Sumamed: instructions for use, real prices

Sumamed antibiotic is designed for wide range of applications. The active ingredient - azalide - is representative of a new polgruppy makroidov. Active action occurs only when the amount of the concentrated drug within range.

In the active phase Sumamed inhibits protein synthesis processes formations microbes slows down the growth of bacteria, affects their proliferation. The drug is recommended to use in diseases caused by infections of the respiratory tract, various angina, sinusitis.

Release form and composition

The drug is produced in the following forms:

1. Tablets of 125 mg - biconcave, round, blue, film-coated. There engraving «PLIVA» and "125". The blister packed tablets 6.
2. Tablets of 500 mg - lenticular, oval, blue, film-coated. At the turn of white pills. There engraving «PLIVA» and "500". The blister packed tablets 3.
3. Gelatin capsules have a blue and blue housing cover inside the capsule - powder or mass having a white or light yellow. The blister contains 6 capsules.
4. The powder was used to prepare a suspension Sumamed, it has a white or light yellow. He granular, with the aroma of banana and cherry. Powder prepared homogeneous suspension. Contained in vials of 50 ml, the kit includes a measuring spoon or syringe for dosing.
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The preparation includes all forms of the active ingredient azithromycin dihydrate.

pharmacodynamics

It has a broad spectrum of antimicrobial action.

It is active against a number of Gram-positive bacteria: Streptococcus pneumoniae, S. pyogenes, S. agalactiae, S. viridans, Streptococcus group C, F and G, Staphylococcus aureus, S. epidermidis. He has an effect on gram-positive bacteria resistant to erythromycin. Effective against gram-negative organisms: Haemophilus influenzae, H. parainfluenzae and N. ducreyi, Moraxella catarrhalis, Bordetella pertussis and B. parapertussis, Neisseria gonorrhoeae and N. meningitidis, Brucella melitensis, Helicobacter pylori, Gardnerella vaginalis.

It acts on the sensitive anaerobic bacteria: Clostridium spp, Peptostreptococcus spp, Peptococcus spp... In addition, effective against intracellular and other microorganisms, including.: Legionella pneumophila, Chlamydia trachomatis and C. pneumoniae, Mycoplasma pneumoniae, Ureaplasma urealyticum, Listeria monocitogenes, Borrelia burgdorferi, Treponema pallidum, Campylobacter jejuni, Micobacteria avium complex.

Indications

Indications for use of Sumamed is infectious and inflammatory diseases caused by susceptible to malaria infections:

• lower respiratory tract infections (acute bronchitis, exacerbation of chronic bronchitis, pneumonia, including caused by atypical pathogens);
• infections of the upper respiratory tract and ENT (pharyngitis / tonsillitis, sinusitis, otitis media);
• initial stage of Lyme disease (borreliosis) - erythema migrans (erythema migrans);
• skin and soft tissue infections (erysipelas, impetigo, secondarily infected dermatoses, acne vulgaris moderate severity (for tablets));
• urinary tract infections (urethritis, cervicitis) caused by Chlamydia trachomatis (for tablets and capsules).

Contraindications

Refrain from appointing under such circumstances:

1. Creatinine clearance less than 40 mL / min;
2. Admission ergotamine, dihydroergotamine;
3. Allergies to the ingredients;
4. Severe renal pathology (class 6 for Child-UR);
5. Patients 12 years weighing less than 45 kg - for tablets and 500 mg capsules; up to 3 years - for the table. 125 mg up to 6 months. - any form).

Accept, but with warnings when specific to the symptoms:

1. Elongated interval QT;
2. When entering antiarrhythmic agents (quinidine, procainamide, dofetililida, amiodarone, sotalol);
3. Myasthenic symptomatology;
4. Moderate renal dysfunctions and with a creatinine clearance greater than 40 mL / min;
5. Proaritmogennoe manifestations;
6. When receiving tsizapridoma, terfenadine;
7. Metabolic disorders, hypokalemia, hypomagnesemia;
8. Clinical bradycardia, arrhythmia, severe heart failure;
9. Use of antidepressants (citalopram), antipsychotics (pimozide);
10. Admission fluoroquinolones;
11. Treatment with digoxin, warfarin, cyclosporine.

Pregnancy and breastfeeding

If the expected benefit of the drug is higher than the possible danger to the fetus, according to a doctor's prescription can be used Sumamed. Breast-feeding during this period is suspended. WHO admits azithromycin, as the antibiotic for treatment for chlamydial infection in pregnant women.

Side effect

Side effects occur infrequently and rarely, except for a few. The body can be affected by such disorders:

1. Nervous system: often - headache; rarely - paresthesia, taste disturbance, drowsiness, nervousness, dizziness, insomnia; seldom - agitation; frequency is unknown - the loss or distortion of smell, loss of taste, psychomotor hyperactivity, convulsions, myasthenia gravis, syncope, lightheadedness, aggression, anxiety, hypoesthesia, hallucinations;
2. Infectious diseases: infrequently - respiratory disease, pharyngitis, rhinitis, candidiasis (including genital and oral mucosa), gastroenteritis, pneumonia; frequency is unknown - pseudomembranous colitis;
3. The digestive system: very often - diarrhea; often - abdominal pain, nausea, vomiting; infrequently - gastritis, constipation, dysphagia, belching, dyspepsia, abdominal bloating, flatulence, dryness of the oral mucosa, increased secretion of the salivary glands, ulcers of the oral mucosa; very rarely - to change the language of color, pancreatitis;
4. Cardiovascular system: rarely - flushing, palpitations; frequency is unknown - ventricular tachycardia, increased QT interval on the ECG, blood pressure, arrhythmia type pirouette;
5. Liver and biliary ways: rarely - hepatitis; rarely - cholestatic jaundice, abnormal liver function; frequency is unknown - hepatic failure (in some cases fatal primarily due to severe liver dysfunction), fulminant hepatitis, liver necrosis;
6. hematopoietic system: eosinophilia, neutropenia, leukopenia; very rarely - hemolytic anemia, thrombocytopenia;
7. Respiratory system: rarely - nosebleeds, shortness of breath;
8. Metabolism: rarely - anorexia;
9. Urinary system: rare - pain in the kidneys, dysuria; frequency is unknown - acute renal failure, interstitial nephritis;
10. Organs of vision and hearing, labyrinth disorders: rarely - blurred vision, vertigo, hearing disorder; frequency is unknown - impaired hearing, including tinnitus and / or hearing loss;
11. Reproductive system: rarely - a violation of testicular function, metrorrhagia;
12. Skin and subcutaneous tissue disorders: uncommon - dermatitis, rash, dry skin, itching, sweating, rash; rarely - photosensitivity; frequency is unknown - erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis;
13. Musculoskeletal System: rare - pain in the back and neck, myalgia, osteoarthritis; frequency is unknown - arthralgia;
14. Local reactions at / in the introduction: often - pain and inflammation at the injection site;
15. Allergic reactions: infrequently - hypersensitivity reaction, angioedema; the frequency is unknown - an anaphylactic reaction;
16. Laboratory data: often - monotsitofiliya, basophils, neutrophils, eosinophils, lymphopenia, increasing the number of platelets, decreased concentration of bicarbonate in the blood plasma, increased sodium content in the blood, increased alanine aminotransferase activity and alkaline asparaginaminotrasferazy phosphatase change of potassium content in the blood plasma, increasing hematocrit, increasing the concentration of bilirubin, urea, creatinine, glucose, chlorine blood plasma.
17. Other: rarely - malaise, asthenia, fatigue, chest pain, facial edema, peripheral edema, fever.

Instructions for use Sumamed

Tablets, film-coated tablets and capsules dispersible. Sumamed taken orally for 1 hour before eating or 2 hours after a meal.

The recommended dose and duration of treatment for children aged 3-12 years old weighing less than 45 kg:

• tonsillitis / pharyngitis caused by Streptococcus pyogenes: 20 mg / kg once per day treatment - 3 days (maximum dose is 500 mg per day);
• infections of upper respiratory tract, respiratory tract, skin and soft tissue: 10 mg / kg body weight once per day treatment - 3 days;
• initial stage borreliosis: the first day - 20 mg / kg once a day on subsequent days - 10 mg / kg once per day treatment - 5 days.

The recommended dose and duration of treatment for adults and children over 12 years weighing 45 kg or more:

• infection of upper respiratory tract, respiratory tract, skin and soft tissues: 500 mg once a day, a course of treatment - 3 days; in acne vulgaris moderate after a standard 3-day course of treatment is continued for 9 weeks (500 mg once a week);
• the initial stage of borreliosis: 1000 mg on the first day, 500 mg on the following days, the course of treatment - 5 days;
• uncomplicated cervicitis / urethritis: 1000 mg dose.

Lyophilizate for preparation of infusion solution

Sumamed administered intravenously over 1 hours (at solution concentration of 2 mg / ml) (at a concentration of 1 mg / ml), or 3 hours. Intramuscular or intravenous bolus prohibited.

A solution for infusion is prepared in two stages:

1. Preparation of the reconstituted solution. Into the vial containing the lyophilisate is necessary to add 4.8 ml of water for injection and mix thoroughly shake to complete dissolution of the powder. In 1 ml of the solution contains 100 mg azithromycin. The reconstituted solution is inspected for the presence of undissolved particles. When found the solution can not be used.
2. Dilution of the reconstituted solution. As the solvent, use Ringer's solution, 0.9% sodium chloride or 5% dextrose solution. The volume of solvent depends on the desired final concentration of azithromycin. For a 1 mg / ml required 500 ml of solvent, 2 mg / ml - 250 ml. The prepared solution was used immediately (assuming no visible undissolved particles, if any are found, it is impossible to apply the solution).

The recommended dose and duration of treatment for adults:

• infectious and inflammatory diseases of the pelvic organs: 500 mg once a day for 2 days (Maximum - up to 5 days) and then once daily 250 mg Sumamed in the dosage form for receiving inside; the overall course of treatment - 7 days.
• community-acquired pneumonia: 500 mg once daily for 2 days (on doctor's decision of course can be extended to 5 days), then the patient is transferred in the form Sumamed oral dose of 500 mg once day; the total course of treatment is 7-10 days;
• Patients with impaired renal function and / or liver mild to moderate severity, as well as the elderly dose adjustment is required.

Oral suspension

Sumamed in the form of suspension for intake prescribe to children aged 6 months to 3 years. The drug is taken once a day for 1 hour before eating or 2 hours after a meal. The suspension should be taken with a little water.

1. To prepare the suspension to the contents of the vial with the powder was added 12 ml of water and thoroughly stirred until homogenous. The resulting volume of around 25 ml, 5 ml of the nominal volume. This discrepancy is provided so as to compensate for inevitable losses suspension Sumamed dosing. The finished slurry may be stored no longer than 5 days at a temperature not higher than 25 ° C.
2. Prepared suspension should be carefully shaken before each dose. Prescribed dose is metered with the enclosed syringe for dispensing or measuring spoon, which should be cleaned and dried after each use.

Dosage slurry similar recommended doses for application of tablets in children 3-12 years of age (in 1 ml of suspension contains 20 mg of azithromycin).

Interaction with Drug

Concomitant use of Sumamed with:

1. Chloramphenicol or tetracyclines: increased efficiency of Sumamed;
2. Dihydroergotamine or ergot alkaloids: strengthening their actions;
3. Ethanol, antacids or food: Sumamed depot;
4. Linkozaminami: reduced efficiency of Sumamed;
5. Carbamazepine, valproate, phenytoin, bromocriptine, xanthine derivatives, Geksobarbitalom, Disopyramide, theophylline or oral hypoglycemic drugs: improving concentration and reducing their time excretion.
6. Indirect anticoagulative agents or cycloserine: slowing their clearance, increase their concentration and toxicity.

Reviews

Some reviews of preparation Sumamed:

1. A child with 3 years suffered from bronchitis every 2-3 months. Plus in the fall of immunity are always joined in the form of herpes stomatitis. The temperature surpasses 40. We started with the weaker antibiotics. Often they were not given effect and had to go to the hospital. With injections and physiotherapy. One lie down in hospital one month. We tried four antibiotic. In four and a half year reached Sumamed. Prescribed by a doctor. Since everything else has been inefficient. Taken from the first day of diagnosis: acute bronchitis. Temperature was 39.3. On the third day the temperature has come to naught. Rattling gone for a week. Exacerbations of herpes infection did not occur. It took only 3 days. By efficiency can deliver the highest score.
2. "Sumamed" undeniably effective in the treatment, but I would recommend it only in extreme cases when there is no response to other, less potent antibiotics, such as penicillin ( "Klamoks", "Amoxiclav", etc.) to take it when I was in school, such as family doctor prescribed. The effect, of course, has come rather quickly, but the recovery period was very long. Plus, in the future, I noticed that the more simple antibiotics are not given such an effect as before. So with this drug need to be careful, because you can make bacteria resistant to antibiotics.
3. I first learned about "Sumamed" a few years ago, very sick, cough does not go nearly 3 weeks. Local doctor wrote me antibiotics which did not help. "Sumamed" advised a friend of mine - a doctor. Very strong antibiotic. I liked that all 3 tablets for 3 days, comfortable, do not forget to drink. On day 3 I felt much better. Even with antibiotics and advised to drink means to restore the stomach and intestinal microflora, but I never saw, because I do not notice any changes. Allergies and rashes on the skin, too, there were not any! Now this is the medicine I have always in the medicine cabinet.
4. I want to tell you about how I helped cure tonsillitis such preparation as Sumamed. Currently, many manufacturers produce antibiotics that do not know how, and to take, but my doctor advised me to use it Sumamed, and I was very pleased with the results. I use the drug 2 times a day, although the manual says 1 time, but the doctor said that it will go faster treatment, and if suddenly there will be side effects from the use, the dose reduced. But nothing I have not appeared, I was 5 days and cutting the drug had completely forgotten that I had a severe tonsillitis.

analogs Sumamed

Traditionally, the most high-quality generic drugs are produced in the European Union. Among them, occupy a worthy place:

• Hemomitsin - drug Serbian company Hemofarm, which has a very affordable price with excellent quality;
• Azitsid production of the Czech company Zentiva.

Indian counterparts Sumamed combines low enough price, but often the quality of some drugs is poor. At our pharmacy you can buy:

• Azitral;
• Azimitsin;
• Zitrotsin;
• Sumamoks;
• azivok;
• Zimaks.

Russian counterparts today compete with European generics:

• Azitroks, the manufacturer - the company Farmastandart;
• Zitrolid production of Valens;
• Z-factor ( "Verofarm");
• Ecomed company Avva Rus;
• AzitRus.

We would like to note the very prominent drug that produces pharmaceutical concern Pfizer - Zetamaks retard. It comes in the form of special microspheres from which azithromycin is released slowly. Distinguishes this generic simply stunning half-life, by which treatment Zetamaksa circuit differs brevity and simplicity. The standard course of drug treatment of single dose in a single day.

prices

The average price of Sumamed in pharmacies depends on the release form:

• Sumamed powder for oral 100mg / 5ml 17g, Pliva Hrvatska doo - 230.00 rubles.
• Sumamed tablets 125 mg, 6 pcs, Pliva Hrvatska doo - 368.00 rubles.
• Sumamed forte powder for oral 200mg / 5ml 20ml - 376.00 rubles.
• Sumamed tablets 500 mg 3pc - 464.00 rubles.
• Sumamed 6piece 250mg capsules, Pliva Hrvatska doo - 465.00 rubles.
• Sumamed tablets 1000 mg dispersible n1 - 517.00 rubles.
• Sumamed Forte powder d / for r. fl suspensions. 200mg / 5ml 30ml - 535.00 rubles.
• Sumamed Forte powder d / for r. fl suspensions. 200mg / 5ml 37,5ml - 565.00 rubles.
• Sumamed tablets 1000 mg dispersible 3 pieces - 1115.00 rubles.

Conditions of supply of pharmacies

Drug prescription.