Reslip. Indications for use, instructions, price, reviews

To medicines helping to get rid of sleep problems, refers to Reslip. This drug has one single indication for use: it is used to restore the sleep-wake cycle. The drug, according to reviews, is easily tolerated by the body and quickly eliminates insomnia.

Release form and composition of the drug Reslip

Reslip is produced in the form of white oblong tablets with a film coating that protects the mucous membrane of the esophagus and stomach from the harmful effects of the active substance. Manufacturers pack tablets in packages of different sizes according to cell contour blisters. One cardboard box can contain from 1 to 4 blisters of 5, 7 or 10 tablets each.

Reslip, a preparation for sound sleep, is based on doxylamine succinate. In each tablet, it is present in the amount of 15 mg.

Additional components are:

• lactose monohydrate;
• aerosil;
• povidol;
• cellulose;
• magnesium stearate;
• macrogol 6000;
• titanium dioxide.

Thus, there is only one active ingredient in the composition of Reslip - doxylamine succinate. The rest of the compounds are used to give the medication a convenient tablet form.

Pharmacological properties

To understand how Reslip works with sleep problems, it is necessary to dwell on the features of the effect of doxylamine succinate on the human body. This substance is a blocker of histamine receptors included in the ethanolamine group. In addition to sleeping pills, the drug produces antiallergic and sedative effect.

As a result of using these tablets in a patient:

• falling asleep time is significantly reduced;
• the duration and quality of sleep increases;
• the cyclicity of sleep phases remains.

Taking pills provides at least 6-8 hours of good rest for the body, followed by a light comfortable awakening.

Pharmacodynamics and pharmacokinetics

The active substance, entering the bloodstream through the walls of the small intestine, acts on the same principle as any other blocker of histamine H1 receptors. Since histamine is one of the key neurotransmitters of wakefulness, retaining it allows sedation. This is why most of the antihistamines used to treat allergic reactions cause drowsiness as an adverse reaction.

Reslip, whose indications are usually associated with insomnia, has M-anticholinergic properties, due to which a long-term hypnotic effect is produced. At the same time, the drug improves the quality of sleep: the patient sleeps soundly for at least 6-8 hours in a row, which after waking up allows him to feel a surge of energy and strength.

Once in the gastrointestinal tract, doxylamine succinate is absorbed into the bloodstream without residue. The maximum concentration of the absorbed substance in the blood plasma becomes approximately 2-2.5 hours after taking the tablet. Doxylamine succinate has penetrating properties, overcoming the membranes of the cerebral cortex, the lungs.

The drug goes through all stages of metabolism in the liver, leaving the body unchanged with urine, and also partially with sweat and excrement. In healthy patients, it takes about 10-12 hours from the moment the tablet enters the esophagus until it is completely eliminated, but in people with kidney or liver dysfunction, the period may last longer.

Indications for use

The reason for the appointment of the Reslip tablets speaks for themselves by their name. This drug is recommended for use in order to eliminate sleep disorders that have arisen against the background of various diseases or pathological conditions, the treatment of which involves, among other things, eliminating the cause insomnia.

You can take Reslip if you have problems such as:

• prolonged stress;
• neurotic condition;
• exacerbation of chronic mental disorders;
• pathology of the central nervous system;
• taking psychotropic drugs;
• hormonal disruption during pregnancy, menopause;
• severe pain syndrome;
• unfavorable conditions for quality sleep;
• work at night;
• shift work;
• frequent change of time zones.

A healthy person falls asleep quickly (in 5-10 minutes), and in patients with sleep disorders, this action can take up to 2 hours or more, even in the presence of the most favorable conditions for quality sleep.

Also insomnia is frequent awakening in the middle of the night, a feeling of the so-called "shallow" sleep. Moreover, awakening can be caused by both endogenous and exogenous factors. Sleep disorders lead to problems of untimely, often too early awakening, which in in turn leads to a decrease in performance, concentration and mental activity throughout day.

Contraindications

Reslip (indications for use are reduced to numerous causes of insomnia) has many limitations for patients.

Among them, it is worth noting absolute and relative contraindications:

Type of restrictions	Diseases	Consequences of taking in the presence of contraindications
Absolute	Closed-angle glaucoma	Doxylamine succinate is able to block the outflow of fluid and provoke an increase in intraocular pressure.
Diseases of the urinary tract, accompanied by stagnation of urine	Intoxication with an active substance accumulated in the body
Relative	Partial liver or kidney dysfunction	Intoxication with an active substance accumulated in the body
Apnea	Increased episodes of respiratory arrest during sleep, the development of brain cell hypoxia.
Elderly age	Movement coordination disorder, dizziness, psychophysical lethargy.
Lactase deficiency	Ineffectiveness of the drug, ineffective use

Laboratory studies have confirmed the possibility of using Reslip tablets in women during pregnancy. Doxylamine succinate is unable to penetrate the placenta and have a negative impact on the formation, development and growth of the fetus.

At the same time, Reslip is not suitable for use by lactating women. If it is not possible to replace this drug with a safer one, it is better to suspend breastfeeding. If doxylamine is unable to overcome the placental barrier, then it penetrates into breast milk quickly.

At what age can the drug be used?

Reslip should not be given to children under 15 years of age.

Sleeping pills are contraindicated at this age for the following reasons:

• such medications disrupt the learning and maturation of the brain;
• children easily develop drug dependence on potent drugs;
• there is a risk of damage to internal organs due to age-related immaturity of the liver and kidneys.

Instructions for use, dosage

Reslip tablets for sound sleep should be taken with 30-50 ml of water. In order for the drug to take effect, you need to drink it no later than half an hour before going to bed.

The optimal dose recommended by most experts is 1 tablet a day in the evening before bedtime. It is recommended to start treatment with taking half of the indicated dose. In the absence of positive dynamics for 2-3 days, you should consult your doctor. The specialist will select an analogue or suggest doubling the dosage.

It is undesirable to take pills for insomnia for more than 10 days in a row. If the symptoms of sleep disturbance persist after the course of therapy, the patient may be assigned a more detailed examination to determine the true cause of the sleep problems.

Due to the fact that doxylamine is excreted from the body for a longer time with incomplete functionality of the liver and kidneys, patients suffering from diseases of the hepatobiliary or urinary system, the drug is allowed only in reduced dosage. The same applies to patients over 65 years of age.

Side effects

Reslip, which has a single indication for use, is not a completely safe drug. It must be used with extreme caution in order to avoid the development of side effects from various systems and organs.

The most common adverse reaction is digestive upset. Reslip often causes constipation, nausea, dry mouth, and may cause temporary loss of appetite. The second most common negative effect is observed on the part of the heart and blood vessels. According to reviews, patients feel palpitations, arrhythmias, and a decrease in blood pressure. For the period of treatment with Reslip, a short-term decrease in visual acuity is also possible.

Among the side effects of taking a sleeping pill, it is worth noting daytime sleepiness, which often indicates an excess of the required dosage.

As a rule, adverse reactions to the drug are intermittent and disappear immediately after the cancellation of Reslip without the use of any additional medications. If the side effects become more pronounced or other symptoms not described above join them, it is imperative to inform the attending physician about this.

Overdose

With a moderate overdose with Reslip, the same symptoms are observed as with an adverse reaction to this drug. An excess of doxylamine succinate in the blood leads to constant drowsiness, periodically alternating with hyperactivity, mydriasis and other accommodation disorders.

With a single dose of the drug that is significantly higher than the recommended dose, more severe disruption of life, up to a disorder of consciousness, the development of epileptic syndrome and coma.

Their harbingers can be:

• dry mouth;
• redness of the skin of the face and neck;
• increased body temperature;
• hallucinations;
• tachycardia;
• sense of anxiety;
• tremor of the limbs;
• lack of coordination of movements.

An excess amount of doxylamine succinate in the body is fraught with the development of such a destructive process as rhabdomyolysis - a condition in which skeletal muscle tissue rapidly dies, releasing creatine kinase into the blood and myoglobin. These substances are metabolic waste products and cause acute renal dysfunction. Involuntary body movements, convulsions can indicate the beginning of the radomyolysis process.

In case of an overdose with Reslip, symptomatic therapy is prescribed, which is based on the intake of m-cholinomimetics, glucose and sorbents.

special instructions

Reslip, the indications for the use of which are prescribed in the manufacturer's instructions, should not be taken without a confirmed problem. Insomnia can be the result of a number of internal and external factors, but not all cases require the use of a potent sleeping pill. In this regard, a patient suffering from insomnia and other sleep disorders should consult a doctor and make sure that it is advisable to use Reslip tablets.

During the period of treatment with this drug, it is important to consider that it has a strong sedative effect, suppressing cognitive functions. This property of sleeping pills is of particular importance for persons whose professional activities are directly related to the management of transport and complex mechanisms.

A similar recommendation applies to ordinary motorists taking Reslip tablets - due to the high the likelihood of daytime sleepiness from driving a car is better to completely abandon for the period of the course treatment.

Medications from the groups of hypnotics and sedatives can aggravate sleep apnea syndrome. If respiratory arrests occur more often against the background of the use of Reslip, become more prolonged, the use of the drug should be suspended until consulting a doctor.

Apnea as well as glucose-galactose malabsorption are not grounds for a categorical ban on taking doxylamine succinate, however, with such concomitant problems, the use of tablets must be treated with special caution.

Drug interactions

Reslip is a medication that is not forbidden to be combined with other drugs, however, when used simultaneously with a whole a number of pharmaceutical agents increase the inhibitory effect on the central nervous system, the risk of poisoning and the development of severe reactions increases organism.

Such drugs that do not interact with Reslip include:

• antidepressants based on trimipramine, doxepin, mianserin, amitriptyline, mirtazapine;
• barbiturates;
• benzodiazepines;
• morphine derivatives (analgesic and antitussive compounds);
• antipsychotics;
• antihypertensive drugs;
• muscle relaxants.

When Reslip is combined with drugs based on atropine, imipramine antidepressants, drugs for the treatment of Parkinson's syndrome, the risk of urinary retention, constipation, and dry mouth increases. Also, do not drink sleeping pills with ethanol-containing medicines and alcoholic beverages.

Analogs

At the moment, in the assortment of pharmaceutical products in Russia, there are many analogues of Reslip with an identical composition. If this drug for any reason cannot be used by the patient, he is prescribed drugs, included in the same group of medicines and having the same mechanism of action, but containing a different active component.

The decision to replace the drug must be made by the attending physician - otherwise, self-medication can lead to acute adverse reactions.

• The complete analogue of the Reslip tablets can be called Donormil. It belongs to the group of prescription hypnotic antagonists of H1-histamine receptors. Since the composition of Reslip and Donormil contains the same active ingredient, it is difficult to find the difference between them. And yet it is: Reslip is a Russian generic of Donormil, produced in France. Also, the difference can be found in the number of tablets per package: there are always 30 of them in Donormil.
• Second common substitute Reslipa - a product of Irish origin Zolpidem. This drug is a hypnotic from the group of imidazopyridines. This medication acts on a different principle, inhibiting omega-1-benzodiazepine receptors. Zolpidem allows you to achieve the same treatment result, reducing the time it takes for the patient to fall asleep and the number of nighttime awakenings. Unlike Reslip, Zolpidem does not cause drowsiness during the day.
• Imovan - another representative from the group of sleeping pills, which is produced in France by Sanofi Winthrop Industry. Unlike Reslip, Imovan belongs to cyclopyrrolones. The advantage of this analogue is that it is not drug-dependent even with prolonged multi-week use.
• Among the inexpensive Russian counterparts, it is worth noting Nitrazepam It is a hypnotic from the benzodiazepine group. The effect of the drug occurs 25-40 minutes after taking the pill due to the inhibition of the "REM sleep" phase. Unlike Reslip, Nitrazepam can be prescribed to children from 4 months. The indications for this should be not only insomnia, but also more serious disorders (epileptic seizures, infantile spasms, nodding convulsions). The drug is not used during pregnancy.

Terms, conditions of sale and storage

Reslip (indications for the use of this drug do not require medical confirmation, therefore it is dispensed without a prescription) can be bought only if there is an official recommendation from the attending specialist. Sleep pills should be stored in a place protected from light, to which children do not have access. The optimum temperature for storing tablets is 25 ° C. After 2 years from the date of manufacture, the drug is considered unusable and subject to disposal.

Price

The cost of packaging a medicine with 10 tablets is on average 130-150 rubles. For 30 tablets, you will have to pay about 300 rubles. In comparison with analogs prescribed for the same indications for use, Reslip is one of the most inexpensive and effective sleeping pills.

Video about the drug Reslip

Instructions for sleeping pills Reslip: