Ferritin blood test. Which means reduced, increased among women, the rate, causes and treatment, pregnancy

Ferritin in the composition of the blood test, which is held in the normal range, means that the person does not suffer from iron deficiency and there is no risk of developing anemia. Reducing the level of ferritin indicates a change in the biochemical composition of blood and the possible presence of associated diseases, endocrine, hematopoietic, digestive system.

Functions in the body

Ferritin - a protein complex compound, which belongs to the category zhelezoproteinov. Performs physiological role of intracellular accumulation of capsules for iron atoms. Is a part of almost all the soft tissues, also acts as a permanent iron donor.

In 2001 he was first opened ferritin, which is localized in the mitochondria of cells. According to recent research, in one molecule of the protein compound contains at least 4000 iron atoms.

The main functions of ferritin in the body of men and women are its next destination:

• ensuring constant supply of iron atoms;
• Compensation iron deficiency substances under poor nutrition;
• saturation of blood with additional iron atoms to prevent decrease in hemoglobin levels in the blood;
• maintaining stable molecular oxygen transport function of blood cells;
• indication of the imminent development of iron deficiency anemia (before it starts decline in the level of hemoglobin in the blood, It starts to gradually decrease the concentration of ferritin, which indicates the active use of buffer stocks organism gland).

Ferritin in blood test - are protein compound, a sufficient number of which means that the functioning of the body is carried out in a stable manner without the risk of iron deficiency state. The structure of the substance is the compound of the protein apoferritin, iron atom (trivalent), and a phosphate hydroxide.

How and under what conditions it is produced

Formation of protein ferritin compounds - is a complex biochemical process that involves digestive, hematopoietic, respiratory and renal system. There are two major mechanisms of synthesis of the substance in men, women and children.

Anabolic

A man leads a normal life, eating food. The food which enters the intestine, absorbed into its walls, iron atoms identified as a separate fraction and together with the blood flow diverted to the soft tissues of the body. The presence of high-quality diet ensures stable maintenance of ferritin in the human body.

catastatic

This method of synthesizing a protein compound consists in extracting iron atoms with erythrocytes exposed gemolizatsii. This blood cells, which are a result of natural physiological processes have been destroyed, but before them excretion in the urine, the body returns iron atoms using them to ensure the provision of useful substances.

This ferritin formation mechanism makes it impossible to accumulate a sufficient amount of iron. Yet the bulk of the atoms of the substance is supplied together with food. A prerequisite the formation of a complex protein complex - ferritin is stable and sufficient supply of oxygen. only divalent iron is supplied together with the food into the human body.

Under the influence of oxygen occurs biochemical reaction of oxidation with the synthesis of a sufficient amount of trivalent iron, a component of ferritin. The lack of air conditions, prolonged hypoxia, the body produces SH-ferritin, which has toxic and paralytic effect.

Table indicator OK

Ferritin (blood analysis indicates that the level of iron-containing protein is normal, decreased or increased) - are protein compound whose concentration depends on many factors. Table optimum performance for children, men and women of different age groups as follows.

Age and gender identity	Indicators in the blood of ferritin
Newborn babies in the first 2 months. life	At this stage of physiological development of the highest rates of protein compounds in the blood serum. Ferritin concentration can reach 600 mg / l, which is the norm.
Children aged 2 to 6 months.	The optimum concentration of the protein compound is from 55 to 210 g / l.
Boys and girls under the age of 15 years	Ferritin level indicators characterized by the retention of stable and can range from 8 to 140 g / l, which is outside the norm.
Boys and girls under the age of 19 years	During this period of development of the organism concentration of protein compounds in the blood serum can reach 250 g / l.
Men and women of all ages	After puberty and entering into adulthood, ferritin levels remain stable. Its level is stored in the range of from 10 to 125 g / l.

For women who are pregnant, the best indicators of the level of ferritin in the blood is as follows:

• 1 trimester of fetal development - 50% of the optimal performance of a woman who bears a child is not;
• 2 trimester - about 30% from the above figures;
• 3 trimester fetal development - is not less than 12% of the specified concentration.

Ferritin (blood test means that the concentration of iron in the body is normal, increased or decreased) - is a proteinaceous compound, which can vary depending on factors such as diet, physical activity level, hormonal background, concomitant diseases.

Symptoms of increase and decrease

Increasing the concentration of ferritin in blood serum can be shown the following symptoms:

• pain in the muscles of the lower extremities;
• digestive disorders;
• too high a level of hemoglobin;
• heart palpitations;
• high blood pressure;
• change the level of red blood cells in the direction of increasing their numerical concentration;
• lack of appetite;
• too thick blood, and increase in platelet count.

Changes in blood levels of ferritin in the direction of incidence of its concentration exhibits the following symptoms and health problems:

• dizziness and migraine attacks;
• shortness of breath and feeling short of breath;
• physical weakness, drowsiness and fatigue;
• pale skin and mucous membranes;
• sleep disturbance.

Reducing the concentration of ferritin in the blood associated with the development of such diseases, such as iron deficiency anemia. Rapidly falling hemoglobin levels, impaired cellular composition of the blood in the direction of downsizing the number of red blood cells.

The reasons for increases and decreases

Increased serum ferritin may be due to the presence of the following diseases and pathological reasons:

• hereditary hemochromatosis type, as a result of which the intestinal wall is absorbed too much iron (mineral saturates visceral tissues, causing them damage and multiple internal bleeding);
• long reception of drugs in the composition which contains ferrous iron;
• acute and chronic liver disease associated with destruction of the body structure (cirrhosis, viral hepatitis or intoxication etiology, oncology);
• overactive thyroid tissue directed to the increased synthesis of hormones;
• hemolytic anemia type, which is caused by systematic destruction of erythrocytes;
• malignant bone marrow tumors;
• breast cancer in women;
• severe respiratory tract infections, and urogenital system (developed severe immune reaction that leads to a rapid increase in ferritin levels in the blood);
• malignant tumors of lymphoid tissues (Hodgkin's disease);
• alcoholism;
• too frequent blood transfusions in the course of which the disturbed physiological balance of red and white blood cells.

The gradual or rapid decline in blood ferritin is much rarer and can be caused by:

• Comorbidity as iron deficiency anemia;
• offensive third trimester of pregnancy;
• latent iron deficiency;
• dysfunction of the digestive system, as a result of which the process of assimilation of nutrients is broken;
• poor nutrition, diet, limiting the use of most of the products;
• internal bleeding that are dormant (found in peptic ulcer disease, oncology viscera closed injuries discontinuities main vessel walls).

Ferritin (blood test means that the human body provided with a sufficient amount of iron or the test its chronic deficit) - a protein complex that acts as an indicator of the biochemical composition blood.

For stabilization concentrations of the substance necessary to eliminate the reasons that provoke increase or decrease in the provision of iron in the connective tissue and the internal organs.

Indications for study

A blood test on the ferritin level is shown in the event that a patient to seek medical help, the following symptoms and clinical manifestations of a disease state of an organism:

• fast fatiguability;
• shortness of breath while walking away, feeling short of breath;
• prolonged fasting;
• deficiency of red blood cells;
• dizziness, lowering blood pressure;
• muscle pain and physical weakness;
• inability to concentrate;
• fall in hemoglobin in blood, which has been detected by the results of a clinical blood test.

Only a doctor should decide on the need to analyze the concentration of ferritin. An imbalance of this protein is a precursor of the compound changes the composition of biochemical blood, increase or decrease in hemoglobin concentration, red blood cells.

How to determine the

Ferritin (blood test means that the level of iron in the soft tissues of the body is in the normal range) - is a protein complex, which is the concentration can be determined by carrying out the following diagnostic procedures:

• Deposit of capillary blood from the beams of the ring finger for its clinical trial;
• collection of venous blood for analysis of biochemical composition.

  

The biological material is transferred into a sterile lab conditions, which experts carry out chemical reactions, aimed at determining the ferritin in the blood serum.

As the reagent used or cadmium sulfate method to influence the biological material chemical "Prussian Blue". According to the results of the chemical reaction are detected iron oxide salts (trivalent), or the compound is absent.

Specialist biochemical laboratory performs calculation of the mass of the substance and form an opinion on the quantitative composition of ferritin.

Preparation and analysis

Before you take the tests to determine the level of the protein complex in the tissues of the body, you must perform a number of preparatory procedures.

they are as following:

• biological material must be treated only on an empty stomach;
• the last meal should take place no later than 8 hours before the sampling of venous blood;
• for 1 h before delivery of venous blood is necessary to drink 250 ml of warm water to which was added 1 h. l. sugars (this liquid is to provide the body necessary amount of glucose and facilitate feeling at the time of venous blood sampling on an empty stomach);
• 3 days prior to visiting the laboratory must stop taking all drugs, the composition containing active substances based on iron (ferric or two);
• 30 min. before delivery of the venous blood should be avoided psycho-emotional surge, as well as strenuous exercise, so as not to cause destruction of red blood cells;
• 72 hours before the scheduled date of the study is forbidden to drink alcohol and drugs.

Determination of ferritin concentration should be carried out in conjunction with other diagnostics. For example, biochemical and clinical blood tests. In the case of concomitant diseases of internal organs, shown MRI and diagnostic ultrasound.

Decoding results

The process of interpretation of the results of diagnostic studies are performed by the attending physician, who was initially appointed analyzes the change. To perform these actions on their own, you must take the laboratory opinion on qualitative and quantitative composition of the blood, as well as the concentration of ferritin in it, and then compare with performance standards.

They are all listed in the table above. Reduction of protein compounds indicates iron deficiency in an organism, poor diet, or the presence of internal bleeding.

High ferritin level also indicates a pathological state of blood and hematopoietic system. More detailed decoding and establishing the causes of the change in the level of protein compounds in the blood, should be carried out in a health institution.

When to see a doctor

Appeal to the clinic to be held no later than the next day after a man found in his symptoms suggestive of an increase or decrease in ferritin levels. Examination and treatment of this disease has been haematologist.

In health care facilities, which are not equipped with a specialist of this profile, the duties for the diagnosis and treatment of patients in this category are assigned to the general practitioner. It is delaying the visit to the doctor fraught deterioration of general health, development of anemia or increasing the level of hemoglobin.

How to bring back to normal

Restoration of blood ferritin level involves the use of medication therapy, traditional recipes and dietary compliance.

Medications

The use of drugs is only advisable if the task is to increase zhelezoproteina concentration in the blood.

In this case, the following tools are used:

• Fersinol-3 - a preparation containing in its composition the ferrous iron, vitamin B complex, ascorbic acid, 1-2 taken along the capsule 1 once a day before normalization ferritin levels (medicament value - 575 rub.);
• Medefer - Contains in its composition the active substance iron fumarate, take 1-2 capsules daily after meals with Drinking enough fluid therapy period is determined individually (the price of the product - 350 rub.);
• Sorbifer Durules - complex preparation which contains in its composition ferrous sulfate and ascorbic acid, is assigned to reception of 1 tablet 2 times a day for 30 minutes. before meals with a course of treatment up to 4 months. (Medication cost - 300 rbl.);
• Ferroplekt - therapeutic effect is achieved due to the active components of ferrous sulfate heptahydrate and ascorbic acid, take medication for 1-2 tablets 3 times a day after 2 hours after a meal (a course of treatment up to 6 months., and the cost of the drug 330 rub.).

The above-mentioned drugs should be prescribed only by a doctor, a hematologist or physician as a result of a diagnostic blood test.

Traditional methods

In addition to medication therapy, the following recipes of traditional medicine, which helps to stabilize the level of ferritin in the body.

dining room beet juice

You need to collect 2-3 root beet red dining room, finely chop them, and then squeeze the juice from them. Take it to 1 tablespoon. l. 3 times a day for 15 minutes. before meals. Duration of treatment up to 4 months.

Cranberries, walnuts and honey

This nutrient mixture that is rich in B vitamins, ascorbic acid, ferrous iron. For its preparation must take 150 g fresh cranberries, shelled walnuts and honey. All the components are mixed thoroughly and take 2 tbsp. l. 3 times a day after meals. The course of treatment is from 1 to 2 months.

Water extract

Should take for 1 h. l. such herbs as chamomile, St. John's wort, nettle, blackberry leaves. Then they poured into the thermos, to which is added 1 liter of boiling water. The future of drug infused over the next 4 hours. After this time, it adopted a means of 100 ml in the morning and evening for 30 min. before meals.

carrot juice

In the composition of this vegetable contains large amounts of iron, vitamin A, and ascorbic acid. To increase ferritin levels in the blood should be taken about 5 root vegetables, squeeze juice from them and take it 3 times a day for 1 st. l. for 20 min. before meals. The length of treatment time is not limited, and may be from 1 to 6 months.

Other methods

In combination with the use of traditional medicines and drugs that can be purchased at the pharmacy, observe the rules of diet.

At low rates of ferritin diet is saturated with the following food:

• Ocean Fish;
• beef;
• walnuts, peanuts, sesame seeds;
• milk;
• hematogen;
• buckwheat;
• green apples;
• dining room beet;
• strawberries, blackberries, strawberries, cranberries, cranberry;
• carrot;
• compote on the basis of wild rose;
• honey;
• citrus;
• meat nutria, rabbit, turkey.

At too high a level of ferritin in the blood above the use of food is limited. It is very important that the true cause violations of iron-containing protein level has been established.

possible complications

Lack of timely treatment to the doctor, malformed therapy, may lead to the development of these complications and negative effects:

• the occurrence of iron deficiency anemia;
• destruction of red blood cells;
• hypoxia of the brain tissue caused by a critical decrease in hemoglobin levels;
• reduced mental activity;
• the development of chronic fatigue syndrome;
• fatigue and partial disability;
• decreased immunity;
• cardiac arrhythmia.

Violation of the best indicators of ferritin in the blood indicates the presence of concomitant diseases of the blood, blood-forming system, the digestive tract.

Reducing the level of ferritin is displayed in the test results indicate a systemic lack of iron in the body, as well as the imminent risk of anemia. Needless protein compound serves as a drive-up quantity of a mineral that accumulates in soft tissues and internal organs.

Registration of the article: Vladimir the Great

Video on the analysis on ferritin

Komorowski of "iron" assays: