Phosphogliv is a new generation hepatoprotector. It has already earned fame and respect in medical circles, but now it is gaining popularity as a drug that users recommend to each other without a doctor's recommendation. In order for the impression of the use of Phosphogliv to be correct, you need to figure out when the drug is used independently, when in complex therapy, what to look for when taking it. Below is information about everything that Phosphogliv is - the use and reviews of doctors and patients, contraindications and prices.
Compound
The active ingredients are Sodium glycyrrhizinate (trisodium salt of glycyrrhizic acid) and phospholipids (Phosphatidylcholine).
pharmachologic effect
The first and main component of Phosphogliv, the glycyrrhizic acid salt, has an anti-inflammatory effect. and is a natural antioxidant, and also prevents the growth of scar tissue at the site of the dead hepatocytes.
The second component, phosphatidylcholine, is a mixture of natural or essential phospholipids. These organic compounds are part of cell membranes, incl. membranes of liver cells - hepatocytes. Phosphatidylcholine in Phosphogliv strengthens the membrane of hepatocytes and protects them from damage, improves the delivery of glycyrrhizic acid to hepatocytes. Along the way, it normalizes protein and fat metabolism, which is also important for the liver.
These two components of Phosphogliv mutually reinforce and complement each other, prevent the development of sclerotic, dystrophic and tumor processes in the liver.
Indications for use
As a separate drug, Phosphogliv is used for various forms of liver dysfunction:
- fatty hepatosis (steatosis, steatohepatitis) and other degenerative liver damage (liver fibrosis in the early reversible stages);
- medicinal, toxic and alcoholic liver damage.
As part of the complex therapy (together with the main therapy of these diseases):
- viral hepatitis (acute and chronic),
- cirrhosis of the liver;
- psoriasis (addition to external therapy, ultraviolet radiation).
Thus, from the use of Phosphogliv, one can expect a positive effect in any reversible stages of liver disease. (from hepatosis to fibrosis of 2-3 degrees), but in chronic diseases, its use is justified in combination with the main treatment. Thus, cirrhosis of the liver is an irreversible change, when the liver by itself can no longer recover, it needs a transplant. Phosphogliv, along with the main therapy, will be able to support it, but restore it completely - no.
Fortunately, the development of medicine has made a giant leap forward in the treatment of hepatitis, and if earlier hepatitis C was cured only in 40-60% of cases, now the cure rate is almost 100%. Accordingly, the role of Phosphogliv is complex here.
In addition to the liver, the body also gets rid of toxins with the help of the skin. That is why skin diseases can lead to functional disorders of the liver. And vice versa - liver disease can contribute to the appearance or exacerbation of skin diseases. One of the most common is psoriasis, a chronic non-infectious skin lesion.
In this case, the action of Phosphogliv is of a double nature - removal of skin inflammation, as well as stopping the inflammatory process in the liver. But taking specific drugs, ointments and UFO therapy is mandatory. Phosphogliv will improve treatment results and prolong remission.
Application
Few people know that liver diseases in 80% are imperceptible and asymptomatic. Often, patients learn about fatty hepatosis or even onset fibrosis by accident during examination, when the doctor finds an increase and hardening of the liver or an increase in the activity of the liver enzymes AST and ALT in the biochemical blood test.
We often do not notice fatigue, and under tan or makeup we do not see yellowed skin. Thus, the "silent" liver presents a surprise even in advanced stages, when urgent help is required. Therefore, in order to quickly relieve inflammation and start the liver recovery process, treatment begins with a course of injections (Phosphogliv: powder for injection), which are prescribed by the doctor in the treatment room or day hospital.
Mode of application:
Sterile powder Phosphogliv lyophilisate is diluted with sterile water for injection in a volume of 10 ml. Introduce 10 ml intravenously slowly 2 times a day, morning and evening, or the entire daily dose once. Injections are made within 10 days: every other day (day - injections, day - capsules), or 5/2 (5 days in a row - injections, 2 - capsules, 5 - injections).
After the course of injections, they must switch to taking capsules. They are taken in 2 pieces. 3 times a day during meals with a little water.
If taking Phosphogliv has a prophylactic purpose - after taking medication or errors in food and alcohol, then the capsules can be used without a preliminary course of injections.
Contraindications
- Individual intolerance to phosphatidylcholine and glycyrrhizic acid
- APS (antiphospholipid syndrome)
- Age up to 12 years
- Caution for portal hypertension
- With caution in high blood pressure
Like any tested and studied drug, Phosphogliv has contraindications and side effects. The latter are not always associated with the drug itself (for example, indigestion or so-called dyspepsia), part of the side effects associated with the fact of experiencing the instructions read, the very fact of the need to be treated, but the manufacturer is obliged to inform about them in instructions.
Side effects
- allergic reactions such as skin rash, rhinitis, conjunctivitis
- increased blood pressure
- peripheral edema
- stomach ache
- nausea with belching and flatulence
To clarify safety aspects, there is not only the opportunity to complain to a doctor and clarify whether there is a connection with taking the drug or not. In clinical studies in which the action and side effects of Phosphogliv were compared with those who, instead of Phosphogliv took placebo, it turned out that Phosphogliv was superior to placebo in effectiveness, and safety comparable. Those. side effects when taking Phosphogliv are noted no more often than when taking a placebo pacifier.
Nevertheless, a slight increase in blood pressure was recorded only in 1.7% of cases, it was temporary and easily amenable to correction.
During pregnancy
Contraindicated during pregnancy and breastfeeding.
Overdose
No cases of overdose have been identified
Interaction with other medicinal products.
Not described.
Influence on the ability to drive vehicles and work with mechanisms. The drug does not adversely affect the ability to drive vehicles and perform other work that requires increased concentration of attention and speed of psychomotor reactions.
This means that taking Phosphogliv, you can safely work and drive a car or motorcycle. Why is it important? Because there are hepatoprotectors (ademetionine Heptral) that have a negative effect on the reaction, which can lead to injuries at work or accidents.
Combination with alcohol
Alcohol is not an antagonist of Phosphogliv, but it has a negative effect on the liver. Therefore, you should refuse to take alcoholic beverages while taking Phosphogliv. In extreme cases, it is allowed to take a small amount of alcohol during treatment with Phosphogliv or in between courses.
Storage
Shelf life is 3 years. Store at a temperature not exceeding 25 ° C in a dark place.
Reviews
About the properties of Phosphogliv and its use - reviews are mostly only positive. As we already wrote above - Phosphogliv has long earned the respect of doctors, coming to the fore in the recommendations, standards and prescriptions for liver diseases.
However, you can also find negative ones. So, patients who took Phosphogliv 1 capsule 2-3 times a day, with a course of 1-1.5 months, complain of insufficient effectiveness, i.e. violating the scheme of admission the drug, as well as those who started taking capsules without a preliminary course of injections in severe advanced cases or with indications where Phosphogliv was in combination with the main therapy.
In some cases, the use of Phosphogliv was not accompanied by changes in lifestyle, i.e. alcohol was taken and no one thought about a little bit of a diet and restrictions in sweet and fatty foods. It turns out that in such people the drug was ineffective not because of the drug, but because the basic recommendations were not followed.
Fortunately, there are not many of them, since doctors clearly explain how to take the drug correctly, and the scheme in the instructions is very simple - 2 capsules 3 times a day, 3 months. Further on the normalization of blood tests and ultrasound examinations.
To summarize, the reception according to the scheme and in accordance with the severity of the inflammatory process of the liver is the key to successful treatment and positive feedback about Phosphogliv. In general, reviews of the drug boil down to the normalization of AST and ALT in the blood, improving vital activity, well-being, normalizing digestion and the appearance of the skin.
Patient Testimonials
After taking the drugs, many patients with hepatic diseases have an increase in appetite and digestive disorders disappear. Often, prolonged use of capsules leads to an improvement in appearance. In addition, after a course of Phosphogliv, with regular use, reviews indicate an improvement in well-being after plentiful holiday feasts.
Reviews of doctors
Experts note the effectiveness of taking Phosphogliv in chronic liver diseases. The effectiveness is especially noticeable if liver diseases are associated with diabetes mellitus, obesity and other metabolic disorders. At the same time, Phosphogliv, made from natural raw materials, is well tolerated, and side effects are extremely rare.
Phosphogliv's analogs
There are no analogues of Phosphogliv - this is an original remedy. The composition is patented. There are no similar drugs with glycyrrhizic acid in Russia.
But there are a number of drugs that also contain the same phospholipids as active ingredients:
- Essentiale forte N
- Essliver forte
- Rezalut Pro
- Eslial forte
As we already understood, phospholipids themselves are of little use if the inflammation that destroys the liver is not eliminated by lifestyle changes and Phosphogliv intake. Of course, there are other drugs for the treatment of liver diseases (the group of hepatoprotectors is old, quite extensive).
For example, most may be familiar with such names as Carsil, Heptral, Ovesol, Liv 52, Hepatrin, etc. But you need to know that some of them these are just dietary supplements without a proven therapeutic effect of treatment or at least some significant prevention, some of them are already morally obsolete drugs, while others are generally indirectly related to hepatoprotectors, tk. are amino acids, and liver protection is not the main thing for them destination.
Of course, these funds can also be effective in some stages of liver diseases, but they only remove the manifestations. At the same time, Phosphogliv not only eliminates symptoms, but also affects the key links in the mechanism of development or pathogenesis of these diseases.
In addition, Phosphogliv does not differ much from many other hepatoprotectors in terms of price. And, of course, it is more profitable to purchase a more reliable, effective and safe product at the same cost.
