Miscellaneous

Angiotensin 2 (II) receptor antagonists. List of drugs, mechanism of action, classification, indications, contraindications

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Content

  1. Classification
  2. Rating of drugs from the pharmacy
  3. Angiakand
  4. Irsar
  5. Lozap
  6. Mikardis
  7. Valsacor
  8. Vasotenz
  9. Diovan
  10. Lorista
  11. Candesartan
  12. Telmisartan
  13. Angiotensin Receptor Antagonist Videos

To the category of antihypertensive drugs include antagonists (blockers) of angiotensin 2 receptors, which help to significantly reduce the activity of the renin-angiotensin-aldosterone system. With the correct use of a medication prescribed by a doctor, it is possible to reduce the tone of the blood vessels. vessels, improve the diastolic function of the myocardium, as well as minimize the likelihood of cardiac hypertrophy muscles.

Angiotensin 2 receptor inhibitors (sartans) can provoke adverse reactions from the respiratory system and the digestive tract, which is why drugs from this category may not be used all patients.

Before buying antihypertensive drugs, you need to study the instructions and consult with your doctor. To achieve a positive therapeutic effect, it is necessary to strictly observe the dosage, since otherwise orthostatic hypotension may develop.

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Classification

Angiotensin 2 receptor antagonists are usually divided into several categories according to indicators of pharmacological activity, characteristics of drug interactions and structural structure. Thanks to this, you can always choose the most suitable drug that will not provoke the occurrence of adverse reactions.

In traditional medicine, there are 4 groups of sartans:

  • Biphenyl derivatives of tetrazole.
  • Non-biphenyl nettetrazole.
  • Non-cyclic compounds.
  • Non-biphenyl derivatives of tetrazole.

Angiotensin 2 receptor blockers include only those drugs that have good bioavailability, and also retain the maximum therapeutic effect for a long time time. After undergoing a therapeutic course, you can improve lipid metabolism, reduce the concentration of total cholesterol and triglycerides in the blood.

Angiotensin 2 (II) receptor antagonists. List of drugs, mechanism of action, classification
Angiotensin 2 receptor antagonists - mechanism of action

Numerous clinical studies have shown that sartans can be prescribed to patients with connective tissue pathologies. For example, with Marfan syndrome. Angiotensin 2 receptor blockers strengthen the walls of the aorta to prevent rupture. Sartans also improve the condition of muscle tissue, which is extremely important in Duchenne muscular dystrophy.

Rating of drugs from the pharmacy

Angiotensin 2 receptor antagonists are in great demand in cardiology, since the pharmacological properties these drugs can improve blood circulation in the brain, which is extremely important for the prevention of the occurrence of stroke. In patients with diagnosed diabetes mellitus, sartans reduce the likelihood of developing renal dysfunction.

Name of the medicinal product Average price in Russia (rub.)
Angiakand 310
Irsar 478
Lozap 670
Mikardis 1110
Valsacor 720
Vasotenz 253
Diovan 1730
Lorista 420
Candesartan 217
Telmisartan 230

Only a healthcare professional can prescribe effective and safe angiotensin 2 receptor blockers for blood pressure normalization and treatment hypertension, since it is necessary to take into account the age of the patient, his current condition, the form of the diagnosed disease and the presence of concomitant pathologies.

Angiakand

This drug has a diuretic, hypotensive and vasodilating principle of action. Angiakand is produced in tablet form.

It is an effective angiotensin II receptor antagonist, which contains the following substances:

  • The main component is candesartan cilexetil.
  • Excipients: E468, lactose monohydrate, pregelatinized corn starch, magnesium stearate, K30 povidone.

Angiakand is recommended for use in the presence of a syndrome of increased blood pressure, as well as in chronic heart failure, which is accompanied by systolic dysfunction of the left ventricle.Angiotensin 2 (II) receptor antagonists. List of drugs, mechanism of action, classification

The drug is contraindicated in the presence of the following diseases and conditions:

  • Severe liver pathologies.
  • Childhood.
  • Pregnancy, lactation.
  • Hypersensitivity of the body to any constituent components of the drug.
  • Hypolactasia.
  • Primary hyperaldosteronism.

An angiotensin 2 receptor inhibitor should be taken at 8 mg per day. With insufficient blood pressure control, the dosage can be increased to 16 mg. The maximum daily dose of the drug should not exceed 32 mg. The duration of the therapeutic course is determined by the attending physician of the patient.

The use of the pharmacological agent Angiakand can provoke the occurrence of the following side reactions:

  • Migraine attacks.
  • Hypercreatininemia.
  • Arthralgia.
  • Functional disorders in the work of the kidneys.
  • Neutropenia.
  • Hyponatremia.
  • Hyperkalemia.

Even a single excess of the permissible dosage of the drug Angiakand can provoke the development of tachycardia, as well as a sharp decrease in blood pressure. An antihypertensive agent is sold only by prescription.

Irsar

The drug has an antihypertensive principle of action. Irsar is produced in the form of tablets. The active ingredient is irbertan.

Additionally, the preparation includes:

  • Primellose (croscarmellose sodium).
  • Lactose monohydrate.
  • Povidone K30.
  • E460.
  • Pregelatinized starch.
  • Stearic acid.
  • Talc.

It is recommended to use the pharmacological agent Irsar for essential hypertension, as well as for nephropathy that has arisen against the background of type 2 diabetes mellitus or arterial hypertension.Angiotensin 2 (II) receptor antagonists. List of drugs, mechanism of action, classification

Contraindications:

  • Pregnancy, lactation.
  • Childhood.
  • Individual intolerance to the components of Irsar.
  • Lactose deficiency.

You need to take a medication once a day, 150 mg. In severe cases of the disease, the dosage of the angiotensin 2 receptor inhibitor should be increased to 300 mg. The duration of the therapeutic course is determined by the attending physician.

In isolated cases, the drug Irsar provokes the occurrence of the following side reactions:

  • Increased fatigue.
  • Flushing of the face.
  • Arthralgia, myalgia.
  • Hyperkalemia.
  • A pronounced decrease in blood pressure indicators.

An independent increase in the recommended dosage of the drug is fraught with the occurrence of bradycardia and tachycardia. To normalize the condition, you need to stop taking Irsar and seek advice from your doctor. You can buy the drug only if you have a prescription.

Lozap

The drug is sold in the form of tablets. The active ingredient of the drug is losartan potassium.

Excipients:

  • E468.
  • Dimethicone.
  • Povidone.
  • Talc.
  • Mannitol.
  • Stearic acid.
  • Hypromellose.
  • Microcrystalline cellulose.
  • Macrogol.
  • Yellow dye.

Lozap is intended for the treatment of arterial hypertension, diabetic nephropathy and chronic heart failure. The drug helps to reduce the likelihood of developing diseases of the cardiovascular system in those patients who suffer from left ventricular hypertrophy.

The medicinal product is prohibited to use in the following cases:

  • Individual intolerance to the components that are part of the drug.
  • Dehydration of the body.
  • Hyperkalemia.
  • Children's age (up to 18 years old).
  • The period of bearing the child, lactation.

You need to take Lozap tablets at 50 mg per day. If necessary, the daily dosage can be increased to 100 mg. The initial dose for patients with heart failure is 12.5 mg (once a day). Gradually, the dosage of the drug should be increased to 50 mg. The duration of treatment is determined on an individual basis.

Angiotensin 2 (II) receptor antagonists. List of drugs, mechanism of action, classification
Lozap

The following side reactions are indicated in the instructions for the drug:

  • Discomfort in the epigastric region.
  • Angina pectoris (a clinical syndrome that is recognized as the most common form of coronary heart disease).
  • Arrhythmia.
  • Migraine.
  • Insomnia.
  • Limb tremor.

In the case of the use of large doses of an angiotensin 2 receptor antagonist, the patient may experience bradycardia, tachycardia or hypotension. You can buy Lozap only with a prescription.

Mikardis

The drug is available in the form of white oblong tablets.

The composition of the drug includes an active component - telmisartan, as well as auxiliary substances:

  • Glucitol.
  • Stearic acid.
  • Meglumin.
  • Povidone.
  • Caustic soda.

In traditional medicine, Mikardis is prescribed to those patients who are diagnosed with hypertension or have other chronic diseases of the cardiovascular system.

In the annotation to the drug, the manufacturer indicated the following contraindications:

  • Obstructive diseases of the biliary tract.
  • Children's age (up to 18 years old).
  • Pregnancy, lactation.
  • Kidney dysfunction.
  • Diabetes.
  • Individual intolerance to the components of the drug.
  • Primary hyperaldosteronism.

For the treatment of hypertension, you need to take 40 mg of the drug 1 time per day. In the absence of a positive therapeutic effect, the dosage of the drug can be increased to 80 mg. To prevent the development of cardiovascular diseases, cardiologists prescribe Mikardis at 20-40 mg. With liver dysfunction, it is permissible to take up to 40 mg of the drug per day. The duration of the therapeutic course is determined by the attending physician on an individual basis.Angiotensin 2 (II) receptor antagonists. List of drugs, mechanism of action, classification

If, before using the drug, the patient did not take into account the existing contraindications, then in the course of treatment, the following side reactions may occur:

  • Attacks of nausea, vomiting.
  • Allergic reaction (urticaria, itching and burning of the skin, Quincke's edema).
  • Thrombocytopenia.
  • Sleep disturbance.
  • Short-term decrease in visual acuity.
  • Muscle pain.

In medical practice, no cases of overdose of the drug Mikardis have yet been recorded.

But the manufacturer of the drug does not exclude the possibility that, due to the use of a large dose of an angiotensin 2 receptor inhibitor, they may the following symptoms occur:

  • Decrease in blood pressure indicators to critical levels.
  • Vomit.
  • Increased body temperature.
  • General malaise.
  • Chills.
  • Diarrhea.
  • Limb tremor.

You can buy Mikardis only with a doctor's prescription.

Valsacor

Angiotensin 2 receptor antagonists help to reduce the intensity of myocardial hypertrophy, which is inevitable in the development of arterial hypertension. Valsacor comes in pill form. Valsartan is included in the composition of the drug as an active substance.

The following auxiliary components help to enhance the therapeutic effect of the drug:

  • Magnesium stearate.
  • Lactose monohydrate.
  • Colloidal silicon dioxide.
  • E468.
  • MCC.
  • Povidone.

Valsacor is prescribed to patients for the treatment of cardiovascular failure and left ventricular diastolic dysfunction after myocardial infarction. The drug is effective in combating arterial hypertension and class II-IV chronic heart failure.

Contraindications for use:

  • Renal artery stenosis.
  • Chronic kidney disease.
  • Childhood.
  • Hypersensitivity to the components of the drug.
  • The period of bearing the child, lactation.Angiotensin 2 (II) receptor antagonists. List of drugs, mechanism of action, classification

Valsacor should be taken 2 times a day, 20-40 mg. Gradually, the dosage of the drug can be increased to 80-160 mg. The cardiologist should determine the safe dose and regimen of the drug. Otherwise, there is a high likelihood of a deterioration in well-being. against the background of adverse reactions:

  • Rhinitis, sinusitis.
  • Arthralgia.
  • Migraine.
  • Myalgia.
  • Orthostatic hypotension.
  • Nausea, vomiting.
  • Stool disorder.
  • Asthenia.

The daily use of Valsacor in large doses can negatively affect the balance of electrolytes, which is fraught with a rapid deterioration in overall well-being. Additionally, the patient may be disturbed by: a sharp decrease in blood pressure indicators, hypovolemia, dizziness and chills. Correction of pronounced arterial hypotension is carried out by intravenous administration of sodium chloride (0.9%). You can buy an antihypertensive drug only with a doctor's prescription.

Vasotenz

The drug is available exclusively in tablet form. As an active ingredient in the composition of the drug Vasotens includes potassium losartan.

The following excipients help to enhance the therapeutic effect of the drug:

  • Croscarmellose sodium.
  • Povidone K30.
  • Mannitol.
  • Talc.
  • Magnesium stearate.
  • Propylene glycol.
  • Hypromellose 6.

The drug Vazotenz is intended for the treatment of chronic heart failure and hypertension.Angiotensin 2 (II) receptor antagonists. List of drugs, mechanism of action, classification

In the annotation to the drug, the manufacturer indicated the following contraindications:

  • Dehydration.
  • Liver failure.
  • Hypersensitivity of the body to the components of the drug.
  • Arterial hypotension.
  • Increased plasma potassium.
  • Pregnancy.
  • The period of breastfeeding the baby.
  • Childhood.

The drug should be taken once a day, regardless of food. With arterial hypertension, Vasotens is recommended to take 50 mg per day. In severe cases, the dosage should be increased to 100 mg.

In heart failure, the initial dose of the drug is 12.5 mg. It is recommended to double the daily dose on 3-4 days of treatment. The maximum daily dosage of the drug should not exceed 50 mg.

In isolated cases, the components of the described angiotensin II receptor inhibitor can provoke the following adverse reactions:

  • Bronchitis, rhinitis.
  • Hypotension.
  • Decrease in the level of hemoglobin in the blood.
  • Stool disorder.
  • Nausea, vomiting.
  • Kidney dysfunction.
  • Aching pain in muscles, joints.
  • Insomnia.

If the patient independently increases the dosage of the drug, then with a probability of 98% he will develop tachycardia, bradycardia or hypotension. To improve the patient's well-being, forced diuresis may be prescribed, or the cardiologist will recommend individual symptomatic treatment. Vazotenz is released according to the prescription of the attending physician.

Diovan

Angiotensin 2 receptor antagonists are effective in systolic dysfunction of the left ventricle, as well as in the presence of a history of a patient with diabetes mellitus with concomitant nephrotic syndrome. The drug Diovan, which is available in tablet form, has good tolerance and a minimum number of contraindications. Valsartan is the main component of a pharmacological agent.

Additionally, the composition includes the following excipients:

  • Silicon oxide (E551).
  • Microcrystalline cellulose.
  • Crospovidone.
  • Macrogol 8000.
  • Stearic acid.
  • E171.
  • E172.
  • Hypromellose.

Angiotensin 2 (II) receptor antagonists. List of drugs, mechanism of action, classificationThe pharmacological agent Diovan is effective in acute myocardial infarction and systolic dysfunction of the left ventricle, as well as in the syndrome of increased systolic blood pressure.

The drug is prohibited to use during pregnancy and breastfeeding of a child, as well as in case of hypersensitivity of the body to the components of an angiotensin 2 receptor inhibitor.

To achieve the maximum therapeutic effect, Diovan should be taken 1 time per day, 80 mg. The drug exhibits a hypotensive effect after 2 weeks of systematic drug treatment. The maximum therapeutic effect from the use of the drug can be achieved only after 30 days. A safe treatment regimen should be drawn up by the attending physician on an individual basis.

Only in 2% of cases Diovan provokes the occurrence of side reactions:

  • Dizziness.
  • Neutropenia.
  • Thrombocytopenia.
  • Limb tremor.
  • Vasculitis.
  • Myalgia.
  • Renal failure
  • Nausea, vomiting.
  • Allergic reaction.

The use of the drug Diovan in large doses can provoke a sharp decrease in blood pressure, which is why anaphylactic shock or collapse is possible. To normalize the patient's well-being, the patient needs to wash the stomach, and intravenously inject a 0.9% sodium chloride solution. The drug is sold only by prescription.

Lorista

This pharmacological agent is available in the form of film-coated tablets. The active ingredient of the drug is potassium losartan.

The auxiliary components include:

  • Corn starch.
  • Colloidal silicon dioxide.
  • Stearic acid.
  • Pregelatinized starch (starch that has been cooked).
  • Lactose monohydrate, cellulose.
  • Microcrystalline cellulose.

The drug Lorista is an effective antagonist of angiotensin 2 receptors, since it can be used to achieve significant improvement in the condition of those patients who are diagnosed with chronic heart failure or arterial hypertension. The drug can reduce the risk of stroke in the presence of left ventricular myocardial hypertrophy in the patient. Lorista helps preserve kidney function in patients with type 2 diabetes.

Contraindications for use:

  • Hypersensitivity to the components of the drug.
  • Severe liver pathologies.
  • Hypolactasia.
  • Children's age (up to 18 years old).
  • Pregnancy, lactation.
Angiotensin 2 (II) receptor antagonists. List of drugs, mechanism of action, classification
Lorista

You need to take Lorista's medicine once a day, 1 tablet (regardless of food). The drug shows the maximum therapeutic effect after 30-45 days of treatment. For hypertension, the recommended daily dose of the drug is 50 mg. The exact treatment regimen can only be drawn up by the attending physician.

Medical statistics confirm that only 1 patient out of 1000 after using the drug Lorista has the following adverse reactions:

  • Migraine.
  • Bronchitis, pharyngitis.
  • Dyspepsia.
  • A slight increase in the level of urea and creatinine in the blood.
  • Anemia.
  • Angioedema.
  • Short-term decrease in visual acuity.

An independent increase in the permissible dosage of the drug can provoke the occurrence of tachycardia and a decrease in blood pressure. In this case, the patient is shown symptomatic treatment. In addition, forced diuresis can be prescribed. The drug is sold by prescription only.

Candesartan

Antagonists help to weaken the effect of agonists by counteracting them. Angiotensin 2 receptor blockers show the maximum therapeutic effect only with systematic use. In cardiology, the drug Candesartan is in great demand, which is produced in tablet form and contains candesartan, which is used as an active substance.

The following excipients help to enhance the effect of the drug:

  • Microcrystalline cellulose.
  • Lactose monohydrate.
  • E468.
  • Povidone.
  • Starch.
  • Sodium stearyl fumarate.
  • E551.

The drug Candesartan is recommended for use in the syndrome of increased systolic blood pressure and left ventricular myocardial hypertrophy. The drug can also be used to treat diabetic nephropathy.

In the annotation to the drug Candesartan, the following contraindications are indicated:

  • Hyperkalemia.
  • Renal artery stenosis (narrowing of the diameter of one or both renal arteries or their branches).
  • Pregnancy.
  • Primary hyperaldosteronism.
  • Hypersensitivity to the components of a pharmacological agent.
  • The period of bearing a child.
  • Severe pathology of the urinary system.

An angiotensin 2 receptor antagonist - selective candesartan, which is well tolerated by patients over 18 years of age. The initial dosage of the drug is 4 mg.Angiotensin 2 (II) receptor antagonists. List of drugs, mechanism of action, classification

Candesartan tablets should be taken orally once a day (regardless of food). The maximum daily dosage is 16 mg. In the presence of kidney and liver pathologies, the daily dose of the drug should be reduced to 2 mg. When undergoing a therapeutic course, it is necessary to control the level of creatinine, urea and potassium in the blood.

In isolated cases, patients may experience the following side reactions:

  • Arthralgia.
  • Allergic reaction to the components of the drug (itching and burning of the skin, Quincke's edema).
  • Myalgia.
  • Rhinitis.
  • Dizziness.
  • Thrombocytopenia.

If the patient takes Candesartan in large doses, then his condition will rapidly deteriorate against the background of severe weakness, hypotension and frequent migraine attacks. You can buy the drug with a doctor's prescription.

Telmisartan

This pharmacological agent is available in the form of white tablets. Telmisartan is an active ingredient in the preparation.

Auxiliary components:

  • Sorbitol.
  • Magnesium stearate.
  • Sodium hydroxide.
  • Mannitol.
  • E464.
  • Meglumin.
  • Povidone.

Telmisartan is indicated for the treatment of arterial hypertension. The drug is recommended to be used to reduce the likelihood of death of the patient from cardiovascular diseases. systems after a heart attack, stroke, as well as in the presence of a history of peripheral diseases vessels. Telmisartan is effective for left ventricular myocardial hypertrophy.

The drug is prohibited to use in the presence of the following pathologies and conditions:

  • Primary aldosteronism.
  • Obstructive pathology of the biliary tract.
  • Childhood.
  • Fructosemia.
  • Hypersensitivity of the body to the components of the drug.
  • The period of bearing a child.
  • Severe liver failure.

In 99% of cases, Telmisartan is well tolerated by the body of patients over 18 years of age.Angiotensin 2 (II) receptor antagonists. List of drugs, mechanism of action, classification

Only in isolated situations do the following side reactions occur:

  • Bradycardia.
  • Dyspepsia.
  • Limb cramps.
  • Anemia.
  • Vertigo.
  • Dyspnea.
  • Discomfort in the epigastric region.

For effective treatment of arterial hypertension, Telmisartan should be taken 40 mg once a day. After you feel better, the dosage can be reduced to 20 mg. The maximum daily dose of the drug is 80 mg. A standard therapeutic course is designed for 2-3 months. To lower blood pressure, Telmisartan is prescribed simultaneously with thiazide diuretics. To prolong life in chronic cardiovascular diseases, the drug is recommended to be taken daily at a dosage of 40-80 mg.

If the patient will systematically violate the dosage and frequency of use of the angiotensin 2 receptor antagonist, then, with a 95% probability, he will have the following overdose symptoms:

  • Dizziness.
  • Severe renal failure.
  • Decrease in blood pressure indicators to critical levels.
  • Tachycardia.

In case of an overdose, you need to abandon the further use of Telmisartan, rinse the stomach and take a sorbent (for example, activated carbon). You can buy medicine only with a doctor's prescription.

Even with the regular use of angiotensin 2 receptor blockers, it is impossible to immediately achieve the desired antihypertensive effect. A steady decrease in blood pressure occurs after 14-30 days of drug therapy. Receptor antagonists accumulate in the body, due to which the maximum effect can be achieved after 6-8 weeks of treatment.

Angiotensin Receptor Antagonist Videos

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