Curantil and analogues during pregnancy. List of Russian production, price, reviews

Curantil is often the drug of choice for treatment placental insufficiency during pregnancy. The tool normalizes blood supply to the placenta, ensuring an adequate supply of nutrients and oxygen to the fetus. There are also several analogues on the pharmacy shelves. Each of them has its own distinctive features.

Characteristics of the drug

The active ingredient in Curantila is dipyridamole.

Dipyridamole has several therapeutic properties:

• Antiplatelet action. It prevents platelets and erythrocytes from sticking together, thereby reducing blood viscosity. Thanks to this, the blood thinns and flows faster through the bloodstream to the fetus.
• Vasodilating action. Dipyridamole expands and relaxes the walls of blood vessels, and also improves blood circulation not only in the placenta, but also in the structures of the brain and heart muscle.
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• Immunomodulatory action. Curantil is an inducer of interferon, increasing its synthesis in leukocytes. Thus, the drug increases the body's defenses and resistance to viral diseases.

The medicine has 2 forms of release:

• film-coated tablets, 25 mg of dipyridamole;
• film-coated tablets, 75 mg of dipyridamole.

In obstetrics and gynecology, the smallest of them is most often used. It has been proven that the drug in a dosage of 25 mg improves blood circulation, the supply of the fetus with substances and oxygen necessary for development.

In addition to this area of ​​application, Curantil is used:

• In cardiology, for the prevention of coronary heart disease, arterial and venous thrombosis, as well as a means to prevent thromboembolism. This is especially true after heart surgery when installing artificial valves.
• In neurology. For the treatment and prevention of cerebral blood supply disorders of the ischemic type. This occurs due to partial or complete blockage of the lumen in the vessel, which leads to damage to tissue or an entire organ.
• In immunology. It is known that dipyridamole in a dosage of 25 mg belongs to an interferon inducer, therefore it can be used for the prevention and treatment of acute respiratory infections and other viral diseases.

There can be several effects from the use of Curantil for the expectant mother.

Namely:

• headache passes, dizziness stops;
• excess fluid is removed, edema subsides, the load on the kidneys decreases;
• blood pressure drops to normal values;
• the cramps of the calf muscles, which so often torment pregnant women at night, pass.
• Thanks to the immunomodulatory effect of the drug, when taken, the body of the expectant mother receives a strengthening of immunity and additional protection against viral infections. This is a significant bonus, because during the period of bearing a child, a woman is especially susceptible to various diseases, which can affect the development of the child.

Basic instructions

Curantil has a whole list of indications for use.

Among them:

• discirculatory encephalopathy (violation of the blood supply to the brain, is a consequence of arterial hypertension);
• prevention of ischemic heart disorders, especially important when it is impossible to use aspirin as an antiplatelet agent and looking for an alternative;
• prevention of thrombosis,
• treatment of complications of thrombosis,
• prevention of postoperative complications such as thromboembolism;
• in a dosage of 25 mg, the agent can be used to prevent or treat ARVI, flu and colds.
• Curantil and analogues during pregnancy can be used as a prophylaxis and treatment of disorders of blood circulation in the placenta, as well as to reduce blood clotting or eliminate edema.

Kurantil's analogs during pregnancy of Russian production

The manufacturer of Curantil is the German pharmaceutical company Berlin-Chemie / Menarini Pharma GmbH. However, this is far from the only dipyridamole drug on the modern drug market. There are several analogues of Russian production.

Among them:

• Dipyridamole 25 mg and 75 mg, manufacturer "Ozone";
• Dipyridamole 25 mg and 75 mg, manufactured by Vertex;
• Dipyridamole-FPO 50 mg and 75 mg, manufacturer "Obolenskoe".

As you can already understand by similar names, all of the listed drugs are complete analogues of Curantil. This means that they have an identical composition and similar release forms. Also, drugs, as a rule, have the same dosage regimen, list of indications, contraindications and side effects.

Any of the compared products is dispensed from the pharmacy organization only by prescription and can be used after consulting a doctor. Self-medication with this category of drugs is strictly prohibited and can lead to dangerous consequences, up to extensive bleeding and hypotension.

Dipyridamole produced by "OZONE"

Curantil and analogues during pregnancy, as a rule, have the same dosage. For this reason, the company "Ozon", which is located in the Samara region, g. Zhigulevsk also produces its Dipyridamole at 25mg and 75mg.

This tool is also approved for use during pregnancy. It has been proven that it improves blood circulation in the placenta, preventing fetal hypoxia.

Despite the fact that the drug is identical in composition to Curantil, their pharmacokinetics are somewhat different. So, the active substance Curantila reaches its maximum concentration in the blood plasma after 60 minutes. after taking, while dipyridamole from "Ozone" this figure is 75 minutes.

In simple terms, the therapeutic effect of a domestic drug occurs somewhat later. In some cases, this can be a decisive factor for the well-being of a woman and an unborn child.

Speaking about the dosage regimen, it should be noted that for the prevention of placental insufficiency, Curantil should be taken three times a day, 1 tablet (25 mg), unless the doctor has prescribed otherwise. However, it is important to remember that the maximum daily dosage for a pregnant woman should not exceed 225 mg.

The duration of the course is determined by the gynecologist individually for each patient. The drug is recommended to be taken on an empty stomach, without chewing, washed down with a sufficient amount of drinking water. Other drinks (tea, coffee, juice) are not suitable for this purpose, as they can disrupt the absorption of the drug.

In the instructions of the drug from "Ozone" there is no clearly prescribed scheme for pregnant women. However, gynecologists, as a rule, prescribe the drug in the same way as the Curantil dosage regimen.

Dipyridamole by Vertex

An analogue of Kurantila is produced at the plant in g. Moscow in a dosage of 25 mg and 75 mg. During pregnancy, doctors prescribe 25 mg 3 times a day.

After a detailed study of the drug and its comparison with the previous one from "Ozone", you come to the conclusion that they are no different. However, they have at least one difference. This is the manufacturer.

The maximum plasma concentration is achieved similarly to its domestic counterpart after 75 minutes, side effects occur more often than with the original drug.

The instructions for use of this drug indicate that women who are expecting a child can use the drug only if the expected benefit to the mother is higher than the possible risk to the fetus. Kurantil also says that use during pregnancy is possible according to indications.

Why are the drugs similar, but their instructions are still different? The fact is that the manufacturers of domestic dipyridamole did not conduct independent clinical studies that would prove the safety of taking their drug in pregnant women. Therefore, disclaiming responsibility in this matter, they shift it to the doctor and the patient and leave the decision to them.

While releasing the original drug, the German pharmaceutical company conducted a series of long-term trials, so in their instructions they officially authorize the drug during pregnancy.

Dipyridamole-FPO produced by "Obolenskoe"

The product is produced in the Moscow region. Unlike its competitors, the drug does not have a 25 mg release form, and is available in the form of 50 mg and 75 mg tablets.

In this regard, the drug should be prescribed only by prescription when the gynecologist believes that a dosage of 25 mg will not be enough to provide a therapeutic effect in a particular pregnant patient. Independent use of dipyridamole in any dosage is strictly prohibited.

Like their domestic counterparts, the instructions for this drug indicate 75 minutes. as the period of reaching the maximum concentration of the drug in the blood.

Curantil and analogues during pregnancy have similar information in the instructions for use, including the same list of unwanted side effects:

• increased heart rate, rush of blood to the face and neck, lowering blood pressure below normal;
• nausea, vomiting, diarrhea, abdominal pain;
• a decrease in the number of platelets in the blood, increased bleeding;
• headache, tinnitus, dizziness;
• skin rash, itching, swelling of the oral mucosa and esophagus.

Despite this, in the case of taking Curantil, the frequency and severity of adverse reactions is lower compared to Russian counterparts. Clinical trials have shown that the use of a German drug in an adequate dosage rarely causes side effects.

If they appear, they are of minor severity and, as a rule, go away on their own without requiring medical intervention. An exception is an allergic reaction to the drug, when relief of symptoms with an antihistamine is required and a doctor's consultation is required.

The frequency and severity of side effects is an important point in the choice of drugs for pregnant women. After all, many drugs designed to relieve side effects are simply prohibited for pregnant women.

For example, if allergies develop, you will have to take an antihistamine, putting yourself and your child at risk. In addition, you will also need to purchase an allergy medication. Therefore, if the patient wants to find an analogue cheaper than the original, then the savings here is a dubious plus.

Price of funds

Name	Price
Curantil N 25 No. 120	RUB 680-730
Dipyridamole from Ozone 25 mg No. 100	390-440 rub.
Dipyridamole from Vertex 25 mg No. 120	420-470 rub.
Dipyridamole-FPO 50 mg No. 120	RUB 500-550

The cost of drugs may differ, as it depends on many factors (region, city and the selected pharmacy chain).

It is worth noting that Vertex Dipyridamole is available in packs of 100 tablets, while the rest contain 120 tablets in a pack. Wanting to save money, people often do not pay attention to this fact. But 20 tablets provide almost a week course of treatment of placental insufficiency in pregnant women (3 times a day, 1 tablet).

Therefore, wishing to purchase the drug profitably, you need to recalculate the cost of 1 tablet or day of treatment.

• Curantil: 705 (average cost of a package) / 120 (number of tablets in 1 package) = 5.88 rubles. - so much will cost the buyer 1 tablet of Curantil. It turns out that the daily cost of treatment (three times a day, if the doctor has not prescribed otherwise) = 17.63 rubles.
• Dipyridamole from Ozone: 315/100 = 3.15 rubles. (for one tablet) or 9.45 rubles. per day of treatment.
• Dipyridamole from Vertex: 445/120 = 3.71 rubles. or 11.13 rubles.
• Dipyridamole-FPO from Obolenskoye is available in two dosages, but the smallest of them is 50 mg, which is not always suitable for pregnant women. The cost of one 50 mg tablet will cost the customer 4.4 rubles. (525/120).

If we talk about the last of the presented funds, some experts suggest taking a dosage of 50 mg and dividing it in half, and the patients agree, because they are sure of the benefits of such a purchase.

But, if you carefully look at the instructions for use, you can find that each of the manufacturers prohibits crumbling or chewing the pill, recommending drinking them whole. Therefore, if the gynecologist prescribed a dosage of 25 mg, then this is the dosage that should be taken from the pharmacy.

Curantil has several Russian analogues that have a lower cost. However, do not forget that analogues have a higher risk of developing adverse reactions, which is completely undesirable during pregnancy. Therefore, whenever possible, priority should be given to the original drug, and not to its analogues.

Video about the drug

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