Miscellaneous

Nimesil: instructions for use as a plant powder?

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Nimesil refers to the group of nonsteroidal anti-inflammatory drugs.

It has pronounced analgesic properties. It is used to remove the body of pathological inflammatory processes, eliminate concomitant pain.

Composition, structure

Nimesil drug in the dosage form produced powder to prepare a slurry, which is intended for ingestion. It has a light green color, large grain and orange scent. The main active component of the medicament is nimesulide, its content in 1 sachet of powder is 100 mg. Also, the drug contains additional compounds, which include:

  • Sucrose.
  • Orange flavoring.
  • Ketomakrogol.
  • Anhydrous citric acid.
  • Maltodextrin.

Nimesil powder is packed in bags of aluminum foil for 2 years The cardboard pack contains 9, 15 or 30 packets.

pharmachologic effect

The main active ingredient nimesulide nimesil acts related sulfonamides. This substance inhibits the body cyclooxygenase-2 activity, the enzyme responsible for prostaglandin production, which are synthesized in the development of pathological processes. Reducing the amount of prostaglandins synthesized as a result of exposure to nimeslina helps reduce irritation of nerve endings in the area of ​​inflammation, which in turn leads to the disappearance of pain sensations.

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After ingestion of the drug begins to be active. It is easily absorbed from the stomach and intestines, into the blood, binding to plasma proteins. The largest amount of active substance in the blood observed after about 2-3 hours after drug administration. Major metabolic processes occur in the liver, but appeared inactive products are displayed for 6 hours (half-life).

According to the research, re-taking the drug to cause accumulation.

Indications nimesil

Nimesil prescribed for:

  • pain syndromes of different origin (headache, toothache, menstrual pain, injuries consequence, postoperative pain, pain from rheumatism et al.);
  • infectious inflammatory diseases (traumatic and postoperative inflammation)
  • degerativnye and inflammatory diseases of the musculoskeletal system (arthritis, osteoarthrosis, osteochondrosis, bursitis, sciatica, rheumatism et al.);
  • urological, gynecological and vascular diseases;
  • diseases accompanied by fever.

This is appropriate as a means during prolonged treatment therapy and for blunting strong pain syndromes.

Contraindications

Before taking medication, you need to eat through these contraindications manufacturer. In particular, do not take it in these situations:

  • Hypersensitivity to the current basis (nimesulide) or the support component of the drug.
  • Hyperergic organism's reaction history: rhinitis, urticaria, bronchospasm, laryngospasm associated with taking of any drug from the NSAID group, including nimesulide.
  • Hepatotoxic reactions to nimesulide history.
  • Simultaneous treatment with other drugs having hepatotoxic action (especially from the group NPPS).
  • Inflammatory processes in the intestine in an exacerbation phase (b-Hb Crohn's disease, ulcerative colitis).
  • The recovery period after coronary artery bypass surgery.
  • Fever that accompanies colds and SARS.
  • The combination of asthma, polyposis, paranasal sinuses or nasal passage and with recurrent history of intolerance to NSAID;
  • Aggravation of gastric ulcer and 12 duodenal ulcer;
  • Ulcer bleeding or perforation in history;
  • Cerebrovascular or other bleeding in history;
  • Diseases accompanied by bleeding;
  • Clotting heavy nature of blood;
  • Severe heart failure;
  • Renal failure in severe;
  • Confirmed by hyperkalemia;
  • liver disease in the acute phase;
  • Liver failure;
  • Children up to 12 years;
  • Pregnancy, lactation;
  • Drug addiction, alcoholism.

Be wary appointed in the following pathologies and factors:

  • heart failure of any degree;
  • hypertension severe;
  • type 2 diabetes;
  • coronary artery disease;
  • hereditary fructose intolerance;
  • glucose-galactose malabsorption;
  • failure-isomaltose sucrose;
  • dys- or hyperlipidemia;
  • cerebrovascular disease;
  • severe somatic diseases;
  • arterial disease (peripheral);
  • an infection caused by Helicobacter pylori;
  • creatinine clearance less than 60 mL / min;
  • prolonged treatment with NSAIDs;
  • elderly age;
  • smoking.

Side effects

Before using the medication, it is important to familiarize yourself with the manufacturer submitted a list of possible side effects:

  • increasing potassium levels in the blood;
  • light the general weakness, decrease in body temperature;
  • anemia, thrombocytopenia;
  • problems with urination, renal failure;
  • sweating, various character skin rash, dermatitis, erythema, nephrotic edema;
  • disrupt the normal functioning of the liver (in particular - the synthesis of certain enzymes);
  • headache and dizziness, irrational crystals, lethargy, drowsiness;
  • blurred vision;
  • shortness of breath, cough;
  • disruption of the digestive tract, the occurrence of bleeding, ulcers;
  • pressure.

To reduce the chance of side effects, the right thing would be to minimize the dose of medication received, and to minimize the duration of the course of treatment it.

How to plant powder Nimesil - instructions for use

According to the instructions, Nimesil powder for suspension, which is taken orally.

One packet is dissolved in 1 cup of water volume of 100 ml. The prepared suspension should be used immediately, it can not be stored. The average therapeutic dose is 100 mg of nimesulide (1 packet), 2 times per day.

The maximum duration of therapy Nimesil powder must not exceed 15 days. Correction of dosage for adolescents older than 12 years, the elderly, and patients with concomitant non-severe renal insufficiency is usually not required.

Overdose

Symptoms of overdose are: drowsiness, lethargy, nausea and vomiting, pain in the epigastric region, may develop gastrointestinal bleeding. In rare cases, there is an increase in blood pressure, develop acute renal failure, respiratory depression up to coma and develop other anaphylactoid reactions.

When time started symptomatic treatment of all phenomena are reversible.

Pregnancy and lactation

Nimesil it is forbidden to accept pregnant women, regardless of trimester. Likewise, it is not recommended to use the drug during lactation. If a woman is forced to take Nimesil, it should be on time to stop breastfeeding - up to complete elimination half-life of nimesulide products from the body.

drug interactions

The drug enhances the effect of drugs which are used to reduce blood clotting. Nimesil also can enhance the effect of furosemide. In simultaneous reception nimesil and methotrexate may worsen the side effects. Nimesulide is rapidly binds to plasma proteins, so the person being treated with sulfonamides and hydantoin should be under close medical supervision. The drug enhances the effects of cyclosporine on the kidney. If Nimesil used together with lithium preparations, the concentration of lithium in the plasma increase.

Treatment with nimesil requires caution when combined with drugs used him on the pressure, diuretics or other anti-inflammatory and analgesic medications.

special instructions

Nimesil for instructions if the patient has the risk of ulcers, gastrointestinal bleeding, as well as simultaneous treatment of the above preparations, Nimesilom therapy is started with the lowest dose, observing the state of patient. At the slightest adverse or undesirable reactions treatment ceased.

  1. As part nimesil there sucrose that should be considered in patients with diabetes: 1 sachet XE 0.15-0.18.
  2. In the event of SARS and the common cold events during therapy Nimesilom treatment ceased.
  3. Care must be taken during the treatment period Nimesilom when driving and accurate, hazardous work.

nimesil price

The average cost of a powder Nimesil package containing 30 bags in pharmacies in Moscow varies from 690-710 rubles.

analogs

Similar in composition, with the active ingredient nimesulide, are the following drugs: Nemuleks, Aktasulid, upon, Ameolin, Aulin, Nimesulide, nimulid, Sulaydin et al. Some of them have a fraction of the cost with the same efficiency with Nimesilom.

Unlike granules for suspension from tablets (cheaper) only in the fact that the effect is a little faster due to the more rapid absorption of the slurry, and the efficiency is the same.

Reviews of doctors and people

  1. Svetlana Kharkova dentist. Toothache is strong enough, and should not be tolerated. Admission nimesil can help the patient. Of course, it is very important to pay attention to the possible side effects and contraindications - medication can be taken not to all. In some cases, I recommend Nimesil for pain relief after treatment or tooth extraction. And I can say with confidence - for the long practice of no one complained that Nimesil did not help, or it was bad.
  2. Catherine Menshikov. Nimesil became for me a real salvation at a time when the treated teeth. The pain was unbearable, like a visit to the doctor, and the first few days after treatment (two teeth had to be removed due to inflammation). Plus, this medication is that it is easy to breed and very quickly starts to operate. Of course, there are cheaper counterparts - but do not want to experiment, because Nimesil been tested by time.

Storage conditions and shelf life

The drug may be stored in a dark, dry place. Temperature - not exceeding 25 C. In case of damage to the package integrity powder, it should be disposed without fail. The drug should be available for children.

Shelf-life of the drug is 2 years of the date of manufacture, (date indicated on the package). After completion of the period of validity can not take medicine.

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