Fluconazole (Fluconazole) suspension for children. Instructions for use, price, reviews

The active substance is fluconazole, which is available in the form of a suspension for children, refers to antifungal agents with specific properties. The action of the drug is based on an increase in the permeability of the cells of the membranes of fungi, in violation of their growth and reproduction. The medicine has a mild effect on the human body.

Where to buy, vacation conditions, drug price

Fluconazole is a well-known artificial antifungal agent that belongs to the group of triazoles used for therapy and prevention infections caused by microscopic yeast-like fungi of the genus Candida, as well as other diseases that develop as a result of the vital activity of parasitic mushrooms. Candida belongs to conditionally pathogenic microorganisms.

You can buy the drug in pharmacies, as well as on specialized online resources. The active substance is mostly available in the form of tablets and capsules. It is difficult to find a powder for preparing a suspension on the market: few pharmaceutical companies are engaged in its manufacture. There is also fluconazole in the form of an intravenous solution based on sodium chloride.

A syrup (suspension) for children's use is produced in vials with dry powder in an amount of 10 or 40 mg per 1 ml of the active ingredient, that is, in a saturation of 1-4%. The drug has a long duration of action and a stage of half excretion, so its use is carried out once a day.

Currently, there is a commercially available dry mixture for the manufacture of a suspension, which can be used internally by children from birth of foreign production. The drug is called Diflucan from the manufacturer Pfizer. It can be purchased at a price of 400 to 600 rubles. (depending on the concentration of the substance). There are 2 types of suspension on sale: 50 ml (10 mg / 1 ml of active ingredient) and 200 ml (40 mg / 1 ml of fluconazole).

The antifungal is available from pharmacies with a prescription.

Composition, release form

Fluconazole (Pediatric Suspension) comes in plastic, screw-capped vials that contain a dry powder. The stopper prevents children from accidentally taking the medicine. It consists of an external and an internal part with a polymeric material gasket. The lid is equipped with a plastic ring that can be removed when first opened.

The carton contains a medicine bottle, a measuring plastic spoon and instructions for use. The bottle is filled according to the dosage of the active substance, in 10 or 40 mg in 1 ml, a homogeneous white powder without visible inclusions.

The composition of the drug in two dosages is summarized in the table:

Substance	1 ml of the finished suspension contains the active ingredient, mg
Fluconazole	10	40
Lemon acid	4,2	4,21
Sucrose	576	546
Sodium hydrogen citrate	3,17	3,17
Sodium salt of benzoic acid	2,37	2,38
Colloidal silicon dioxide	1	0,98
Xanthan	2,03	2,01
Titanium dioxide (dye)	1	0,98
Citrus scent (holds orange ester, water, molasses)	10	10

Operating principle

When ingestion of the drug, the activity of fluconazole is observed in relation to microorganisms of the genus Candida. Some types of fungus are very sensitive to the drug, while others are moderate. Also, activity is observed in relation to cryptococci.

Studies carried out on animals have shown a positive effect of the substance on various types of fungal infections, including mycoses. Well recommended remedy for patients with reduced immunity and meningeal infections.

The main active ingredient has a high selectivity for fungal cells built on large membrane proteins. The mechanism of action is based on the suppression of the biosynthesis of fungal ergosterol, which is produced by the cells of the microflora. In the course of studies with prolonged use of the drug in patients, changes in the amount of male and female hormones in the blood were observed.

Increased resistance to the active substance develops in the following three cases:

• With an increase in the amount of the enzyme, which is affected by fluconazole.
• Upon reaching the goal of the active component.
• With the combination of the above two mechanisms.

Often the drug is prescribed by specialists to prevent fungal infections in patients in the following risk groups:

• in case of oncological diseases, during therapy with antineoplastic agents or during the implementation of radiation treatment;
• after organ transplant;
• when suppressing the body's defenses.

Eating food does not affect the rate of absorption of the drug. The amount of drug that reaches the site of action after 30-40 minutes. after adoption is about 90%. The concentration of the antifungal component in the blood depends on its dosage.

The active substance enters all tissues and body fluids, including breast milk, saliva, sputum, cerebrospinal fluid, sweat. The drug is excreted mainly by the kidneys by 80% in the stored formula and by 11% in the form of metabolic products.

Indications for use

Fluconazole (suspension for children belongs to the group of antimycotics) in the list of indications for use contains the following conditions and pathologies:

• systemic infections caused by fungi;
• candidiasis;
• cryptococcosis;
• meningitis;
• sepsis;
• lung and skin infections.

Often, narrow-profile specialists prescribe a drug to prevent cryptococcal infections. The drug is indicated for admission to patients with a normal immune response and those with depression, including AIDS and organ transplantation.

The list of possible manifestations for which treatment with fluconazole is indicated includes different types of thrush:

• inflammation of internal organs;
• infection of the urinary system;
• infection of the mucous membranes;
• balanitis (inflammation of the foreskin);
• prevention of fungal infections in children suffering from oncological diseases at the stage of radiation and chemotherapy;
• various skin fungal lesions of the limbs, body, groin;
• onychomycosis (nail damage);
• versicolor versicolor;
• endemic mycoses.

Contraindications and side effects

The following conditions serve as restrictions on the prescription of the drug:

• a history of susceptibility to nitrogen antimycotics;
• simultaneous simultaneous intake of erythromycin, amiodarone, terfenadine, astemizole together with fluconazole in dosages over 400 mg per day;
• lack of sucrose;
• maltose deficiency;
• the presence of problems of fructose, glucose-galactose absorption;
• the appearance of rashes;
• if arrhythmic pathologies are observed;
• children who have many risk factors for heart muscle damage;
• disorder of water and electrolyte metabolism;
• deficiency of lactose.

With caution, under the supervision of a physician, the drug is prescribed in case of insufficient renal function.

Fluconazole (suspension for children) as side effects from reception has the following states:

• migraine;
• clouding of consciousness;
• convulsions or loss of coordination of movements;
• insomnia or a feeling of lack of sleep;
• trembling limbs;
• digestive disorders with pain, diarrhea or constipation, bloating, gag reflex;
• diagnosing an increase in the level of bilirubin in plasma;
• deviations from the norm of indicators of liver function;
• cardiac arrhythmia;
• rashes on the skin (Stevens-Johnson syndrome is likely);
• increased sweating;
• a decrease in the amount of hemoglobin in the serum;
• an increase in leukocytes in the blood;
• violation of metabolic processes;
• an increase in cholesterol;
• decreased serum potassium concentration;
• myalgia of the musculoskeletal system;
• anaphylactic reactions;
• increased body temperature;
• rapid fatigue, weakness;
• the appearance of febrile conditions.

In most cases, the suspension is well tolerated, side effects are rare.

Efficiency

The triazole drug fluconazole has proven itself well. The powder for suspension Diflucan is synthesized in the laboratories of the Pfizer company, it is an original product. Numerous scientific studies have shown that with uncomplicated candidiasis infections with the use of the drug in 80-90% of cases, it has a positive effect after one-time admission.

In case of complicated courses of the disease with the manifestation of relapses, experts recommend two-stage therapy tactics, which consist in the following steps:

1. Elimination of exacerbation symptoms. The treatment regimen involves the use of the drug 3 times with an interval of 72 hours, that is, on the first, fourth and seventh days.
2. Continue treatment with the intention of preventing recurrence. Taking medication once a week for six months.

The tool has a wide spectrum of activity, unlike other similar substances. In contrast to ketoconazole, fluconazole acts exclusively against fungal enzymes. However, it does not suppress the synthesis of cortisol, thereby preventing endocrine disorders. With the manifestation of various candidiasis, dermatologists choose a substance as the first choice.

Method of administration and dosage for children

The finished suspension is taken orally. To prepare the substance, it is necessary to add 24 ml of water to the dry contents of the bottle and shake everything thoroughly for 2-3 minutes. Shake the suspension before each next use.

The tool is approved for use pending the receipt of test results. Often, specialists will prescribe treatment before collecting material for bacterial culture or other clinical research. However, according to the results of the analyzes, the doctor adjusts the dosage in accordance with them.

The daily dose of the substance depends on the nature and severity of the fungal infection. The daily amount of the drug intended for a child should not exceed the same dosage for an adult patient. In the presence of different types of candidiasis, doctors prescribe the remedy once every day.

According to the instructions for use, the dosage of the suspension is determined based on the pathology and the intensity of its course as follows:

• Any uncomplicated candidiasis is treated at the rate of a substance of 3 mg per 1 kg of the child's weight per day. At the same time, it is initially possible to double the dosage with the intention of obtaining the required concentration of the substance in the blood already on the first day.
• Experts recommend removing generalized candidiasis and cryptococcal inflammation with a dosage of 6-12 mg per 1 kg of body weight.
• For patients suffering from AIDS, with the purpose of preventing meningitis, a dosage of 6 mg per 1 kg of body weight is recommended.
• To prevent fungal infections in children with suppressed body defenses and the possibility of inflammation, associated with a decrease in the number of neutrophils under the influence of anticancer treatment, the suspension is prescribed at the rate of 3-12 mg per 1 kg weight.
• In the neonatal period up to 4 weeks, the medicine is carefully used, since the antifungal substance is excreted slowly. At the same time, during the first two weeks of life, at a constant dosage, the drug is used with an extended break of 3 days, and at the age of 3-4 weeks the interval between doses is 2 days.

The maximum daily dose for children is 400 mg.

Some analogues, prices

Suspension for children is produced by manufacturers of fluconazole in small quantities. A common medical form for the substance is capsules or tablets.

On sale among the analogues of Diflucan, you can find the following products:

• Mikomax (manufactured by Zentiva, Czech Republic) with the active ingredient fluconazole 5 mg in 1 ml. The bottle is designed for 100 ml of suspension. The cost of the product ranges from 480 to 600 rubles.
• Orungal (manufactured by Johnson and Johnson, Janssen Pharmaceuticals, Belgium) is a syrup for oral use with the active ingredient intraconazole in an amount of 10 mg in 1 ml. A 150 mg bottle can be purchased at a price of 3900 rubles. The syrup has a yellow or light orange color and a cherry smell. It is produced on the basis of an artificial broad-spectrum antimycotic of the triazole series.
• Vfend (manufactured by Pharmacia and Upjohn Company LLS, USA) with the active ingredient voriconazole, included in the triazoline series, with a wide spectrum of action. The product is available in the form of a powder for preparing a suspension in 200 ml vials. The cost of packaging starts at 4900 rubles.

Storage conditions and periods

The medicine must be kept out of the reach of children. The storage temperature should not rise above 30 ° C. Suspension Diflucan is produced for a shelf life of 36 months. After the expiry of the end date of use, the product is prohibited from admission. If a suspension is prepared, it should be kept in a dark place at an ambient temperature of no more than 30 ° C. It cannot be frozen. The finished suspension can be used for 14 days.

During the treatment of fungal infections with a suspension for children based on fluconazole, it is necessary to monitor blood counts and kidney function. If symptoms of organ dysfunction appear, you should stop taking the drug. In this case, the toxic activity of the active substance quickly ceases and the symptoms disappear.

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