater than the risk for intrauterine growth retardation, the decision to use funds made by a physician.
conclusion
Omez and De-Nol used successfully for the treatment of ulcerative diseases of the digestive system in combination with each other. However, patients should be aware that replace De Nol omez impossible, because drugs have very different properties.
To disease therapy has been the most successful, Omez and De-Nol should be used simultaneously.
sources:
Vidal: https://www.vidal.ru/drugs/de-nol__6730
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = 7696368a-c3a6-4fd8-b73c-69a9af455d51 & t =
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