General information about rotavirus
rotavirus - a virus comprising RNA as the genome, tropic to the cells of the intestinal mucosa. Inside intestinal rotavirus is attached to the villi synthesize their own proteins, embedded in the human genome, is organic and functional disorders of the digestive system. We have a powerful capsule rotavirus, which helps him to pass through the acidic environment of the stomach and easily penetrate to the fibers.
Detect rotavirus can use the methods of laboratory diagnostics. Medical personnel conducts sampling feces, it then tested by ELISA, PCR. There are rapid tests for the detection of rotavirus and to determine its type.
Rotavirus rotavirus ( "intestinal flu"), which is characterized by the acute onset of symptoms such as:
- Pain in the stomach, intestine, associated with an inflammatory response of the authorities;
- Dyspeptic symptoms (nausea, single or multiple vomiting, bloating, rumbling);
- Intoxication syndrome in the form of weakness, fever, loss of appetite and sleep;
- Diarrhea (diarrhea);
- Malabsorption, lack of vitamins, trace elements and related manifestations.
In response to the penetration of rotavirus in the body with good immunity, a large amount of interferons, interleukins and cytokines, which will eventually destroy the virus. The body of the child protection system antiviral still not fully formed, so rotavirus often affects children and adults with weakened immune systems.
When rotavirus in adults taking Enterofuril possible only if it is known that, except rotavirus in the intestine is pathogenic bacteria, such as staphylococci, streptococci, enterobacteria. If the disease is caused only by a viral infection, Enterofuril not use. In such situations expedient receiving antiviral drugs, interferon and antibodies that are effective against rotavirus.
General information about Enterofurile
Enterofuril - an antibacterial drug used in pediatrics and therapies for the treatment of bacterial infections. Of rotavirus infection in children drinking Enterofuril not necessary, since the drug is ineffective against viral agents, including those against rotavirus. Taking non-prescription medicament, can be formed flora resistance to drugs.
Enterofuril discharged pharmaceutical company "Bosnalek" in Bosnia and Herzegovina and is marketed as an antimicrobial agent with a broad spectrum of activity against bacteria. Manufactured dosage forms: capsules at a dosage of the active substance 100 mg and 200 mg oral suspension. The suspension Enterofuril convenient for use in children under 3 years of age who still can not swallow capsules.
Enterofuril active components act on the intestinal level, preventing the growth, development and reproduction of microbes. Pharmacokinetic parameters are related to the chemical structure Enterofuril. Upon receiving the capsule or suspension per os drug enters the gastrointestinal tract. The effectiveness of the drug in the lumen of the intestine is provided by the fact that the active substances are not absorbed in the villi, and begin to act right here. Output drug substance also intestine. The liver is not involved in the elimination of metabolites Enterofuril that eliminates the burden on hepatocytes.
Upon receiving Enterofuril in children and adults may experience undesirable side reactions: allergic manifestations in as rash, urticaria, subcutaneous tissue edema, angioedema with stenosis of larynx, anaphylactic and anaphylactoid shock. However, the side effects occur very rarely and only in predisposed individuals. If unreasonably treat rotavirus Enterofurilom, the likelihood of adverse reactions may increase.
Enterofuril does not violate the normal intestinal biocenosis. The nature and amount of beneficial microflora after ingestion of the antibiotic is not disturbed. After treatment Enterofurilom not require preventive and curative receiving probiotics and prebiotics, which is often needed when taking other antibiotics.
Rational use of antibiotics
Enterofuril rotavirus take inappropriate, especially for the prevention of. Such use of an antibiotic is contrary to all the rules of the destination of this category of drugs.
The basic rules of appointment of antibacterial drugs:
- An antibiotic prescribed by the doctor. Self-appointed contraindicated, since each drug active against certain microorganisms. To find out which microbe was the cause of an infectious disease, it is necessary to pass the microbiological laboratory study (true for rotavirus);
- Strict adherence to dosage and duration of therapy. If you feel better, it does not mean that all microbes have left the body. In premature discontinuation of tablets, infection may return;
- For the purpose of the antibacterial agent should be strictly indications. viral pathologies Treatment with antibiotics is unacceptable;
- As a rule, during or after antibiotic treatment is necessary course of probiotics to restore normal intestinal microflora;
- If necessary prolonged antibiotic therapy, the drug is replaced every 7 days to prevent the formation of drug resistance.
Drug resistance - a major problem in modern medicine. The synthesis of new antibiotics occurs within a few years. Sometimes during this time strains of bacteria have formed resistance due to irrational use, and new drugs are not effective in the first stage of introduction into medical practice. A person who has strains of microorganisms resistant to the drugs, there are fewer medications that can help him.
In addition, an antibiotic to treat such resistant flora have many side effects and adverse symptoms are accompanied during therapy. All this makes it necessary to educate the public the basics of rational antibiotic therapy. The most important rule - do not use antibiotics for viral infections. Appointment possible if, in addition to the virus in the body, there are pathogenic bacteria that cause disease.
special cases
Enterofuril child with rotavirus can be assigned if the microscopic and bacteriological examination was It revealed the presence of salmonella in the intestine, Shigella, enterobacteria vibrios suppurative streptococcus, staphylococcus. Such a course of the disease is possible with a chronic bacterial infection of the gastrointestinal tract and the accession of acute inflammation caused by rotavirus.
In such a situation Enterofuril drink with rotavirus 2 or 3 times a day depending on the age. From the first months of life, give half a spoon of the suspension twice a day. With half a medication can be taken 3 times a day. Kids from the age of three can drink capsule Enterofuril. The recommended dose of suspension - 5 ml thrice daily, capsules - 200 mg 3 times a day. Babies with 7 years dosage can be increased to 800 mg daily (200 mg in 4 divided doses). The duration of treatment Enterofurilom with rotavirus and bacterial intestinal disease - no more than 7 days.
There is no information on overdose Enterofuril with rotavirus and concurrent bacterial infection. Pharmacokinetic parameters of the drug provides its effect only on the level of the intestine. The active substances are not absorbed in the walls of the gastrointestinal tract and does not penetrate into the systemic circulation. This also reduces the load on the liver and kidneys, making it the drug of choice for Enterofuril the treatment of infections caused by both rotavirus and bacteria in patients with severe liver disease and kidney.
Before the appointment Enterofuril with rotavirus and concomitant bacterial infection is necessary to exclude contraindications:
- Allergic reactions on derivatives nitrofuran a history of hypersensitivity to Enterofuril components;
- Child's age 1 month, prematurity, low birth weight, immaturity, birth pathology;
- Fructose intolerance, galactose, glucose-galactose malabsorption.
conclusion
Enterofuril when rotavirus is not used. The exception is secondary infection with rotavirus at already existing chronic bacterial enteritis or gastritis. Enterofuril - drug of choice in intestinal bacterial infections, as the medicament is not absorbed in villi misses the systemic circulation, has few side effects and is well tolerated by both adults and children. Against Rotavirus effective antiviral agents and interferons.
sources:
Vidal: https://www.vidal.ru/drugs/enterofuryl__2734
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = 9c80dbb9-89f9-4129-bbb9-dfdafb9989e7 & t =
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