Due to this, they effectively inhibit viral replication within the cells of the body, thus contributing to the speedy recovery from viral infections.
Release form and composition
Produced medicament in the form of tablets, each of which comprises:
- 60 mg or 125 mg tilorona (tilaksina);
- Such auxiliaries such as microcrystalline cellulose, croscarmellose sodium, povidone, potato starch, calcium stearate.
The film coating composition comprises Polysorbate, titanium dioxide, hypromellose, macrogol, colorants sikovit quinoline yellow and yellow-orange 85.
pharmachologic effect
Tirolon composed Amiksin tablets is a representative group lekartsvennyh pharmacological drugs - antivirals and inducers of endogenous interferon production. Interferon is one of the major biologically active compounds, which is produced by cells of the immune system and has a protective activity against viruses (interferon α), by suppressing the translation process (the construction of protein molecules) viral particles within the infected cells. After accumulating tirolona therapeutic concentration in the body, liver cells, colon, T-lymphocytes, granulocytes, after 4 chasa beginning to produce interferon. Due to stimulation of antiviral immunity and suppression of translation of viral proteins, Amiksin tablets are used for leche6niya various viral infections. He also has other biological effects that contribute to the strengthening of the functional activity of the immune system:
- Strengthening the production of antibodies by B-lymphocytes and plasma cells.
- The stimulation of stem cells in the bone marrow, which leads to an increase in immune cells in the blood.
- Optimization of the ratio of T-lymphocytes and B-lymphocytes to their maximum protective properties.
After receiving tablets Amiksin inwardly, the active ingredient is absorbed from the intestine into the blood. A therapeutic concentration in the body is achieved already after 30 minutes after administration. Tirolon freely penetrates into all tissues of the body, it passes through the blood-brain barrier, placenta (ingested by the growing fetus during pregnancy) and passes into breast milk during lactation. Excreted Amiksin active substance pellets excreted unchanged in the feces mostly (70%), partially in the urine (7%). The half-life (the time for which the output half of the drug concentration in the body) is 48 hours.
Indications Amiksina
As stated in the instructions to amiksin, adults, this antiviral drug is prescribed for the treatment of:
- SARS and influenza, as well as for prevention;
- Viral hepatitis A, B, C;
- Herpes infection;
- Cytomegalovirus infection;
- Viral and allergic encephalomyelitis, including uveoentsefalitov, leykoentsefalitov, multiple sclerosis (In the complex therapy);
- Respiratory and urogenital Chlamydia (such as one of the drugs combined treatment);
- Pulmonary tuberculosis (in the complex therapy).
Children older than 7 years Amiksin, according to instructions, is recommended for the treatment of influenza and acute respiratory viral infections.
Contraindications
According to the drug annotation applying Amiksina contraindicated:
- Pregnant women;
- During lactation;
- Children under 7 years of age;
- In the presence of hypersensitivity to any component of the medicament.
Dosing and Dosage Amiksina
Amiksin tablets should be taken orally after a meal.
The dosage for children is 60 mg once a day for the first, second and fourth day of treatment. The total course dose - 3 tablets of 60 mg. With the development of complications take medication at the same dose, similarly, plus an extra tablet on the sixth day of treatment, i.e., in total 240 mg (Table 4.).
Amiksina adult dose depends on the type of disease and evidence.
- For the purpose of prevention of influenza and SARS drug prescribed by Table 1. once a week for 6 weeks. The total dose - 6 Table. (750 mg).
- For the treatment of SARS and influenza Amiksin take on such a scheme: the first and second days of 125 mg once, then - 125 mg every other day. Total tablet - 6 pc.
- For nonspecific prevention of hepatitis A take one 125 mg tablet once a day for 6 weeks. Coursework dose - 6 Table.
- For the treatment of hepatitis A in the first day of taking 125 mg twice a day, Table 1 hereinafter. - every 48 hours. Heading dose - Table 10. Amiksin (1.25 g).
- In acute hepatitis B in the first two days take 1 tab, then -. A day. The total rate - 6 tablets (2 g) in a protracted course of the disease - Table 20. (2.5 g). Acute hepatitis C is treated similarly protracted hepatitis B.
- In the treatment of chronic hepatitis C in the first and second day, administered 250 mg per day, then - 125 mg a day. In total, this phase of treatment, the patient must take 20 tablets. Thereafter, it is transferred on reception of a preparation of one tablet 125 mg once every seven days for 20 weeks. Thus, all the patient must take 20 tablets Amiksin 125 mg for 6 months. During this period, regularly morphological, biochemical and immunological studies that reflect the degree of activity of the process, based on their results the doctor may adjust treatment regimen.
- In chronic hepatitis B in the first two days of receiving 250 mg, then - 125 mg a day. In continuation phase Amiksina dose of 125 mg once a week, total dose - 10 (1.25 g) and 20 (2.5 g) tablets. The total duration of treatment - from 3.5 to 6 months, depending on the results of immunological, biochemical and morphological studies, reflecting the degree of activity of the process.
- In the complex treatment of pulmonary tuberculosis Amiksin designate the following scheme: the first and second days of 250 mg per day, then - 125 mg every 48 hours. Heading dose - 20 tablets (2.5 g).
In all other cases, drug taking 125 mg in the first two days, followed by 1 tablet every 48 hours, and differs only in the length of treatment and the total number of tablets:
- In treatment of infections neyrovirusnyh - 10-15 Table .;
- When herpes and cytomegalovirus infections - 10-20 pcs .;
- Urogenital and respiratory chlamydia - 10 pcs.
Side effects Amiksina
Numerous reviews amiksin suggest that the antiviral drug predominantly most cases well tolerated and subject to the recommended dosage side effects are not a doctor provides. Occasionally patients complain of intermittent fever. Even more rarely, there are dyspeptic symptoms. In individual cases, possible allergic reactions due to hypersensitivity or intolerance of a component of the medicament.
Amiksina overdose cases in medical practice has not been registered, however, exceed the dose prescribed by the doctor is not recommended, since it is possible short-term depletion of immunocompetent cells.
Overdose
In case of a significant excess Amiksin dose tablets the therapeutic dosage developed symptoms characteristic of side effects. With an overdose of the drug is stopped. To clean the digestive system is carried out gastric lavage and bowel. If you must perform symptomatic and detoxification therapy.
special instructions
Application Amiksina can be combined with antibiotics and drugs intended for the traditional treatment of bacterial and viral infections.
analogs Amiksina
Structural analogs are Amiksina Lavomax, Tirolon, Tilaksin, tilorona.
As belonging to the same pharmacological group and the similarity of action counterparts Amiksina mechanisms can be considered the following drugs: Alpizarin, Arbidol, Viracept, hiporamin, Groprinosin, Kagocel, Nikavir, Panavir, and many Tselzentri others.
Prices for Amiksin
Amiksin tablets, film-coated 125 mg, 6 pcs. - from 550 rubles.
Terms and conditions of storage
Amiksin - drug list B. A medicament for children (60 mg) is released by prescription in tablet dosage of 125 mg - in OTC mode.
Shelf-life of the drug is 3 years, subject to the rules recommended by the manufacturer Storage - cool (at temperatures up to 30 ° C), dry and protected from direct sunlight a place.
