- 1 Isofra - release form and composition
- 2 Mechanism of action and indications for use
- 3 Isofra Spray for children
- 4 Contraindications and side effects
- 5 Average prices and analogues
- 6 Application Reviews
This article will be considered in detail instructions for use Isofra, as well as drug analogues. Izofra antibacterial drug is used in ENT practice in the treatment of inflammatory processes of the nasopharynx, frontal and maxillary sinuses.
When our body attacks an infection, it is the upper airways that take the first blow. Discomfort and discomfort can and should be removed with the help of special tools. Isofra is one of the most popular and effective drugs for the treatment of various types of rhinitis, and can be used by both adults and children.
Isofra - release form and composition
The drug is currently available only in the form of a nasal spray. Isofra Drops is a non-existent drug that is not represented on the pharmaceutical market. The release of this form of the drug containing an antibiotic is not advisable due to dosage errors. Therefore, on the pharmacy stalls, you can only find a spray in a 15 ml vial.
The main active ingredient of the drug is framacetin sulfate. Its concentration is 12.5 mg per 1 ml spray. Sodium chloride, citric acid, methyl para-hydroxybenzoate and distilled water are present as auxiliary substances in the solution. In addition to the medicine bottle, the carton pack contains a spray nozzle and instructions for use. Isofra shelf life after opening the bottle is 1 month, before opening - 1.5 years.
Mechanism of action and indications for use
Isofra nasal spray has a bactericidal effect and destroys a number of pathogenic microorganisms. Framycetin molecule is able to inhibit protein synthesis at the level of ribosomes, penetrating the cell through the membrane. When applied topically, the drug has a detrimental effect on gram-positive and gram-negative bacteria, streptococci, staphylococci, facultative anaerobes and enterobacteria.
Isofra spray is prescribed as part of the complex treatment of infectious and inflammatory processes of the upper respiratory tract:
- infectious rhinitis;
- bacterial sinusitis;
- sinusitis without signs of damage to the septum;
- non-allergic rhinitis.
Also spray is used as a prophylactic to prevent complications after surgery. Practice shows that Izofra spray effectively copes with nasal congestion in third-degree adenoids. It is worth noting that the drug is not used in the defeat of the nasopharynx viruses and is not used in the treatment of SARS or influenza.
Isofra spray for children
According to the instructions for use, this drug is approved for use for children older than 1 year. However, some clinical studies have shown that the drug is safe and can be used for newborn babies. The effectiveness of the spray in treating infants older than one month has been confirmed. At the same time, it must be remembered that Isofra spray for children is prescribed only by the attending physician. Independent use of the drug in this case is unacceptable.
Good to know
Most often, children are prescribed medication for prolonged rhinitis and purulent nasal discharge. Isofra in the ears can be used in the treatment of otitis media (inflammation of the middle ear).
Despite the rather comprehensive information contained in the instructions for the spray, the specific treatment regimen is determined by the pediatrician. At the same time, there are several basic nuances and rules that must be followed during the treatment of rhinitis in children with Isofra:
- The duration of the course of treatment should not be more than 10 days. As a rule, on the third day after using the Isofra spray, there is a positive trend. If symptoms persist, you should inform your doctor. Most likely, you will have to change the treatment regimen.
- A single dose of the drug is injected into each nasal passage at a time. One click on the nebulizer is enough to completely distribute the drug on the surface of the nasopharynx.
- Frequency of use should not exceed 3 times a day.
- Before using the drug, you must clean the nasal passages of the baby. To enter the drug, simply attach its tip to the nostril. No need to put it inside.
The use of such a spray ensures maximum safety during the treatment process. The sprayed substance is better distributed over the affected mucous surface and does not enter the baby’s stomach. The main component - framycetin has low bioavailability and is practically not absorbed into the bloodstream. Thus, local application of the drug does not provoke complications of a nephro- and ototoxic nature.
Isofra spray for adults
The monocomponent preparation Isofrav nose is also used to treat adult patients with inflammatory processes in the sinuses and the eustachian tubes. The daily dosage for this category of patients is from 4 to 6 injections per day in each nostril. In order to avoid the addition of fungal diseases and dysbiosis of the mucous membrane, the duration of the course of treatment should be no more than 10 days.
Whether Isofra is possible for pregnant women is an actual question that patients in a position are often asked to their attending physician. Despite the fact that the spray from the nephro-vestibulotoxicity is extremely low, and the active substance of the drug hardly penetrates into the systemic circulation, it is contraindicated in pregnancy. All drugs aminoglycoside type, getting into the mother's blood, adversely affect the developing fetus. Among the consequences of the use of spray during pregnancy can be noted the possible development of bilateral deafness in a child.
During lactation, the use of this drug is also prohibited. Spray components can get into the body of a baby with breast milk. The use of the drug is possible only after transferring the baby to artificial mixtures. It is possible to resume breastfeeding only two weeks after the course of treatment.
Contraindications and side effects
This drug should not be used with individual intolerance to framycetin. Also, it is not prescribed for hypersensitivity to aminoglycoside drugs. Due to the lack of knowledge of the safety and efficacy of the drug in pregnant and lactating women, this category of patients is contraindicated. With extreme caution, framycetin preparations should be used for patients with the following pathologies:
- renal failure any origin;
- vestibular lesions;
- acquired hearing loss of any degree;
- taking cholinolytics, ganglioblokatorov, atropine and muscle relaxants.
Isofra spray is quite effective and safe. Therefore, in the absence of diseases of the kidneys and inner ear, the patient can safely use it within the recommended dosage.
Low systemic adsorption capacity of the drug virtually eliminates side effects. Patient reviews about the drug confirm the absence of such manifestations. If you are hypersensitive to medication components, allergic reactions may occur that occur. in the form of urticaria or rash all over the body, as well as signs of dysbiosis against the background of oppression of the mucous microflora the nose. Exceeding the recommended period of use can provoke a fungal infection.
Average prices and analogues
The price of the drug in Russia varies from 250 to 400 rubles. However, there are drugs similar in effect, which allows you to choose a cheaper, but no less effective medicine.
- Grippferon. Nose drops that have an antiseptic effect and quickly relieve the inflammatory process. The active ingredient in the preparation is recombinant human interferon. The cost of the drop is 200-250 rubles.
- Miramistin. It is used in the treatment of sinusitis, otitis and tonsillitis. Is a good alternative to Isofra. The price varies from 100-150 rubles.
- Nesopin. The active ingredient is oxymetazoline, which copes with sinusitis and otitis media. The price of the drug is 80 rubles.
- Rhinostop. Cheap Isofra analogue, which also has antibacterial properties, reduces inflammation and can be used to treat infections in the respiratory system. The cost of the drug - from 35 rubles.
- Framinazine. Cheap synonym Isofra, cost from 30 to 60 rubles. The drug contains in the antibiotic framinazin. You can take the drug to children under 6 years old and pregnant, but with caution and under the supervision of a physician.
Polydex. Unlike Isofra, it contains two antibiotics at once, which expands the spectrum of the drug's action. Each of the components acts on a specific group of pathogenic microorganisms, which allows us to achieve a more pronounced therapeutic effect. The tool is available in the form of a nasal spray and ear drops. Due to the high aggressiveness of the components of Polydex, it can be used only for children from 2.5 years. The average price is 300-350 rubles.
It should be noted that only a qualified doctor should determine analogs for the replacement of Isofra. It is the specialist who can select the most suitable drug, taking into account the symptoms and the general condition of the patient.
Review number 1
The younger son suffered from a cold for more than two weeks. In the first week I thought that it would pass and nothing terrible, but when the symptom was delayed, I realized that I needed to do something. Frightened also purulent nasal discharge of green. Swelling of the nasal mucosa did not pass, the son could not breathe normally at night.
Tried various means: antispasmodic drops, sprays - nothing helped. At the doctor's appointment, we were prescribed Isofra spray. For a bottle of 15 ml paid 250 rubles. According to the instructions, the spray was administered three times a day, one injection into each nostril. The very next day, from the beginning of the application, there was less discharge from the nose, breathing with the nose was freer. By the third day, the discharge became transparent, and on the fifth day the rhinitis passed completely.
Review number 2
Six months ago, the child had a cold, or rather a runny nose. All the other symptoms went rather quickly, but there was a problem with the nose. At first there was a clear discharge, and then they became thick, viscous and greenish. Nothing helped, and I had to go to the doctor.
Then met with the spray Izofra. What is embarrassing is that it is an antibiotic, and I always treat with caution the use of such drugs, especially when it concerns a child. But the pediatrician convinced me of the effectiveness and necessity of its use. The very next day after use, the child's condition improved. Nasal discharge became less abundant and transparent. After three days, this unpleasant symptom disappeared altogether.
Review number 3
I think almost everyone, even the easiest cold does not go away without a cold. But it can also be different: sometimes it is quite easy to cure it, and sometimes it goes into a protracted stage. It used to cope with this symptom with various drops and sprays such as Otrivin. But the last time, when the runny nose was delayed and was accompanied by severe congestion and thick purulent secretions, I had to use other drugs.
The doctor advised to use an antibiotic for topical application of Isofra. I first heard about him, read reviews, and decided to follow the recommendations of a specialist. Despite the fact that it is an antibacterial agent, it does not enter the bloodstream, but acts only on the surface of the nasopharynx. Before use, she was flushing her nose, and every day she injected 4 times one dose into each nostril. Three days later, the runny nose was completely gone. The tool is quite expensive - bought for 370 rubles, but one bottle is enough for several course treatments.
Ekaterina, Nizhny Novgorod