Miscellaneous

Forsiga 10 mg. Instructions for use, price, reviews, analogues

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Content

  1. Indications for use
  2. Compound
  3. In what form is it produced
  4. Pharmacodynamics
  5. Pharmacokinetics
  6. Application
  7. For children under 18
  8. For adults
  9. For pregnant
  10. For the elderly
  11. Contraindications
  12. Overdose
  13. Side effects
  14. Special recommendations
  15. Drug interactions
  16. Storage conditions and periods
  17. Conditions of dispensing from pharmacies
  18. Analogs
  19. Diaglinide
  20. Glibomet
  21. Invokana
  22. Video about the drug Forsiga

Forsiga is a drug related to pharmaco-therapeutic categories of oral hypoglycemic agents, which are inhibitors of the sodium-dependent transporter of type 2 glucose compounds. According to the instructions for use, this medication is used to treat patients with signs of heart failure and a diagnosis of diabetes mellitus.

Indications for use

The Forsiga drug is prescribed for admission to patients of the adult age group who, due to the presence of diabetes mellitus, are forced to comply with dietary norms, regularly perform a set of physical exercises for the implementation of a more effective glycemic control.

This medication is used for the following purposes:

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  • combined treatment of diabetes mellitus with Metformin, drugs from the thiazolidinediones group, sulfonylurea derivatives;
  • the need for monotherapy of high glucose levels in the blood plasma, when the use of Metformin is contraindicated due to individual intolerance to this drug by the body;
  • concomitant treatment of diabetes with several medications with hypoglycemic properties in the absence of effective glycemic control by the patient.

The Forsiga drug instruction contains comprehensive information on the indications for the use of this hypoglycemic agent. This medication is prescribed for patients with diabetes mellitus who have cardiovascular diseases with the risk of being hospitalized in the hospital of the therapeutic department. The course of taking the drug Forsiga reduces the likelihood of sudden death caused by heart failure.

The Forsiga drug has the following therapeutic properties:

  • reduces the process of glucose reabsorption in the structure of the renal tubules;
  • reduces intraglomerular pressure in the kidneys;
  • helps to lower blood pressure;
  • increases hematocrit;
  • allows you to quickly get rid of excess body fat (this drug is prescribed to patients suffering from obesity and diabetes mellitus);
  • improves metabolic processes in myocardial tissues and kidneys;
  • reduces the level of glucose in the blood plasma on an empty stomach and after a meal.Forsiga 10 mg. Instructions for use, price, reviews

The implementation of the therapeutic properties of the Forsig drug does not cause a disruption in the synthesis of endogenous glucose as a physiological response to an attack of hypoglycemia. The pharmacological action of the active substance of this drug does not depend on the process of insulin secretion, as well as the level of sensitivity of the patient's body to this hormone.

Compound

The table below shows the chemical composition of the drug Forsig.

Components of the drug Dosage
Dapagliflozin propanediol (monohydrate form) The active substance of the drug at a concentration of 12.3 mg, which is equivalent to the content of pure dapagliflozin in an amount of 10 mg
Anhydrous lactose 50 mg
Silica Not more than 3.75 mg
Microcrystalline cellulose Within 171.45 mg
Magnesium stearate 2,5 mg
Crospovidone At a concentration of 10 mg

The chemical composition of the Forsiga preparation contains a synthetic yellow dye Opadray II, talc, as well as a macrogol substance. All components of this product are safe for the human body, do not have toxic and carcinogenic properties.

In what form is it produced

Forsiga (instructions for the use of this medication contain information on the rules for taking it) is hypoglycemic agent, which comes in the form of tablets with a yellow tint, covered with a thin layer protective shell. On one side of the preparation there is a proprietary engraving with the number "10", and on the other - "1428". Forsig tablets are distinguished by a biconvex diamond-shaped shape.Forsiga 10 mg. Instructions for use, price, reviews

Packaging of the medication is carried out in aluminum foil blisters of 10 tablets. in everyone. The main packaging of a hypoglycemic agent is a cardboard box, inside which contains instructions for use. Each pack comes with 3 blisters.

Pharmacodynamics

In clinical testing of the pharmacological properties of Forsiga, healthy people and patients with type 2 diabetes took part. All participants showed increased renal function to remove glucose from the body.Forsiga 10 mg. Instructions for use, price, reviews

Patients suffering from diabetes mellitus took 1 Forsig tablet per day for a therapeutic course of 12 weeks. This dosage led to the elimination of 70 g of glucose from the patient's body within 24 hours. In patients who took a similar amount of medication for 2 years, the rate of effectiveness of therapy remained at the same level.

The drug Forsiga is not addictive even in conditions of long-term treatment. The continuous process of removing glucose from the body with an increase in the functional activity of the kidneys leads to more frequent urination and an increase in the volume of urine. As a result of this process, in most patients, increased sodium excretion by kidney tissues was periodically recorded. After a biochemical study of the patients' blood, it was found that the concentration of this substance in their body remains within the normal range. That is, the Forsiga drug does not cause an electrolyte imbalance.

Pharmacokinetics

Forsiga (the instruction for the drug contains a maximum of useful information) is a medication for oral administration. After the tablet of the hypoglycemic agent has entered the patient's gastrointestinal tract, it rapidly dissolves with further absorption into the intestinal wall. In this case, the order of taking this medication does not matter. Forsig tablets are allowed to be drunk during or after a meal. The maximum concentration of the active substance dapagliflozin in the blood plasma is reached after 60 minutes. after the daily dose of the drug has been taken.

The mass fraction of the main component in the patient's body increases in proportion to the established dosage regimen. The absolute bioavailability of the Forsiga drug in the patient's blood plasma is 78% after taking 1 tablet per day. The distribution of dapagliflozin occurs in such a way that 91% of this substance binds to the proteins of the patient's body. In patients with kidney pathologies and liver tissues, this indicator remained unchanged. The Forsiga drug does not create a critical load on these organs.

According to the results of metabolic decomposition, the active substance dapagliflozin is excreted from the patient's body by the kidneys. Clinical trials have shown that only 2% of this component is utilized unchanged, bypassing the decomposition stage. About 75% of the metabolized dapagliflozin was found in the urine of patients. Another 22% of the decomposition products of this substance were present in the feces. Most of the drug Forsiga, which is excreted through the intestines, remains unchanged.

Application

Forsiga (the medication instruction was compiled according to the results of its clinical studies) is a drug that is taken orally with a small amount of water. The tablets cannot be chewed, but they are taken before, during or after a meal.

For children under 18

This drug is contraindicated in patients under the age of 18.

For adults

Patients of the adult age group who are undergoing monotherapy with Forsig's drug take this drug 1 tablet once a day. In the context of complex treatment with Metformin and other hypoglycemic agents, the optimal therapeutic dosage of dapagliflozin is 10 mg per day. To minimize the risk of a sudden onset of hypoglycemia, it may be necessary to adjust the dosage regimen with drugs that help lower blood sugar levels. For example, medications that stimulate more active secretion of insulin by the tissues of the pancreas.Forsiga 10 mg. Instructions for use, price, reviews

Patients with heart failure are prescribed a standard dosage of Forsig tablets in an amount of 10 mg 1 time per day. The duration of the therapeutic course is set by the attending physician on an individual basis, depending on the general condition of the patient and the clinical manifestations of the disease. Patients with concomitant liver pathologies related to moderate or mild severity do not need to establish a separate dosage regimen. In severe diseases of this organ, the initial dose of the hypoglycemic agent Forsig is reduced to 5 mg.

For pregnant

The drug Forsiga is contraindicated in women who are in a state of pregnancy, as well as breastfeeding a newborn baby. The manufacturer of this medication does not have scientifically proven information on the safety of the active substance of tablets for the fetus and the sensitive body of the baby.

For the elderly

Elderly patients with diabetes mellitus or heart failure are treated with Forsig's medication on a general basis. Correction of the dosage with a hypoglycemic agent is necessary only if a person has severe diseases of the kidneys and liver tissues.

Contraindications

Forsiga (instructions for the use of tablets sets the procedure for taking them) is a safe hypoglycemic agent that is contraindicated in the following cases:

  • individual intolerance to the constituent components of the drug;
  • type I diabetes mellitus;
  • end stage renal failure, as well as other severe kidney diseases that impair their function;
  • ketoacidosis, which developed against the background of diabetes mellitus;
  • congenital lactose intolerance, chronic lactase deficiency, or glucose-galactose malabsorption;
  • the state of pregnancy, regardless of the trimester of intrauterine development of the fetus;
  • lactation of a newborn baby with breast milk;
  • the age of the patient is under 18 years of age (the safety and efficacy of the active substance for patients of this category has not been studied by scientists).Forsiga 10 mg. Instructions for use, price, reviews

The drug Forsiga is prescribed with extreme caution to patients with a history of the following diagnoses:

  • infectious and inflammatory processes in the organs of the urinary system;
  • high hematocrit;
  • severe liver failure.

Monotherapy and combined treatment of diabetes mellitus, heart failure using Forsiga tablets are carried out only for patients who have undergone a comprehensive examination organism.

Overdose

The hypoglycemic agent Forsiga is completely safe and tolerated without the appearance of pathological symptoms, even in cases where a single dose of this drug was 500 mg. This amount of medication was 50 times the recommended therapeutic dosage. Despite an overdose of Forsig tablets, most of the volunteers undergoing examination do not there were signs of arterial hypotension, electrolyte imbalance, dehydration, or hypoglycemia.Forsiga 10 mg. Instructions for use, price, reviews

Patients who have violated the dosage regimen with Forsiga, took too much of this medication, supportive and symptomatic therapy is indicated. Patients of this category should be under constant supervision of medical personnel in the conditions of an inpatient department of a medical institution. There are no clinically confirmed data on the possibility of removing dapagliflozin using a hemodialysis machine.

Side effects

In the process of treating diabetes mellitus and heart failure with the use of Forsiga, the following side effects may occur:

  • decreased immunity;
  • the development of vulvovaginitis in women;
  • the occurrence of balanitis in men;
  • infectious damage to the organs of the urinary system;
  • fasciitis of the perineum with signs of tissue necrotization (in appearance it resembles Fournier's gangrene);
  • an attack of hypoglycemia;
  • feeling of strong thirst, which persists even after drinking a lot of water;
  • ketoacidosis, which occurs against the background of complications of diabetes mellitus;
  • dizziness caused by unstable blood glucose levels;
  • increased dryness of the oral mucosa and the surface of the lips;
  • frequent urination with the excretion of large volumes of urine;
  • pain in the back;
  • violation of the stool with frequent constipation;
  • acute allergic reactions in the form of redness of the skin, itching, the development of angioedema;
  • an increase in the level of urea in the blood.

The most dangerous side effects from taking Forsig are considered to be an attack of hypoglycemia, as well as angioedema. In the latter case, an instantaneous contraction of the larynx lumen with impaired respiratory function is possible. Patients who have encountered adverse reactions of the body in response to the constituent components of Forsig tablets should stop further therapy with this medication. It is recommended that you immediately seek help from your doctor.

Special recommendations

The glycemic activity of the drug Forsiga is reduced in patients with severe functional impairment of the kidneys. In relation to patients with a painful state of these organs of the excretory system, regular monitoring of the biochemical composition of urine for the timely detection of renal symptoms failure. Forsig tablets are prescribed with extreme caution to patients who remain at risk of developing arterial hypotension. Frequent urination with abundant urine flow helps to lower blood pressure.

In patients with diabetes mellitus, cases of ketoacidosis have been observed. With the appearance of nausea, spasmodic pain in the left hypochondrium, vomiting, and shortness of breath, it is necessary to stop further taking the drug Forsiga. Therapy with this medication is completed even if the blood test showed a glucose level within 14 mmol per 1 liter. Patients with similar symptoms are admitted to the hospital of the therapeutic department for a comprehensive examination.

Drug interactions

The Forsiga drug exhibits the following properties of drug interaction with medicines of other pharmacological groups:

  1. Strengthens the diuretic properties of diuretics.
  2. Able to provoke hypoglycemia in the case of simultaneous administration of insulin-based drugs.
  3. Therapy with drugs containing the active substance rifampicin reduces the exposure to dapagliflozin by 22%.
Forsiga 10 mg. Instructions for use, price, reviews
Forsiga 10 mg

The manufacturer of the drug Forsiga does not have clinically confirmed data on the effect of tobacco products, alcoholic beverages and plant extracts on the pharmacological properties of dapagliflozin.

Storage conditions and periods

Forsiga hypoglycemic agent should be stored in a dark and cool place out of the reach of children. The optimum air temperature in the room where this medication is located cannot be higher than +30 degrees Celsius. Otherwise, it is possible to change the biochemical properties of the constituent substances of the drug. The shelf life of Forsig tablets is 3 years, after which the medication must be disposed of.

Conditions of dispensing from pharmacies

The drug Forsiga is dispensed only on the basis of a prescription from the attending physician.

Analogs

On the domestic pharmaceutical market, there are several drugs with hypoglycemic properties, which are analogues of the Forsig drug.

Diaglinide

Diaglinide is a medication for the treatment of type 2 diabetes mellitus, the active ingredient of which is the substance repaglinide. This drug is prescribed for oral administration at a dosage of 0.5-1 mg 3 times a day for 15 minutes. before meals or after 30 minutes. after the meal. The duration of treatment is determined by an endocrinologist. The average cost of the drug Diaglinid is 187 rubles. per pack of 30 tab.

Glibomet

The hypoglycemic agent Glibomet has a combined composition, which includes the substance glibenclamide and metformin. This medication is available in the form of tablets covered with a protective layer. The dosage regimen of Glibomet is selected individually depending on the glucose level in the patient's blood.

In most cases, the starting dose of this hypoglycemic agent is 1-3 tablets per day. The drug Glibomet is taken with meals. The maximum daily dosage with this medication is 5 tablets. The average cost of the hypoglycemic agent Glibomet is 345 rubles.

Invokana

A medicinal product with similar properties Invokana is produced on the basis of the active substance canagliflozin. This medication is available in pill form. The dosage regimen of the hypoglycemic agent Invokana provides for taking 1 tablet 1 time per day on an empty stomach before breakfast. Depending on the concentration of glucose in the patient's blood, the indicated dosage can be adjusted by the attending physician. The average cost of Invokan's medication is 2574 rubles. per pack of 30 tab. with an active substance concentration of 100 mg.

Forsiga is a potent drug with hypoglycemic properties. The active component of this drug is the chemical substance dapagliflozin at a concentration of 10 mg, which is displayed in its instructions for use. The medication is prescribed for patients with type 2 diabetes mellitus and heart failure.

The mechanism of action of the Forsiga drug is to activate the kidney function to remove excess glucose from the blood plasma. Treatment with this drug can be carried out for several years without disrupting the performance of internal organs. The average cost of Forsig's medication in pharmacies ranges from 2070 to 2110 rubles. for 30 tab. The manufacturer of this hypoglycemic agent is the world famous British company AstraZeneca.

Video about the drug Forsiga

Forsiga drug in the treatment of type 2 diabetes:

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